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Protein Overview: sws-PA

General Information:
Name(s) found: sws-PA / FBpp0071077 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene swiss cheese is referred to in FlyBase by the symbol Dmel\sws (CG2212, FBgn0003656). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:7850853..7862269. It has the cytological map location 7D1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: lysophospholipase activity. There is experimental evidence that it is involved in the biological process</span>: membrane lipid metabolic process; phosphatidylcholine metabolic process; membrane organization; neuron apoptosis. 16 alleles are reported. The phenotypes of these alleles are annotated with: epithelial glial cell; CNS glial cell; lamina cortex; neuropil compartment; eye photoreceptor cell; adult brain. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1425 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IEA]
    Biological Process: phosphatidylcholine metabolic process [IDA]
    cellular membrane organization [IDA]
    brain development [NAS]
    neuron apoptosis [IMP]
    membrane lipid metabolic process [IDA]
    Molecular Function: lysophospholipase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATVYMYFA LVMMSLLFIA WFLYFKRMAR  60
   61 LRLRDEIARS ISTVTNSSGD MRGLRFRKRD KMLFYGRRML RKMKNVSGQM YSSGKGYKRR 120
  121 AVMRFARRIL QLRRDNMPLE MRTVEPPAEY LEETIEGSDR VPPDALYMLQ SIRIFGHFEK 180
  181 PVFLRLCKHT QLLELMAGDY LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE 240
  241 SVTSLLSFID VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI 300
  301 RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQAPN GPPMVISQMN 360
  361 LMQSAVSGTG SSGVSVTVTR PPSSPSRHSR EEHTLSDPNP NPDGSFHGTT NLFTEVHGDA 420
  421 PNADLFHQQQ QQHSVGNLST RRSSITLMAP DGSHSCLQTP GVTTSIDMRL VQSSAVDSLR 480
  481 KELGLSEEDS HIIEPFVELR ELEPNVTLIT EGNADDVCVW FVMTGTLAVY QSNQDATRAK 540
  541 QDKSDMLIHF VHPGEIVGGL AMLTGEASAY TIRSRSITRI AFIRRAAIYQ IMRQRPRIVL 600
  601 DLGNGVVRRL SPLVRQCDYA LDWIFLESGR AVYRQDESSD STYIVLSGRM RSVITHPGGK 660
  661 KEIVGEYGKG DLVGIVEMIT ETSRTTTVMA VRDSELAKLP EGLFNAIKLR YPIVVTKLIS 720
  721 FLSHRFLGSM QTRSGSGAPG APVEANPVTH KYSTVALVPI TDEVPMTPFT YELYHSLCAI 780
  781 GPVLRLTSDV VRKQLGSNIF EAANEYRLTS WLAQQEDRNI ITLYQCDSSL SAWTQRCMRQ 840
  841 ADVILIVGLG DRSHLVGKFE REIDRLAMRT QKELVLLYPE ASNAKPANTL SWLNARPWVT 900
  901 KHHHVLCVKR IFTRKSQYRI NDLYSRVLLS EPNMHSDFSR LARWLTGNSI GLVLGGGGAR 960
  961 GAAHIGMLKA IQEAGIPVDM VGGVSIGALM GALWCSERNI TTVTQKAREW SKKMTKWFLQ1020
 1021 LLDLTYPITS MFSGREFNKT IHDTFGDVSI EDLWIPYFTL TTDITASCHR IHTNGSLWRY1080
 1081 VRSSMSLSGY MPPLCDPKDG HLLLDGGYVN NLPADVMHNL GAAHIIAIDV GSQDDTDLTN1140
 1141 YGDDLSGWWL LYKKWNPFTS PVKVPDLPDI QSRLAYVSCV RQLEEVKNSD YCEYIRPPID1200
 1201 KYKTLAFGSF DEIRDVGYVF GKNYFESMAK AGRLGRFNQW FNKEPPKRVN HASLNEYTFI1260
 1261 DLAQIVCRLP ETYAVNTAEL FSEDEDCDGY ISEPTTLNTD RRRIQVSRAG NSLSFSETEM1320
 1321 DSDVELDLKL ERKTDKSTQS SPPSNSRSDM RGKEEARHMS NWHWGVKHKD ETGSGATEAT1380
 1381 KTQTGQEQEL QQEQQDQGAT AEQLVDKDKE ENKENRSSPN NETKN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..159] deduced N/A No confident structure predictions are available.
    2 View Details [160..565] PSI-BLAST 30.39794 Regulatory domain of epac2, domain 2; Regulatory domain of Epac2, domains 1 and 3
    3 View Details [566..801] PSI-BLAST 41.69897 Regulatory subunit of Protein kinase A
    4 View Details [802..946] deduced N/A No confident structure predictions are available.
    5 View Details [947..1246] PSI-BLAST 19.30103 Patatin
    6 View Details [1247..1425] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.65363761161862 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.26124379267933 bayes_pls_golite062009
  • ion channel activity
    		•  0.848870337502738 bayes_pls_golite062009
  • protein binding
    		•  0.83595203347671 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.795033986592028 bayes_pls_golite062009
  • channel activity
    		•  0.789135243365643 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.789135243365643 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.711500871939896 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.711500871939896 bayes_pls_golite062009
  • gated channel activity
    		•  0.69445530625204 bayes_pls_golite062009
  • cation channel activity
    		•  0.574425804123918 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.26551164934064 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.250292406962674 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  1.65363761161862 bayes_pls_golite062009
  • ion channel activity
    		•  0.848870337502738 bayes_pls_golite062009
  • protein binding
    		•  0.83595203347671 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.795033986592028 bayes_pls_golite062009
  • channel activity
    		•  0.789135243365643 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.789135243365643 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.711500871939896 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.711500871939896 bayes_pls_golite062009
  • gated channel activity
    		•  0.69445530625204 bayes_pls_golite062009
  • cation channel activity
    		•  0.574425804123918 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.250292406962674 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • phospholipase activity
    		•  3.87963112297417 bayes_pls_golite062009
  • phospholipase A2 activity
    		•  3.8689576466535 bayes_pls_golite062009
  • lipase activity
    		•  1.83391969295473 bayes_pls_golite062009
  • catalytic activity
    		•  1.681309422157 bayes_pls_golite062009
  • binding
    		•  1.32516854558392 bayes_pls_golite062009
  • hydrolase activity
    		•  1.23737416083983 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  1.20394174397151 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  1.07865077162953 bayes_pls_golite062009
  • [acyl-carrier-protein] S-malonyltransferase activity
    		•  0.812816692540436 bayes_pls_golite062009
  • S-malonyltransferase activity
    		•  0.812816692540436 bayes_pls_golite062009
  • malonyltransferase activity
    		•  0.812816692540436 bayes_pls_golite062009
  • calcium-independent phospholipase A2 activity
    		•  0.5938636898178 bayes_pls_golite062009
  • carboxylesterase activity
    		•  0.431665185524913 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.39017969987234 bayes_pls_golite062009
  • acyltransferase activity
    		•  0.350701756346828 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  0.295883900540457 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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