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Protein Overview: CG12129-PA

General Information:
Name(s) found: CG12129-PA / FBpp0087483 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG12129 (CG12129, FBgn0033475). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5920799..5922203. It has the cytological map location 46D7. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: RNA binding; catalytic activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: regulation of transcription; RNA metabolic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 352 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: RNA metabolic process [IEA]
    regulation of transcription [IEA]
    Molecular Function: RNA binding [IEA]
    catalytic activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSREVLSPPV QKMSQNRRYR VNVVHDDFGG DKWNGQNQRN KLEYKAYEEP DLYGDDDDDE  60
   61 DDAVVKCIKE SANGDFSLSI HVSKSFYGGL IGMKGSTKRR IEEETRTEIF VPRPNDRSNE 120
  121 VTIKAKQRSQ VCAALRQIHH LVASLRKKMK PTHFLAVALN SGEVKERFME LKKCILEAEL 180
  181 PGIDKELFTP ECCIHLTLGV YVLLDDIERQ EALKNLESCR RLLDGLKIPF QIKVKGLEIM 240
  241 NDDPSSTRIL YARIESPDLQ KFADQCLAHF QTTALCATDN IERESIKLHM TVMNNRYRNK 300
  301 ANKSGNSFDA REILKRFGDF DFGVAQCQAV HLCVLNSRSE DEFYKISGSL EF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..226] PSI-BLAST 19.522879 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    2 View Details [227..352] PSI-BLAST 21.154902 Crystal Structure of a Pyrococcus horikoshii protein with similarities to 2'5' RNA-ligase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.34763707358864 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.24838127771592 bayes_pls_golite062009
  • DNA binding
    		•  2.02012288821639 bayes_pls_golite062009
  • binding
    		•  1.9759530321894 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.62566906146573 bayes_pls_golite062009
  • transcription termination factor activity
    		•  1.37964248399809 bayes_pls_golite062009
  • structural molecule activity
    		•  1.30244482268813 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • transcription factor activity
    		•  1.14242112812892 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.85691075793641 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.62994126331969 bayes_pls_golite062009
  • protein binding
    		•  0.523813050066193 bayes_pls_golite062009
  • translation regulator activity
    		•  0.515576958825022 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.468402630523277 bayes_pls_golite062009
  • RNA binding
    		•  0.24714225183821 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.2080607201312 bayes_pls_golite062009
  • catalytic activity
    		•  0.10089766806364 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0761113004281331 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle