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Protein Overview: GEM1

General Information:
Name(s) found: GEM1 / YAL048C [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 662 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: vesicle-mediated transport [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: GTPase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKETIRVVI CGDEGVGKSS LIVSLTKAEF IPTIQDVLPP ISIPRDFSSS PTYSPKNTVL  60
   61 IDTSDSDLIA LDHELKSADV IWLVYCDHES YDHVSLFWLP HFRSLGLNIP VILCKNKCDS 120
  121 ISNVNANAMV VSENSDDDID TKVEDEEFIP ILMEFKEIDT CIKTSAKTQF DLNQAFYLCQ 180
  181 RAITHPISPL FDAMVGELKP LAVMALKRIF LLSDLNQDSY LDDNEILGLQ KKCFNKSIDV 240
  241 NELNFIKDLL LDISKHDQEY INRKLYVPGK GITKDGFLVL NKIYAERGRH ETTWAILRTF 300
  301 HYTDSLCIND KILHPRLVVP DTSSVELSPK GYRFLVDIFL KFDIDNDGGL NNQELHRLFK 360
  361 CTPGLPKLWT STNFPFSTVV NNKGCITLQG WLAQWSMTTF LNYSTTTAYL VYFGFQEDAR 420
  421 LALQVTKPRK MRRRSGKLYR SNINDRKVFN CFVIGKPCCG KSSLLEAFLG RSFSEEYSPT 480
  481 IKPRIAVNSL ELKGGKQYYL ILQELGEQEY AILENKDKLK ECDVICLTYD SSDPESFSYL 540
  541 VSLLDKFTHL QDLPLVFVAS KADLDKQQQR CQIQPDELAD ELFVNHPLHI SSRWLSSLNE 600
  601 LFIKITEAAL DPGKNTPGLP EETAAKDVDY RQTALIFGST VGFVALCSFT LMKLFKSSKF 660
  661 SK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) GEM1 HUA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3829 - low filter Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..197] PSI-BLAST 106.522879 Rac
    2 View Details [198..289] ORFEUS 10.03 Troponin C
    3 View Details [290..430] ORFEUS 10.03 Troponin C
    4 View Details [431..662] PSI-BLAST 82.9897 CDC42

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  3.64858540496165 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.89122312915795 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.81593838944939 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.79724985811732 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.79347973548337 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity
    		•  2.44176688200537 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.38215814751368 bayes_pls_golite062009
  • motor activity
    		•  2.1532118704195 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • hydrolase activity
    		•  1.40217504818333 bayes_pls_golite062009
  • GTPase activity
    		•  1.23010905798386 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • signal transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • protein transporter activity
    		•  1.05248757342537 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.990320704369021 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.777787753097919 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.568484017802328 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • receptor activity
    		•  0.381142123108547 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.355770151889237 bayes_pls_golite062009
  • tubulin binding
    		•  0.326239364039846 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  0.226790072388501 bayes_pls_golite062009
  • microtubule binding
    		•  0.225323885896927 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.0775601177068852 bayes_pls_golite062009
  • actin binding
    		•  0.0206144204131673 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  3.05873877511752 bayes_pls_golite062009
  • microfilament motor activity
    		•  1.9984373493184 bayes_pls_golite062009
  • metal ion binding
    		•  1.78612329591962 bayes_pls_golite062009
  • cation binding
    		•  1.78612329591962 bayes_pls_golite062009
  • ion binding
    		•  1.7794276789734 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.57685201816793 bayes_pls_golite062009
  • signal transducer activity
    		•  1.57685201816793 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.52831937678894 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  1.26291497318874 bayes_pls_golite062009
  • motor activity
    		•  1.22884221769274 bayes_pls_golite062009
  • transporter activity
    		•  1.18173318787461 bayes_pls_golite062009
  • protein binding
    		•  1.09433047543741 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.967232199555998 bayes_pls_golite062009
  • calcium ion binding
    		•  0.96333115642547 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.898362179169385 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.713088884599039 bayes_pls_golite062009
  • actin binding
    		•  0.571065725792783 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.471661454726807 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.467743512816825 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.255162242356474 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.224800334961602 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.206190076128058 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.137921428032586 bayes_pls_golite062009
  • DNA binding
    		•  0.126696463568471 bayes_pls_golite062009
  • tubulin binding
    		•  0.121694931665203 bayes_pls_golite062009
  • gated channel activity
    		•  0.0726874243760007 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0385263849284123 bayes_pls_golite062009
    3
    Term Confidence Notes
  • microtubule motor activity
    		•  3.64858540496165 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.89122312915795 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.81593838944939 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.79724985811732 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.79347973548337 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity
    		•  2.44176688200537 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.38215814751368 bayes_pls_golite062009
  • motor activity
    		•  2.1532118704195 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • hydrolase activity
    		•  1.40217504818333 bayes_pls_golite062009
  • GTPase activity
    		•  1.23010905798386 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • signal transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • protein transporter activity
    		•  1.05248757342537 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.990320704369021 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.777787753097919 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.568484017802328 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • receptor activity
    		•  0.381142123108547 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.355770151889237 bayes_pls_golite062009
  • tubulin binding
    		•  0.326239364039846 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  0.226790072388501 bayes_pls_golite062009
  • microtubule binding
    		•  0.225323885896927 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.0775601177068852 bayes_pls_golite062009
  • actin binding
    		•  0.0206144204131673 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle