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Protein Overview: Dl-PB, Dl-PA, FB...

General Information:
Name(s) found: FBpp0293200 [FlyBase]
Dl-PB / FBpp0083154 [FlyBase]
Dl-PA / FBpp0083153 [FlyBase]
Description(s) found:
Found 48 descriptions.
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  • type=protein; loc=3R:complement(15130550..15132311,15134429..15134483,15137538..15137786,15141728..15141794,15145540..15145851,15151204..15151260); ID=FBpp0293200; name=Dl-PC; parent=FBgn0000463,FBtr0304658; dbxref=REFSEQ:NP_001247193,GB_protein:AFH06511,FlyBase:FBpp0293200,FlyBase_Annotation_IDs:CG3619-PC; MD5=b3e984d4c399e9db113b0227208cf84a; length=833; release=r5.56; species=Dmel; [FlyBase]
  • The gene Delta is referred to in FlyBase by the symbol Dmel\Dl (CG3619, FBgn0000463). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15128453..15151935. It has the cytological map location 92A1-92A2. There is experimental evidence that it has the molecular function</span>: Notch binding; sequence-specific DNA binding. There is experimental evidence for 23 unique biological process</span> terms, many of which group under: anatomical structure development; reproductive process in a multicellular organism; organ morphogenesis; organ development; leg morphogenesis; multicellular organism reproduction; ovarian follicle cell development; stem cell differentiation; regulation of developmental process; sensory organ development; cellular component movement; regulation of biological process. 444 alleles are reported. The phenotypes of these alleles are annotated with 104 unique terms, many of which group under: adult segment; peripheral nervous system; external compound sense organ; organ system; nervous system; adult mesothoracic segment; embryonic nervous system; embryonic neuron; female germline cyst; primordium. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Delta is referred to in FlyBase by the symbol Dmel\Dl (CG3619, FBgn0000463). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15128453..15151935. It has the cytological map location 92A1-92A2. There is experimental evidence that it has the molecular function</span>: Notch binding; sequence-specific DNA binding. There is experimental evidence for 23 unique biological process</span> terms, many of which group under: anatomical structure development; reproductive process in a multicellular organism; organ morphogenesis; organ development; leg morphogenesis; multicellular organism reproduction; ovarian follicle cell development; stem cell differentiation; regulation of developmental process; sensory organ development; cellular component movement; regulation of biological process. 444 alleles are reported. The phenotypes of these alleles are annotated with 104 unique terms, many of which group under: adult segment; peripheral nervous system; external compound sense organ; organ system; nervous system; adult mesothoracic segment; embryonic nervous system; embryonic neuron; female germline cyst; primordium. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 833 amino acids

    Gene Ontology:
    Cellular Component: endocytic vesicle [IDA]
    adherens junction [IDA]
    subapical complex [IDA]
    integral to membrane [IEA][NAS][TAS]
    cytoplasmic vesicle [IDA]
    plasma membrane [IDA]
    Biological Process: leg segmentation [IMP]
    dorsal/ventral lineage restriction, imaginal disc [TAS]
    mesoderm development [IMP]
    nervous system development [NAS]
    imaginal disc-derived wing morphogenesis [IMP]
    regulation of R8 cell spacing in compound eye [NAS]
    actin filament organization [IMP]
    cell adhesion [TAS]
    R8 cell differentiation [NAS]
