Protein Overview: gi|24647463, gi|...

General Information:
Name(s) found:	gi\|27923743 [NCBI NR] gi\|24647463 [NCBI NR] gi\|23171477 [NCBI NR]
Description(s) found: Found 12 descriptions. SHOW ALL	gi\|27923743\|sp\|Q9VEU1.2\|CAD89_DROME RecName: Full=Cadherin-89D; Flags: Precursor [NCBI NR] gi\|24647463\|ref\|NP_650554.2\| Cad89D [Drosophila melanogaster] [NCBI NR] gi\|23171477\|gb\|AAF55327.2\| Cad89D [Drosophila melanogaster] [NCBI NR]
Organism:	Drosophila melanogaster
Length:	2240 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [ISS] integral to membrane [NAS] plasma membrane [IEA]
Biological Process:	calcium-dependent cell-cell adhesion [ISS][NAS] cell adhesion [ISS] homophilic cell adhesion [IEA]
Molecular Function:	calcium ion binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSEAYPMKS SVKISQKKKA SQDMAVICVW VMPLAVFGLI AIGQAAKTGQ VQGNSGSCAF  60
   61 HTLDGVAAES EGVRFIRLRE DAQVGKEILR LQAYPRSTAA LKGADASGDH KYFNLTEHNA 120
  121 TTLVVSLARS LERLVDRDVP RNLLKFRILC AGKQEKLEEG SYLSITVYIE DVNDNAPEFL 180
  181 NVPYVVDVDE NTSIESIIFE GVQAFDRDKP NTPNSEVHFS MSTVPEQLSA DGSPYFALKS 240
  241 PHRPLLILKR ELDFDNGIRQ FKLPIFAWDR GTPANQANTT ITINVRDVDD LPPKFTEGVY 300
  301 RTRINEFYPM TGVPIRIPLY FAPPIMAFDQ DSLNASLVYD IISGNERQLF RVNPHNGVMY 360
  361 LQKEIDLEEE SLPGNTFVLQ LEARQKDNPL KKALARIEVE VLDLNDNVPE FEADYYNISI 420
  421 VENLPTGFSV LQVNAVDRDQ GENSEFLYNL VETKDAAGAF RIDSRTGWIT VRDDRLLDRE 480
  481 QRRSIQLNVE ALERNPSYLD DKHLKKPGPS KVQVEITLLD TNDNTPKFEH GNLYEFKVPI 540
  541 NAPTGYVIGQ VVAHDPDEGP NGHLLYELQR PKGSGYIPFR LDNKNGTIYV GGPLRRGRIA 600
  601 VFVEATDQPT NPSERRFSLA VITIEVYATI DDQAIDFVGA PYEFWVGANT PLGTSVGQVR 660
  661 TTLIYEGGDE IMYDLLHTYS EGVPFAIEER SGIITVIREL SEFKRKVYQF EAVANYLFAN 720
  721 SSQSLVMSRS SSPLTTIASP AELSDEGVLI TNLTIHIVNK PEQKVPLRPV IEEINMNVIH 780
  781 FHVEENVVGG IIGQLLYKNG INLVNNELGT YREMPSEPTS RNITMGSRFR SRNRSRSSKS 840
  841 KRRLPRRLVG DANIKLRYII ANQQEVVNKI SITEDGTLLT LTGLDREQQP SYELTVIVEY 900
  901 STGLVSGAGI YQVNIKVDDV NDNAPKFNAL TYVGLINENC VVGTELSMNH AILIQDADEG 960
  961 PNAEFRVQLQ GDYSDEFSIE YVNGTSSENS THHKMPSTTG AFNIFNLTDQ WNDEFKYQEL1020
 1021 HTTFMQTNFK LSSGPYFRIS YTGKRGLDRE KQQLYNLKII AADTGGLSGY AHLTVLVADV1080
 1081 NDNAPMFERI SVFKDSRLEI REYTTDMEIY FVESSSGMTA PQATAAMMLA PPPYHIPGSP1140
 1141 RFNVDRERSV GAGLGVVARA KSRRRMVRAL TTKCPLFAIY EDTPVGTKVL QLSASDEDFG1200
 1201 KNALLHYELQ GEQVERTPGM PMLRVHGVKY FAIDKLSGEL SVNYPLSANI EIMLNLTVTD1260
 1261 IDGLKDSTCL RFTVMDVNNH APTFKKSWYS FDTPEGEYKD SVLGQLTAID MDFGENANIT1320
 1321 YTLSDSHLPF TIKPASGVLK IGGQLDRELK DKYSFQVIAT DNAPVMQRMS SSVDVEVNVL1380
 1381 DINDNRPEFI GYDDQTKAVK FIPSVADRTL MLPVYKAYLD RSTQPGTFVR QLTAIDKDNV1440
 1441 GNGNGLVLYS IRHQEMQAPL FQIDSRDGTI STISRINGYN DYEHLNVSVI ASDVGSPALS1500
 1501 ATAIVIVNLQ GQAVTDPPKS TPKPEPPANV TVFQHAYYEV KLTENNEAPI EVMRLNLSAG1560
 1561 LNPENYRWSL WLEEGLDETD AHPPFEYDAK NMLLYALKPF DREHISRYQL RIRADRLSRE1620
 1621 ARNYARVSYP VVDERIEGLS LNECRILVHI ADENDNAPKF RGNGQPIVAV LPQSASFGYP1680
 1681 VTRVEANDLD EGLNAEIRYR LLNEPARLFG IDELSGNIRL LGELSRTEHI YGFDVKATDR1740
 1741 MGADDGRSGI VNVFVYIINE AKQVRLVVAG MPVEVERRIE GLMEALSDAI GKDVRVRLLE1800
 1801 PYSGGLEPAT NAYIYAVDPH TNSIMEMEQL QDALAGLQLD ALQLQQQKLD GGKPMPRILE1860
 1861 LAEFGQLARP AHASASSFMG GLEFVTVVLL ALISLGALIA ACCYVCMRQK RRLWSQRDFS1920
 1921 ASDAGLTYTI AGIGSPRGQK QRRQRQQRHT QRCSKGSTGS QRPTSAFMPE SVCSSAQTQS1980
 1981 TATATEKLEQ QLHHHHQQQA MATQQQHHQY LNEQQRQQKR EYIDVPLPKS IAKAAAVTSG2040
 2041 GDGAVGVGST PFVLKYNACQ PVNNLNNYET SLFSLHSTGQ DSGVEFLSSR ELYETSPDSF2100
 2101 QHGGSKRGNN TEVLCPRHAK AHLELRQPNT DSSDTYEDSL KTDEPLVAHN CRSANCEHRQ2160
 2161 HQQHPSHHPH YQNTRFEKRS CVRHSFSGVK DDLMQQSPQI SLRPRGHALR NSMNDLEQRL2220
 2221 HNLEQSFRRP LEFSKSNSLF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..174]	PSI-BLAST	24.69897	Structure of EC1 domain of CNR
2	View Details	[175..759]	FFAS03	10.6	C-cadherin ectodomain
3	View Details	[760..835]	deduced	N/A	No confident structure predictions are available.
4	View Details	[836..959]	FFAS03	3.22	No description for 1zxkA was found.
5	View Details	[960..1084]	PSI-BLAST	11.522879	STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
6	View Details	[1085..1174]	deduced	N/A	No confident structure predictions are available.
7	View Details	[1175..1295]	PSI-BLAST	37.69897	E-cadherin (epithelial)
8	View Details	[1296..1876]	PSI-BLAST	75.69897	W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography
9	View Details	[1877..1981]	deduced	N/A	No confident structure predictions are available.
10	View Details	[1982..2079]	MSA	2.049974	View MSA. No confident structure predictions are available.
11	View Details	[2080..2240]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
cell adhesion molecule binding	3.19367562970896	bayes_pls_golite062009
receptor activity	2.5256294718594	bayes_pls_golite062009
transmembrane receptor activity	2.10923172564176	bayes_pls_golite062009
binding	1.89176357327828	bayes_pls_golite062009
molecular transducer activity	1.86767346187817	bayes_pls_golite062009
signal transducer activity	1.86767346187817	bayes_pls_golite062009
G-protein coupled receptor activity	1.69585074100447	bayes_pls_golite062009
RPTP-like protein binding	1.68541653552341	bayes_pls_golite062009
beta-catenin binding	1.60656892011613	bayes_pls_golite062009
protein binding	1.2486671660298	bayes_pls_golite062009
transcription regulator activity	1.24409711891756	bayes_pls_golite062009
transporter activity	0.863724831300677	bayes_pls_golite062009
transmembrane transporter activity	0.688682339597643	bayes_pls_golite062009
proton-dependent oligopeptide secondary active transmembrane transporter activity	0.528528464646393	bayes_pls_golite062009
secondary active oligopeptide transmembrane transporter activity	0.528528464646393	bayes_pls_golite062009
substrate-specific transporter activity	0.491786688714933	bayes_pls_golite062009
receptor binding	0.283569691623987	bayes_pls_golite062009

3

No functions predicted.

4

No functions predicted.

5

Term	Confidence	Notes
cell adhesion molecule binding	3.53124748663376	bayes_pls_golite062009
receptor activity	2.60335849566679	bayes_pls_golite062009
RPTP-like protein binding	2.16914804650901	bayes_pls_golite062009
transmembrane receptor activity	2.14462434886014	bayes_pls_golite062009
binding	1.95002373838391	bayes_pls_golite062009
molecular transducer activity	1.89064998704554	bayes_pls_golite062009
signal transducer activity	1.89064998704554	bayes_pls_golite062009
beta-catenin binding	1.8656144140373	bayes_pls_golite062009
G-protein coupled receptor activity	1.79832011407406	bayes_pls_golite062009
protein binding	1.33394526471138	bayes_pls_golite062009
transcription regulator activity	1.23055638745499	bayes_pls_golite062009
proton-dependent oligopeptide secondary active transmembrane transporter activity	0.958774971306261	bayes_pls_golite062009
secondary active oligopeptide transmembrane transporter activity	0.958774971306261	bayes_pls_golite062009
transporter activity	0.851228093937992	bayes_pls_golite062009
transmembrane transporter activity	0.677581850277121	bayes_pls_golite062009
substrate-specific transporter activity	0.483421965826537	bayes_pls_golite062009
receptor binding	0.29427207676736	bayes_pls_golite062009

6

No functions predicted.

7

Term	Confidence	Notes
cell adhesion molecule binding	3.53124748663376	bayes_pls_golite062009
receptor activity	2.60335849566679	bayes_pls_golite062009
RPTP-like protein binding	2.16914804650901	bayes_pls_golite062009
transmembrane receptor activity	2.14462434886014	bayes_pls_golite062009
binding	1.95002373838391	bayes_pls_golite062009
molecular transducer activity	1.89064998704554	bayes_pls_golite062009
signal transducer activity	1.89064998704554	bayes_pls_golite062009
beta-catenin binding	1.8656144140373	bayes_pls_golite062009
G-protein coupled receptor activity	1.79832011407406	bayes_pls_golite062009
protein binding	1.33394526471138	bayes_pls_golite062009
transcription regulator activity	1.23055638745499	bayes_pls_golite062009
proton-dependent oligopeptide secondary active transmembrane transporter activity	0.958774971306261	bayes_pls_golite062009
secondary active oligopeptide transmembrane transporter activity	0.958774971306261	bayes_pls_golite062009
transporter activity	0.851228093937992	bayes_pls_golite062009
transmembrane transporter activity	0.677581850277121	bayes_pls_golite062009
substrate-specific transporter activity	0.483421965826537	bayes_pls_golite062009
receptor binding	0.29427207676736	bayes_pls_golite062009

8

No functions predicted.

9

No functions predicted.

10

No functions predicted.

11

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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