Protein Overview: Dp-PA

General Information:
Name(s) found:	Dp-PA / FBpp0086853 [FlyBase]
Description(s) found: Found 24 descriptions. SHOW ALL	The gene DP transcription factor is referred to in FlyBase by the symbol Dmel\Dp (CG4654, FBgn0011763). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9109902..9115714. It has the cytological map location 49F10-49F11. There is experimental evidence that it has the molecular function</span>: protein binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene expression; positive regulation of nurse cell apoptosis; oogenesis; dorsal/ventral axis specification, ovarian follicular epithelium; regulation of cell cycle; cell cycle. 31 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; peripheral nervous system; external compound sense organ; nervous system; female germline cyst; adult segment; compound cell cluster organ; cell part; nucleus; egg; cell cycle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	445 amino acids
Gene Ontology:
Cellular Component:	nucleus [NAS] Rb-E2F complex [IDA] Myb complex [IDA]
Biological Process:	eggshell chorion gene amplification [TAS] oogenesis [IMP] positive regulation of gene expression [IMP] endomitotic cell cycle [TAS] regulation of transcription, DNA-dependent [IEA] dorsal/ventral axis specification, ovarian follicular epithelium [IMP] positive regulation of nurse cell apoptosis [IMP] nurse cell apoptosis [TAS] regulation of cell cycle [IMP][NAS] cell cycle [IMP] regulation of transcription from RNA polymerase II promoter [NAS]
Molecular Function:	DNA binding [IDA] transcription factor activity [IEA] protein binding [IPI] RNA polymerase II transcription factor activity [NAS] specific RNA polymerase II transcription factor activity [NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAHSTGGTVK TDEVNFFFRN EHGQISKMLK PAQNKSEMEG GKPVAVVYAT GSSARNSGSA  60
   61 SGIGNVGRMG AFSQMGSQGQ FIRLQDNGLS IPKTEAGTTY TTVSAQKTSG AGSGHYDLPL 120
  121 KGDRYVKFTP NPIKMKSKLH AIQSNSLHSM SASSSSVQRK RKPDKAGKGL RHFSMKVCEK 180
  181 VEEKGKTTYN EVADDLVSEE MKNNAYDNNC DQKNIRRRVY DALNVLMAIN VISKDKKEIR 240
  241 WIGLPANSTE TFLALEEENC QRRERIKQKN EMLREMIMQH VAFKGLVERN KRNESQGVVP 300
  301 SPNASIQLPF IIVNTHKSTK INCSVTNDKS EYIFKFDKTF EMHDDIEVLK RMGFLLGLDK 360
  361 GECTPENIER VKSWVPPNLA KYVEAYGTGK TGENMYESDD EDNEFNGYLE SANESQGFAQ 420
  421 HSAQHTTDGE FKLEMDDDEL DDDID

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
transcription regulator activity	5.55329976718261	bayes_pls_golite062009
DNA binding	5.08959163553491	bayes_pls_golite062009
nucleic acid binding	4.99681957904233	bayes_pls_golite062009
transcription factor activity	4.33152142980289	bayes_pls_golite062009
transcription activator activity	3.66421521631643	bayes_pls_golite062009
sequence-specific DNA binding	3.54603684370312	bayes_pls_golite062009
binding	3.52874320222492	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.60738445921725	bayes_pls_golite062009
transcription repressor activity	2.22485867684613	bayes_pls_golite062009
protein binding	1.80415286835431	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.2723726467408	bayes_pls_golite062009
structure-specific DNA binding	0.913018999939773	bayes_pls_golite062009
transcription factor binding	0.85714789329232	bayes_pls_golite062009
DNA-dependent ATPase activity	0.697234220778482	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.66743181561551	bayes_pls_golite062009
DNA helicase activity	0.300899564141452	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	0.23177057841536	bayes_pls_golite062009
structural molecule activity	0.111941063082739	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..60]	MSA	1.037977	View MSA. No confident structure predictions are available.
2	View Details	[61..141]	MSA	2.118993	View MSA. No confident structure predictions are available.
3	View Details	[142..243]	PSI-BLAST	30.30103	Cell cycle transcription factor DP-2
4	View Details	[244..445]	PSI-BLAST	54.0	Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer

Protein Overview: Dp-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: