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Protein Overview: Pka-R2-PB, Pka-R2-PA

General Information:
Name(s) found: Pka-R2-PB / FBpp0087524 [FlyBase]
Pka-R2-PA / FBpp0087523 [FlyBase]
Description(s) found:
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  • gi|9295510|gb|AAF86976.1|AF274008_1 cAMP-dependent protein kinase type II regulatory subunit [Drosophila melanogaster] [NCBI NR]
  • gi|52000667|sp|P81900.2|KAPR2_DROME RecName: Full=cAMP-dependent protein kinase type II regulatory subunit [NCBI NR]
  • gi|28573932|ref|NP_788297.1| cAMP-dependent protein kinase R2, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|28573930|ref|NP_724860.2| cAMP-dependent protein kinase R2, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|28380996|gb|AAO41465.1| cAMP-dependent protein kinase R2, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|28380995|gb|AAM71046.3| cAMP-dependent protein kinase R2, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|17862674|gb|AAL39814.1| LD44591p [Drosophila melanogaster] [NCBI NR]
  • gi|17647815|ref|NP_523671.1| cAMP-dependent protein kinase R2, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|10727675|gb|AAF58862.2| cAMP-dependent protein kinase R2, isoform A [Drosophila melanogaster] [NCBI NR]
  • cAMP-dependent protein kinase type II regulatory subunit OS=Drosophila melanogaster GN=Pka-R2 PE=1 SV=2 [Swiss-Prot]
  • (P81900) cAMP-dependent protein kinase type II regulatory subunit [Swiss-Prot]
  • The gene cAMP-dependent protein kinase R2 is referred to in FlyBase by the symbol Dmel\Pka-R2 (CG15862, FBgn0022382). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5883325..5913540. It has the cytological map location 46D1-46D4. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; circadian rhythm; locomotor rhythm; behavioral response to ethanol; behavioral response to cocaine. 19 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; female germline cyst; adult segment; nervous system; peripheral nervous system; embryonic nervous system; multi-cell-component structure; thoracic segment; adult mesothoracic segment; abdominal segmental nerve; external compound sense organ. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
  • >CG15862-PC translation from_gene[CG15862 Pka-R2 FBgn0022382] seq_release:3 mol_weight=42749 cds_boundaries:(2R:5,057,127..5,066,003[-]) aa_length:377 transcript_info:[CG15862-RC seq_release:3] gene_info:[gene symbol:Pka-R2 FBgn0022382 gene_boundaries: [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG15862-PB translation from_gene[CG15862 Pka-R2 FBgn0022382] seq_release:3 mol_weight=42749 cds_boundaries:(2R:5,057,127..5,066,003[-]) aa_length:377 transcript_info:[CG15862-RB seq_release:3] gene_info:[gene symbol:Pka-R2 FBgn0022382 gene_boundaries: [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG15862-PA translation from_gene[CG15862 Pka-R2 FBgn0022382] seq_release:3 mol_weight=42749 cds_boundaries:(2R:5,057,127..5,066,003[-]) aa_length:377 transcript_info:[CG15862-RA seq_release:3] gene_info:[gene symbol:Pka-R2 FBgn0022382 gene_boundaries: [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9NB18) cAMP-dependent protein kinase type II regulatory subunit (Pka-R2 protein) (LD44591p) [DrosMelano7227.FASTAC.txt]
  • (AE003831) Pka-R2 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG15862-PC, isoform C [Drosophila melanogaster]gi|28380995|gb|AAM71046.3| CG15862-PB, isoform B [Drosophila melanogaster]gi|10727675|gb|AAF58862.2| CG15862-PA, isoform A [Drosophila melanogaster]gi|17862674|gb|AAL39814.1| LD44591p [Drosophila melanogas [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(5883996..5884126,5885209..5885394,5885776..5885851,5885920..5886067,5886212..5886307,5886930..5887030,5887239..5887420,5892662..5892875); ID=FBpp0087523; name=Pka-R2-PA; parent=FBgn0022382,FBtr0088437; dbxref=FlyBase:FBpp00 [fly-100309-contam.fasta]
  • type=protein; loc=2R:complement(5883996..5884126,5885209..5885394,5885776..5885851,5885920..5886067,5886212..5886307,5886930..5887030,5887239..5887420,5892662..5892875); ID=FBpp0087524; name=Pka-R2-PB; parent=FBgn0022382,FBtr0088438; dbxref=FlyBase:FBpp00 [fly-100309-contam.fasta]
  • type=protein; loc=2R:complement(5883996..5884126,5885209..5885394,5885776..5885851,5885920..5886067,5886212..5886307,5886930..5887030,5887239..5887420,5892662..5892875); ID=FBpp0087525; name=Pka-R2-PC; parent=FBgn0022382,FBtr0088439; dbxref=FlyBase:FBpp00 [fly-100309-contam.fasta]
  • cAMP-dependent protein kinase R2 CG15862-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG15862-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG15862-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • cAMP-dependent protein kinase type II regulatory subunit [Drosophila melanogaster] [nr-271106-contam.fasta]
  • cAMP-dependent protein kinase type II regulatory subunit [nr-271106-contam.fasta]
  • LD44591p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • cAMP-dependent protein kinase R2 CG15862-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG15862-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • cAMP-dependent protein kinase R2 CG15862-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(5883996..5884126,5885209..5885394,5885776..5885851,5885920..5886067,5886212..5886307,5886930..5887030,5887239..5887420,5892662..5892875); ID=FBpp0087523; name=Pka-R2-PA; parent=FBgn0022382,FBtr0088437; dbxref=FlyBase:FBpp0087523,FlyBase_Annotation_IDs:CG15862-PA,GB_protein:AAF58862.2,REFSEQ:NP_523671,GB_protein:AAF58862; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(5883996..5884126,5885209..5885394,5885776..5885851,5885920..5886067,5886212..5886307,5886930..5887030,5887239..5887420,5892662..5892875); ID=FBpp0087524; name=Pka-R2-PB; parent=FBgn0022382,FBtr0088438; dbxref=FlyBase:FBpp0087524,FlyBase_Annotation_IDs:CG15862-PB,GB_protein:AAM71046.3,REFSEQ:NP_724860,GB_protein:AAM71046; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(5883996..5884126,5885209..5885394,5885776..5885851,5885920..5886067,5886212..5886307,5886930..5887030,5887239..5887420,5892662..5892875); ID=FBpp0087525; name=Pka-R2-PC; parent=FBgn0022382,FBtr0088439; dbxref=FlyBase:FBpp0087525,FlyBase_Annotation_IDs:CG15862-PC,GB_protein:AAO41465.1,REFSEQ:NP_788297,GB_protein:AAO41465; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(5883996..5884126,5885209..5885394,5885776..5885851,5885920..5886067,5886212..5886307,5886930..5887030,5887239..5887420,5892662..5892875); ID=FBpp0087523; name=Pka-R2-PA; parent=FBgn0022382,FBtr0088437; dbxref=FlyBase:FBpp0087523,FlyBase_Annotation_IDs:CG15862-PA,GB_protein:AAF58862.2,REFSEQ:NP_523671,GB_protein:AAF58862; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:complement(5883996..5884126,5885209..5885394,5885776..5885851,5885920..5886067,5886212..5886307,5886930..5887030,5887239..5887420,5892662..5892875); ID=FBpp0087524; name=Pka-R2-PB; parent=FBgn0022382,FBtr0088438; dbxref=FlyBase:FBpp0087524,FlyBase_Annotation_IDs:CG15862-PB,GB_protein:AAM71046.3,REFSEQ:NP_724860,GB_protein:AAM71046; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:complement(5883996..5884126,5885209..5885394,5885776..5885