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Protein Overview: tup12

General Information:
Name(s) found: tup12 / SPAC630.14c [Sanger Pombe]
Description(s) found:
Found 16 descriptions.
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  • transcriptional corepressor Tup12 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 586 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    nuclear chromatin [ICLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    protein complex [RCALink to PubMed article]
    Biological Process: chromatin remodeling in response to cation stress [IEPLink to PubMed article][IMPLink to PubMed article]
    negative regulation of transcription by glucose [IMPLink to PubMed article]
    chromatin silencing [IMPLink to PubMed article]
    response to cation stress [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    histone binding [IDALink to PubMed article]
    transcription corepressor activity [IDALink to PubMed article][IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITVRQFTFT IFKFQFMATS NVSSRVNELL EAVKKEFEDI CQKTKTVEAQ KDDFEYKAMI  60
   61 SAQINEMALM KQTVMDLEMQ QSKVKDRYEE EITSLKAQLE ARRKEIASGV VPQSSKTKHG 120
  121 RNSVSFGKYG NAGPFNSDNS SKPLILNNGS SGGTPKNLRS PAIDSDGTVL APIQTSNVDL 180
  181 GSQYYSSPHV RPAVGATMAG SAMRTFPSNL PLGHPPPPSD SANSSVTPIA APLVVNGKVS 240
  241 GNPPYPAEII PTSNVPNREE KDWTVTSNVP NKEPPISVQL LHTLEHTSVI CYVRFSADGK 300
  301 FLATGCNRAA MVFNVETGKL ITLLQEESSK REGDLYVRSV AFSPDGKYLA TGVEDQQIRI 360
  361 WDIAQKRVYR LLTGHEQEIY SLDFSKDGKT LVSGSGDRTV CLWDVEAGEQ KLILHTDDGV 420
  421 TTVMFSPDGQ FIAAGSLDKV IRIWTSSGTL VEQLHGHEES VYSVAFSPDG KYLVSGSLDN 480
  481 TIKLWELQCV SNVAPSMYKE GGICKQTFTG HKDFILSVTV SPDGKWIISG SKDRTIQFWS 540
  541 PDSPHSQLTL QGHNNSVISV AVSPNGHCFA TGSGDLRARI WSYEDL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..126] FFAS03 1.25 Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
    2 View Details [127..212] deduced N/A No confident structure predictions are available.
    3 View Details [213..275] PSI-BLAST 7.0 TolB, C-terminal domain; TolB, N-terminal domain
    4 View Details [276..586] PSI-BLAST 60.39794 Tup1, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
    		• 6.67009948605948 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K4 specific)
    		•  4.71992275913384 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  4.33124151198369 bayes_pls_golite062009
  • GTPase activity
    		•  4.02994814377904 bayes_pls_golite062009
  • actin binding
    		•  3.86142918698875 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.85374902981345 bayes_pls_golite062009
  • RNA binding
    		•  3.77273677738815 bayes_pls_golite062009
  • myosin II binding
    		•  3.56132510021228 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.35098520158193 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.31615347567536 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.25521258308263 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.14917998298348 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.99343906593123 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • structural molecule activity
    		•  2.6914565031145 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • snoRNA binding
    		•  2.27164613239345 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  2.10926890165617 bayes_pls_golite062009
  • dynactin binding
    		•  2.07556426531897 bayes_pls_golite062009
  • actin filament binding
    		•  2.0735069176589 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.85632145559025 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • receptor activity
    		•  1.69781740346574 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.5281054405163 bayes_pls_golite062009
  • kinase activity
    		•  1.5053563627859 bayes_pls_golite062009
  • telomerase activity
    		•  1.44665328127499 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.42581655945599 bayes_pls_golite062009
  • signal transducer activity
    		•  1.42581655945599 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.35170368882651 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.33036729957356 bayes_pls_golite062009
  • protein kinase activity
    		•  1.3214585007945 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • RNA-directed DNA polymerase activity
    		•  1.10560669001943 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • mRNA binding
    		•  1.05053985350578 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • myosin binding
    		•  0.989691178611801 bayes_pls_golite062009
  • protein transporter activity
    		•  0.964340340346761 bayes_pls_golite062009
  • type 1 angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • transferase activity
    		•  0.913674310517261 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  0.656824577987243 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.625780732991652 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.618638900707402 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.443846546939402 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.43316396073854 bayes_pls_golite062009
  • peptide binding
    		•  0.387345823168967 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.28606552120995 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.220747580531792 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.161639372576406 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • receptor binding
    		•  0.0390635451962911 bayes_pls_golite062009
  • kinase binding
    		•  0.0366162235750993 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00858004043229577 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.00335766408304172 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle