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Protein Overview: ago1

General Information:
Name(s) found: ago1 / SPCC736.11 [Sanger Pombe]
Description(s) found:
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  • pir||T41568 argonaute-like protein - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|3169081|emb|CAA19275.1| argonaute [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19075282|ref|NP_587782.1| argonaute [Schizosaccharomyces pombe] [NCBI NR]
  • gi|11386877|sp|O74957.1|AGO1_SCHPO RecName: Full=Protein argonaute; AltName: Full=Eukaryotic translation initiation factor 2C 2-like protein ago1; AltName: Full=Protein slicer; AltName: Full=PAZ Piwi domain protein ago1; AltName: Full=Cell cycle control p [NCBI NR]
  • argonaute [Sanger Pombe]
  • Protein argonaute OS=Schizosaccharomyces pombe GN=ago1 PE=1 SV=1 [Swiss-Prot]
  • TRANSLATION INITIATION FACTOR EIF2C; ARGONAUTE; PIWI AND ZAP DOMAINS; NO APPARENT S. CEREVISIAE ORTHOLOG: O74957; [pompepVF.fasta]
  • TRANSLATION INITIATION FACTOR EIF2C; ARGONAUTE; PIWI AND ZAP DOMAINS: O74957; [pompepV13]
  • Probable eukaryotic translation initiation factor 2C (eIF2C) (eIF-2C) [pompep4896]
  • |ago1|csp9|argonaute [pompepnew.fasta]
  • Cell cycle control protein ago1 (RNA interference pathway protein ago1) [4896.FASTAC]
  • |ago1|csp9|argonaute|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • putative argonuate-like protein [Schizosaccharomyces pombe]gi|3169081|emb|CAA19275.1| SPCC736.11 [Schizosaccharomyces pombe]gi|7490119|pir||T41568 argonaute-like protein - fission yeast (Schizosaccharomyces pombe)gi|11386877|sp|O74957|AGO1_SCHPO Cell c [nrdb_11152004_Chlamydomonas]
  • (O74957) Probable eukaryotic translation initiation factor 2C (eIF2C) (eIF-2C) [pompep4896_normal_reversed]
  • hypothetical protein SPCC736.11 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPCC736.11 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Protein argonaute OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ago1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 834 amino acids

    Gene Ontology:
    Cellular Component: mating-type region heterochromatin [IDALink to PubMed article]
    nuclear telomeric heterochromatin [IDALink to PubMed article]
    RITS complex [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    ARC complex [IDALink to PubMed article]
    centromeric heterochromatin [IDALink to PubMed article]
    Biological Process: chromatin silencing at centromere [IMPLink to PubMed article]
    regulation of histone H3-K9 methylation [IMPLink to PubMed article]
    chromosome segregation [IGILink to PubMed article]
    regulation of chromatin silencing at centromere [IMPLink to PubMed article]
    conversion of ds siRNA to ss siRNA involved in RNA interference [IMPLink to PubMed article]
    [NOT]chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    RNA interference [TASLink to PubMed article]
    [NOT]chromatin silencing at telomere [IMPLink to PubMed article]
    chromatin silencing by small RNA [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYKPSSEIA LRPGYGGLGK QITLKANFFQ IISLPNETIN QYHVIVGDGS RVPRKQSQLI  60
   61 WNSKEVKQYF GSSWMNSVYD GRSMCWSKGD IADGTIKVNI GSESHPREIE FSIQKSSKIN 120
  121 LHTLSQFVNS KYSSDPQVLS SIMFLDLLLK KKPSETLFGF MHSFFTGENG VSLGGGVEAW 180
  181 KGFYQSIRPN QGFMSVNVDI SSSAFWRNDS LLQILMEYTD CSNVRDLTRF DLKRLSRKFR 240
  241 FLKVTCQHRN NVGTDLANRV YSIEGFSSKS ASDSFFVRRL NGEEQKISVA EYFLENHNVR 300
  301 LQYPNLPCIL VKNGAMLPIE FCFVVKGQRY TAKLNSDQTA NMIRFAVQRP FERVQQIDDF 360
  361 VHQMDWDTDP YLTQYGMKIQ KKMLEVPARV LETPSIRYGG DCIERPVSGR WNLRGKRFLD 420
  421 PPRAPIRSWA VMCFTSTRRL PMRGIENFLQ TYVQTLTSLG INFVMKKPPV LYADIRGSVE 480
  481 ELCITLYKKA EQVGNAPPDY LFFILDKNSP EPYGSIKRVC NTMLGVPSQC AISKHILQSK 540
  541 PQYCANLGMK INVKVGGINC SLIPKSNPLG NVPTLILGGD VYHPGVGATG VSIASIVASV 600
  601 DLNGCKYTAV SRSQPRHQEV IEGMKDIVVY LLQGFRAMTK QQPQRIIYFR DGTSEGQFLS 660
  661 VINDELSQIK EACHSLSPKY NPKILVCTTQ KRHHARFFIK NKSDGDRNGN PLPGTIIEKH 720
  721 VTHPYQYDFY LISHPSLQGV SVPVHYTVLH DEIQMPPDQF QTLCYNLCYV YARATSAVSL 780
  781 VPPVYYAHLV SNLARYQDVT ADDTFVETSE ASMDQEVKPL LALSSKLKTK MWYM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..834] PSI-BLAST 55.39794 Crystal structure of A. aeolicus Argonaute

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • miRNA binding
    		•  8.69268950569308 bayes_pls_golite062009
  • RNA cap binding
    		•  6.0791415062122 bayes_pls_golite062009
  • translation initiation factor activity
    		•  5.50078893654345 bayes_pls_golite062009
  • RNA 7-methylguanosine cap binding
    		•  5.43471478554516 bayes_pls_golite062009
  • ribonuclease activity
    		•  5.30591758406946 bayes_pls_golite062009
  • siRNA binding
    		•  4.26412929341885 bayes_pls_golite062009
  • ribonuclease III activity
    		•  4.20335726467076 bayes_pls_golite062009
    		• 4.10363762148891 bayes_pls_golite062009
  • exoribonuclease activity
    		•  3.71639182685131 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  3.59362615133405 bayes_pls_golite062009
  • exonuclease activity
    		•  3.13676176369406 bayes_pls_golite062009
  • nuclease activity
    		•  3.11657409772275 bayes_pls_golite062009
  • RNA binding
    		•  3.01997241125209 bayes_pls_golite062009
  • transposase activity
    		•  2.97988408226992 bayes_pls_golite062009
  • ribonuclease H activity
    		•  2.91966688044755 bayes_pls_golite062009
  • hydrolase activity
    		•  2.78602644579272 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.70794511869438 bayes_pls_golite062009
  • endonuclease activity
    		•  2.63074055051349 bayes_pls_golite062009
  • endoribonuclease activity
    		•  2.59247838057313 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.20855917457806 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.14285769817394 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  2.12039058720352 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.94077739152313 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.87431870698721 bayes_pls_golite062009
  • DNA binding
    		•  1.86594005896134 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.74431545836806 bayes_pls_golite062009
  • DNA polymerase activity
    		•  1.64519652804477 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.59628511603826 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  1.54576601235316 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  1.44123900197846 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.363399194272 bayes_pls_golite062009
  • binding
    		•  1.35497934205068 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • translation regulator activity
    		•  1.24691427875148 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.22763794139559 bayes_pls_golite062009
  • transcription activator activity
    		•  1.1830013572628 bayes_pls_golite062009
  • transcription factor activity
    		•  1.17659544650821 bayes_pls_golite062009
  • mRNA binding
    		•  1.10473275263716 bayes_pls_golite062009
  • protein binding
    		•  1.08578027658199 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.782108781904855 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.77421125364834 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.599626528449085 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58055486321736 bayes_pls_golite062009
  • kinase activity
    		•  0.557302038379807 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • protein kinase activity
    		•  0.354993329967566 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.283883977748512 bayes_pls_golite062009
  • double-stranded RNA-specific ribonuclease activity
    		•  0.222737597484808 bayes_pls_golite062009
  • transferase activity
    		•  0.0868471791986259 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0701825322473915 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle