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The process by which small interfering RNAs target cognate mRNA molecules for degradation. The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference. A process of negative regulation of translation that is mediated by the association of small interfering RNAs (siRNAs) with a cognate target mRNA. Cleavage of double-stranded RNA to form lsiRNA (long small interfering RNA), a class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions. Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation. Any process by which RNA molecules inactivate expression of target genes. The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference. The inactivation of gene expression by a posttranscriptional mechanism.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: RNA interference
Acc: GO:0016246
Aspect: Biological Process
Desc: The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
Synonyms:
  • posttranscriptional gene silencing by siRNA
  • RNAi
Proteins in PDR annotated with:
   This term: 115 [Search]
   Term or descendants: 154 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016246 - RNA interference (interactive image map)
YRC Informatics Platform - Version 3.0
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