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Protein Overview: Ir84a-PA

General Information:
Name(s) found: Ir84a-PA / FBpp0081058 [FlyBase]
Description(s) found:
Found 13 descriptions.
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  • The gene Ionotropic receptor 84a is referred to in FlyBase by the symbol Dmel\Ir84a (CG10101, FBgn0037501). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:3232504..3235106. It has the cytological map location 84D6. Based on sequence similarity, it is predicted to have molecular function</span>: ionotropic glutamate receptor activity; glutamate binding; extracellular-glutamate-gated ion channel activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: ionotropic glutamate receptor signaling pathway. 3 alleles are reported. The phenotype of these alleles is annotated with: sensillum coeloconica of antennal segment 3. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 693 amino acids

    Gene Ontology:
    Cellular Component: ionotropic glutamate receptor complex [ISS]
    Biological Process: ionotropic glutamate receptor signaling pathway [ISS]
    Molecular Function: glutamate binding [ISS]
    ionotropic glutamate receptor activity [ISS]
    extracellular-glutamate-gated ion channel activity [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTYKNARGP AQSKHKSPKN ESVLKWPYKM IKLQVKVISW PLIILTAFLR VLQIESINTN  60
   61 FLELAAFEDF LRSEHLSHVL VVRGDDADGD WKIECHQKLL ANYRVQFYRP EMSANFEDLM 120
  121 FYGSPRTAVL VLNSEHVLVR RQVFGVASEA GYFNNSLAWF ILGSGRESLP VEQLIDQLLS 180
  181 GYRMGIDADI TVALRGPDNA SMLFYDVYRI SRQANTPLII EKKGLWTHSG GYQKFGNFKN 240
  241 TWVIRRRNFL NVTLIGSTVV GCLPNTSPRS LTTYLQIPQL TEKPPGFGDM EYLADDKQLQ 300
  301 QLDPMQRKTY QLFQLVERMF NLSLAISLTD KWGELLDNGS WSGVMGQVTS READFAVCPI 360
  361 RFVLDRQPYV QYSAVLHTQN IHFLFRHPRR SHIKNIFFEP LSNQVWWCVL ALVTGSTILL 420
  421 LFHVRLERML SNMENRFSFV WFTMLETYLQ QGPANEIFRL FSTRLLISLS CIFSFMLMQF 480
  481 YGAFIVGSLL SESARSIVNL QALYDSNLAI GMENISYNFP IFTNTSNQLV RDVYVKKICK 540
  541 SGEHNIMSLQ QGAERIIQGR FAFHTAIDRM YRLLLELQMD EAEFCDLQEV MFNLPYDSGS 600
  601 VMPKGSPWRE HLAHALLHFR ATGLLQYNDK KWMVRRPDCS LFKTSQAEVD LEHFAPALFA 660
  661 LALAMVASAL VFLLELFLHW LPDFRRRLGT MST

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] MSA 1.197995 View MSA. No confident structure predictions are available.
    2 View Details [133..252] PSI-BLAST 4.69897 No description for 2e4zA was found.
    3 View Details [253..514] PSI-BLAST 16.69897 N-methyl-D-aspartate receptor subunit 1
    4 View Details [515..693] PSI-BLAST 28.522879 Structure of the Kainate Receptor Subunit GluR6 Agonist Binding Domain Complexed with Domoic Acid

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • amine binding
    		•  2.25634377868866 bayes_pls_golite062009
  • binding
    		•  1.99193554770277 bayes_pls_golite062009
  • receptor activity
    		•  1.74349172783363 bayes_pls_golite062009
  • signal transducer activity
    		•  1.44487216360172 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.44487216360172 bayes_pls_golite062009
  • peptide binding
    		•  1.01178416544223 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.650797312673016 bayes_pls_golite062009
  • transporter activity
    		•  0.592106222356256 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.566902324147088 bayes_pls_golite062009
  • transcription factor activity
    		•  0.392543807732656 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.385015934033076 bayes_pls_golite062009
  • DNA binding
    		•  0.366854341510606 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0690147885410379 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.0523977889638052 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0130164106420343 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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