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View Structure Prediction Details

Protein: Dp-PA
Organism: Drosophila melanogaster
Length: 445 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dp-PA.

Description E-value Query
Range
Subject
Range
Dp-PB - The gene DP transcription factor is referred to in FlyBase by the symbol Dmel\Dp (CG4654, FBgn001176...
496.0 [0..20] [435..16]

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Predicted Domain #1
Region A:
Residues: [1-60]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAHSTGGTVK TDEVNFFFRN EHGQISKMLK PAQNKSEMEG GKPVAVVYAT GSSARNSGSA  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [61-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGIGNVGRMG AFSQMGSQGQ FIRLQDNGLS IPKTEAGTTY TTVSAQKTSG AGSGHYDLPL  60
   61 KGDRYVKFTP NPIKMKSKLH A

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [142-243]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQSNSLHSMS ASSSSVQRKR KPDKAGKGLR HFSMKVCEKV EEKGKTTYNE VADDLVSEEM  60
   61 KNNAYDNNCD QKNIRRRVYD ALNVLMAINV ISKDKKEIRW IG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.30103
Match: 1cf7B
Description: Cell cycle transcription factor DP-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription activator activity 3.66421521631643 bayes_pls_golite062009
sequence-specific DNA binding 3.54603684370312 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
transcription repressor activity 2.22485867684613 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.2723726467408 bayes_pls_golite062009
structure-specific DNA binding 0.913018999939773 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
DNA-dependent ATPase activity 0.697234220778482 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
DNA helicase activity 0.300899564141452 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009
structural molecule activity 0.111941063082739 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [244-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPANSTETFL ALEEENCQRR ERIKQKNEML REMIMQHVAF KGLVERNKRN ESQGVVPSPN  60
   61 ASIQLPFIIV NTHKSTKINC SVTNDKSEYI FKFDKTFEMH DDIEVLKRMG FLLGLDKGEC 120
  121 TPENIERVKS WVPPNLAKYV EAYGTGKTGE NMYESDDEDN EFNGYLESAN ESQGFAQHSA 180
  181 QHTTDGEFKL EMDDDELDDD ID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.0
Match: 2azeA
Description: Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle