| Protein: | gi|24647463, gi|... |
| Organism: | Drosophila melanogaster |
| Length: | 2240 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24647463, gi|....
| Description | E-value | Query Range |
Subject Range |
|
|
1754.0 | [0..13] | [2240..13] |
|
Region A: Residues: [1-174] |
1 11 21 31 41 51
| | | | | |
1 MDSEAYPMKS SVKISQKKKA SQDMAVICVW VMPLAVFGLI AIGQAAKTGQ VQGNSGSCAF 60
61 HTLDGVAAES EGVRFIRLRE DAQVGKEILR LQAYPRSTAA LKGADASGDH KYFNLTEHNA 120
121 TTLVVSLARS LERLVDRDVP RNLLKFRILC AGKQEKLEEG SYLSITVYIE DVND
|
| Detection Method: |  |
| Confidence: | 24.69897 |
| Match: | 1wuzA |
| Description: | Structure of EC1 domain of CNR |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [175-759] |
1 11 21 31 41 51
| | | | | |
1 NAPEFLNVPY VVDVDENTSI ESIIFEGVQA FDRDKPNTPN SEVHFSMSTV PEQLSADGSP 60
61 YFALKSPHRP LLILKRELDF DNGIRQFKLP IFAWDRGTPA NQANTTITIN VRDVDDLPPK 120
121 FTEGVYRTRI NEFYPMTGVP IRIPLYFAPP IMAFDQDSLN ASLVYDIISG NERQLFRVNP 180
181 HNGVMYLQKE IDLEEESLPG NTFVLQLEAR QKDNPLKKAL ARIEVEVLDL NDNVPEFEAD 240
241 YYNISIVENL PTGFSVLQVN AVDRDQGENS EFLYNLVETK DAAGAFRIDS RTGWITVRDD 300
301 RLLDREQRRS IQLNVEALER NPSYLDDKHL KKPGPSKVQV EITLLDTNDN TPKFEHGNLY 360
361 EFKVPINAPT GYVIGQVVAH DPDEGPNGHL LYELQRPKGS GYIPFRLDNK NGTIYVGGPL 420
421 RRGRIAVFVE ATDQPTNPSE RRFSLAVITI EVYATIDDQA IDFVGAPYEF WVGANTPLGT 480
481 SVGQVRTTLI YEGGDEIMYD LLHTYSEGVP FAIEERSGII TVIRELSEFK RKVYQFEAVA 540
541 NYLFANSSQS LVMSRSSSPL TTIASPAELS DEGVLITNLT IHIVN
|
| Detection Method: | |
| Confidence: | 10.6 |
| Match: | 1l3wA |
| Description: | C-cadherin ectodomain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| cell adhesion molecule binding | 3.19367562970896 | bayes_pls_golite062009 |
| receptor activity | 2.5256294718594 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.10923172564176 | bayes_pls_golite062009 |
| binding | 1.89176357327828 | bayes_pls_golite062009 |
| molecular transducer activity | 1.86767346187817 | bayes_pls_golite062009 |
| signal transducer activity | 1.86767346187817 | bayes_pls_golite062009 |
| G-protein coupled receptor activity | 1.69585074100447 | bayes_pls_golite062009 |
| RPTP-like protein binding | 1.68541653552341 | bayes_pls_golite062009 |
| beta-catenin binding | 1.60656892011613 | bayes_pls_golite062009 |
| protein binding | 1.2486671660298 | bayes_pls_golite062009 |
| transcription regulator activity | 1.24409711891756 | bayes_pls_golite062009 |
| transporter activity | 0.863724831300677 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.688682339597643 | bayes_pls_golite062009 |
| proton-dependent oligopeptide secondary active transmembrane transporter activity | 0.528528464646393 | bayes_pls_golite062009 |
| secondary active oligopeptide transmembrane transporter activity | 0.528528464646393 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.491786688714933 | bayes_pls_golite062009 |
| receptor binding | 0.283569691623987 | bayes_pls_golite062009 |
|
Region A: Residues: [760-835] |
1 11 21 31 41 51
| | | | | |
1 KPEQKVPLRP VIEEINMNVI HFHVEENVVG GIIGQLLYKN GINLVNNELG TYREMPSEPT 60
61 SRNITMGSRF RSRNRS
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [836-959] |
1 11 21 31 41 51
| | | | | |
1 RSSKSKRRLP RRLVGDANIK LRYIIANQQE VVNKISITED GTLLTLTGLD REQQPSYELT 60
61 VIVEYSTGLV SGAGIYQVNI KVDDVNDNAP KFNALTYVGL INENCVVGTE LSMNHAILIQ 120
121 DADE
|
| Detection Method: | |
| Confidence: | 3.22 |
| Match: | 1zxkA |
| Description: | No description for 1zxkA was found. |
|
Region A: Residues: [960-1084] |
1 11 21 31 41 51
| | | | | |
1 GPNAEFRVQL QGDYSDEFSI EYVNGTSSEN STHHKMPSTT GAFNIFNLTD QWNDEFKYQE 60
61 LHTTFMQTNF KLSSGPYFRI SYTGKRGLDR EKQQLYNLKI IAADTGGLSG YAHLTVLVAD 120
121 VNDNA
|
| Detection Method: | |
| Confidence: | 11.522879 |
| Match: | 1ncgA |
| Description: | STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| cell adhesion molecule binding | 3.53124748663376 | bayes_pls_golite062009 |
| receptor activity | 2.60335849566679 | bayes_pls_golite062009 |
| RPTP-like protein binding | 2.16914804650901 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.14462434886014 | bayes_pls_golite062009 |
| binding | 1.95002373838391 | bayes_pls_golite062009 |
| molecular transducer activity | 1.89064998704554 | bayes_pls_golite062009 |
| signal transducer activity | 1.89064998704554 | bayes_pls_golite062009 |
| beta-catenin binding | 1.8656144140373 | bayes_pls_golite062009 |
| G-protein coupled receptor activity | 1.79832011407406 | bayes_pls_golite062009 |
| protein binding | 1.33394526471138 | bayes_pls_golite062009 |
| transcription regulator activity | 1.23055638745499 | bayes_pls_golite062009 |
| proton-dependent oligopeptide secondary active transmembrane transporter activity | 0.958774971306261 | bayes_pls_golite062009 |
| secondary active oligopeptide transmembrane transporter activity | 0.958774971306261 | bayes_pls_golite062009 |
| transporter activity | 0.851228093937992 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.677581850277121 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.483421965826537 | bayes_pls_golite062009 |
| receptor binding | 0.29427207676736 | bayes_pls_golite062009 |
|
Region A: Residues: [1085-1174] |
1 11 21 31 41 51
| | | | | |
1 PMFERISVFK DSRLEIREYT TDMEIYFVES SSGMTAPQAT AAMMLAPPPY HIPGSPRFNV 60
61 DRERSVGAGL GVVARAKSRR RMVRALTTKC
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1175-1295] |
1 11 21 31 41 51
| | | | | |
1 PLFAIYEDTP VGTKVLQLSA SDEDFGKNAL LHYELQGEQV ERTPGMPMLR VHGVKYFAID 60
61 KLSGELSVNY PLSANIEIML NLTVTDIDGL KDSTCLRFTV MDVNNHAPTF KKSWYSFDTP 120
121 E
|
| Detection Method: | |
| Confidence: | 37.69897 |
| Match: | 1edhA |
| Description: | E-cadherin (epithelial) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| cell adhesion molecule binding | 3.53124748663376 | bayes_pls_golite062009 |
| receptor activity | 2.60335849566679 | bayes_pls_golite062009 |
| RPTP-like protein binding | 2.16914804650901 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.14462434886014 | bayes_pls_golite062009 |
| binding | 1.95002373838391 | bayes_pls_golite062009 |
| molecular transducer activity | 1.89064998704554 | bayes_pls_golite062009 |
| signal transducer activity | 1.89064998704554 | bayes_pls_golite062009 |
| beta-catenin binding | 1.8656144140373 | bayes_pls_golite062009 |
| G-protein coupled receptor activity | 1.79832011407406 | bayes_pls_golite062009 |
| protein binding | 1.33394526471138 | bayes_pls_golite062009 |
| transcription regulator activity | 1.23055638745499 | bayes_pls_golite062009 |
| proton-dependent oligopeptide secondary active transmembrane transporter activity | 0.958774971306261 | bayes_pls_golite062009 |
| secondary active oligopeptide transmembrane transporter activity | 0.958774971306261 | bayes_pls_golite062009 |
| transporter activity | 0.851228093937992 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.677581850277121 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.483421965826537 | bayes_pls_golite062009 |
| receptor binding | 0.29427207676736 | bayes_pls_golite062009 |
|
Region A: Residues: [1296-1876] |
1 11 21 31 41 51
| | | | | |
1 GEYKDSVLGQ LTAIDMDFGE NANITYTLSD SHLPFTIKPA SGVLKIGGQL DRELKDKYSF 60
61 QVIATDNAPV MQRMSSSVDV EVNVLDINDN RPEFIGYDDQ TKAVKFIPSV ADRTLMLPVY 120
121 KAYLDRSTQP GTFVRQLTAI DKDNVGNGNG LVLYSIRHQE MQAPLFQIDS RDGTISTISR 180
181 INGYNDYEHL NVSVIASDVG SPALSATAIV IVNLQGQAVT DPPKSTPKPE PPANVTVFQH 240
241 AYYEVKLTEN NEAPIEVMRL NLSAGLNPEN YRWSLWLEEG LDETDAHPPF EYDAKNMLLY 300
301 ALKPFDREHI SRYQLRIRAD RLSREARNYA RVSYPVVDER IEGLSLNECR ILVHIADEND 360
361 NAPKFRGNGQ PIVAVLPQSA SFGYPVTRVE ANDLDEGLNA EIRYRLLNEP ARLFGIDELS 420
421 GNIRLLGELS RTEHIYGFDV KATDRMGADD GRSGIVNVFV YIINEAKQVR LVVAGMPVEV 480
481 ERRIEGLMEA LSDAIGKDVR VRLLEPYSGG LEPATNAYIY AVDPHTNSIM EMEQLQDALA 540
541 GLQLDALQLQ QQKLDGGKPM PRILELAEFG QLARPAHASA S
|
| Detection Method: | |
| Confidence: | 75.69897 |
| Match: | 1q55A |
| Description: | W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1877-1981] |
1 11 21 31 41 51
| | | | | |
1 SFMGGLEFVT VVLLALISLG ALIAACCYVC MRQKRRLWSQ RDFSASDAGL TYTIAGIGSP 60
61 RGQKQRRQRQ QRHTQRCSKG STGSQRPTSA FMPESVCSSA QTQST
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1982-2079] |
1 11 21 31 41 51
| | | | | |
1 ATATEKLEQQ LHHHHQQQAM ATQQQHHQYL NEQQRQQKRE YIDVPLPKSI AKAAAVTSGG 60
61 DGAVGVGSTP FVLKYNACQP VNNLNNYETS LFSLHSTG
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [2080-2240] |
1 11 21 31 41 51
| | | | | |
1 QDSGVEFLSS RELYETSPDS FQHGGSKRGN NTEVLCPRHA KAHLELRQPN TDSSDTYEDS 60
61 LKTDEPLVAH NCRSANCEHR QHQQHPSHHP HYQNTRFEKR SCVRHSFSGV KDDLMQQSPQ 120
121 ISLRPRGHAL RNSMNDLEQR LHNLEQSFRR PLEFSKSNSL F
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