    imaginal disc-derived wing vein specification [NAS]
    imaginal disc-derived wing vein morphogenesis [TAS]
    border follicle cell migration [IMP]
    ectoderm development [NAS][TAS]
    apposition of dorsal and ventral imaginal disc-derived wing surfaces [IMP]
    compound eye cone cell fate commitment [TAS]
    oocyte anterior/posterior axis specification [TAS]
    glial cell migration [IMP]
    stem cell differentiation [IMP]
    ovarian follicle cell development [IMP][TAS]
    cell fate specification [TAS]
    oocyte localization during germarium-derived egg chamber formation [IMP]
    leg joint morphogenesis [IMP]
    negative regulation of terminal cell fate specification, open tracheal system [NAS]
    imaginal disc-derived leg morphogenesis [IMP]
    negative regulation of fusion cell fate specification [NAS]
    ommatidial rotation [NAS]
    R8 cell fate commitment [TAS]
    peripheral nervous system development [IMP][TAS]
    antennal morphogenesis [IMP]
    compound eye retinal cell programmed cell death [TAS]
    establishment of ommatidial planar polarity [TAS]
    asymmetric cell division [TAS]
    R3/R4 cell fate commitment [NAS]
    compound eye development [TAS]
    sensory organ development [IMP]
    open tracheal system development [NAS]
    ventral cord development [NAS]
    bristle morphogenesis [IMP]
    Notch signaling pathway [IGI][IMP][NAS][TAS]
    central nervous system development [NAS]
    ovarian follicle cell stalk formation [IMP]
    oogenesis [IMP][TAS]
    germ-line stem cell maintenance [IMP]
    lateral inhibition [IMP][NAS][TAS]
    establishment of planar polarity [NAS]
    wing disc dorsal/ventral pattern formation [IMP]
    negative regulation of neurogenesis [IMP]
    Molecular Function: calcium ion binding [IEA]
    Notch binding [IDA][NAS][TAS]
    signal transducer activity [TAS]
    receptor binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHWIKCLLTA FICFTVIVQV HSSGSFELRL KYFSNDHGRD NEGRCCSGES DGATGKCLGS  60
   61 CKTRFRVCLK HYQATIDTTS QCTYGDVITP ILGENSVNLT DAQRFQNKGF TNPIQFPFSF 120
  121 SWPGTFSLIV EAWHDTNNSG NARTNKLLIQ RLLVQQVLEV SSEWKTNKSE SQYTSLEYDF 180
  181 RVTCDLNYYG SGCAKFCRPR DDSFGHSTCS ETGEIICLTG WQGDYCHIPK CAKGCEHGHC 240
  241 DKPNQCVCQL GWKGALCNEC VLEPNCIHGT CNKPWTCICN EGWGGLYCNQ DLNYCTNHRP 300
  301 CKNGGTCFNT GEGLYTCKCA PGYSGDDCEN EIYSCDADVN PCQNGGTCID EPHTKTGYKC 360
  361 HCANGWSGKM CEEKVLTCSD KPCHQGICRN VRPGLGSKGQ GYQCECPIGY SGPNCDLQLD 420
  421 NCSPNPCING GSCQPSGKCI CPAGFSGTRC ETNIDDCLGH QCENGGTCID MVNQYRCQCV 480
  481 PGFHGTHCSS KVDLCLIRPC ANGGTCLNLN NDYQCTCRAG FTGKDCSVDI DECSSGPCHN 540
  541 GGTCMNRVNS FECVCANGFR GKQCDEESYD SVTFDAHQYG ATTQARADGL TNAQVVLIAV 600
  601 FSVAMPLVAV IAACVVFCMK RKRKRAQEKD DAEARKQNEQ NAVATMHHNG SGVGVALASA 660
  661 SLGGKTGSNS GLTFDGGNPN IIKNTWDKSV NNICASAAAA AAAAAAADEC LMYGGYVASV 720
  721 ADNNNANSDF CVAPLQRAKS QKQLNTDPTL MHRGSPAGSS AKGASGGGPG AAEGKRISVL 780
  781 GEGSYCSQRW PSLAAAGVAG ACSSQLMAAA SVAGSGAGTA QQQRSVVCGT PHM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..234] FFAS03 2.13 No description for 2dduA was found.
    2 View Details [235..338] PSI-BLAST 8.69897 No description for 2gy5A was found.
    3 View Details [339..508] PSI-BLAST 5.0 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    4 View Details [509..561] PSI-BLAST 16.0 NMR structure of the human NOTCH-1 ligand binding region
    5 View Details [562..657] deduced N/A No confident structure predictions are available.
    6 View Details [658..727] deduced N/A No confident structure predictions are available.
    7 View Details [728..833] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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