851,5885920..5886067,5886212..5886307,5886930..5887030,5887239..5887420,5892662..5892875); ID=FBpp0087525; name=Pka-R2-PC; parent=FBgn0022382,FBtr0088439; dbxref=FlyBase:FBpp0087525,FlyBase_Annotation_IDs:CG15862-PC,GB_protein:AAO41465.1,REFSEQ:NP_788297,GB_protein:AAO41465; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:complement(5883996..5884126,5885209..5885394,5885776..5885851,5885920..5886067,5886212..5886307,5886930..5887030,5887239..5887420,5892662..5892875); ID=FBpp0087523; name=Pka-R2-PA; parent=FBgn0022382,FBtr0088437; dbxref=FlyBase:FBpp0087523,FlyBase_Annotation_IDs:CG15862-PA,GB_protein:AAF58862.2,REFSEQ:NP_523671,GB_protein:AAF58862,FlyMine:FBpp0087523,modMine:FBpp0087523; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(5883996..5884126,5885209..5885394,5885776..5885851,5885920..5886067,5886212..5886307,5886930..5887030,5887239..5887420,5892662..5892875); ID=FBpp0087524; name=Pka-R2-PB; parent=FBgn0022382,FBtr0088438; dbxref=FlyBase:FBpp0087524,FlyBase_Annotation_IDs:CG15862-PB,GB_protein:AAM71046.3,REFSEQ:NP_724860,GB_protein:AAM71046; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(10005157..10005370,9999734..9999915,9999425..9999525,9998707..9998802,9998415..9998562,9998271..9998346,9997704..9997889,9996491..9996621)); ID=FBpp0087523; name=Pka-R2-PA; parent=FBgn0022382,FBtr0088437; dbxref=FlyBase:FBpp0087523,FlyBase_Annotation_IDs:CG15862-PA,GB_protein:AAF58862.2,REFSEQ:NP_523671,GB_protein:AAF58862,FlyMine:FBpp0087523,modMine:FBpp0087523; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(10005157..10005370,9999734..9999915,9999425..9999525,9998707..9998802,9998415..9998562,9998271..9998346,9997704..9997889,9996491..9996621)); ID=FBpp0087524; name=Pka-R2-PB; parent=FBgn0022382,FBtr0088438; dbxref=FlyBase:FBpp0087524,FlyBase_Annotation_IDs:CG15862-PB,GB_protein:AAM71046.3,REFSEQ:NP_724860,GB_protein:AAM71046; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(10005157..10005370,9999734..9999915,9999425..9999525,9998707..9998802,9998415..9998562,9998271..9998346,9997704..9997889,9996491..9996621)); ID=FBpp0087523; name=Pka-R2-PA; parent=FBgn0022382,FBtr0088437; dbxref=FlyBase:FBpp0087523,FlyBase_Annotation_IDs:CG15862-PA,GB_protein:AAF58862.2,REFSEQ:NP_523671,GB_protein:AAF58862,FlyMine:FBpp0087523,modMine:FBpp0087523; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=2R:complement(join(10005157..10005370,9999734..9999915,9999425..9999525,9998707..9998802,9998415..9998562,9998271..9998346,9997704..9997889,9996491..9996621)); ID=FBpp0087524; name=Pka-R2-PB; parent=FBgn0022382,FBtr0088438; dbxref=FlyBase:FBpp0087524,FlyBase_Annotation_IDs:CG15862-PB,GB_protein:AAM71046.3,REFSEQ:NP_724860,GB_protein:AAM71046; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0087523 type=protein; loc=2R:complement(join(10005157..10005370,9999734..9999915,9999425..9999525,9998707..9998802,9998415..9998562,9998271..9998346,9997704..9997889,9996491..9996621)); ID=FBpp0087523; name=Pka-R2-PA; parent=FBgn0022382,FBtr0088437; dbxref=FlyBase:FBpp0087523,FlyBase_Annotation_IDs:CG15862-PA,GB_protein:AAF58862.2,REFSEQ:NP_523671,GB_protein:AAF58862,FlyMine:FBpp0087523,modMine:FBpp0087523; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0087524 type=protein; loc=2R:complement(join(10005157..10005370,9999734..9999915,9999425..9999525,9998707..9998802,9998415..9998562,9998271..9998346,9997704..9997889,9996491..9996621)); ID=FBpp0087524; name=Pka-R2-PB; parent=FBgn0022382,FBtr0088438; dbxref=FlyBase:FBpp0087524,FlyBase_Annotation_IDs:CG15862-PB,GB_protein:AAM71046.3,REFSEQ:NP_724860,GB_protein:AAM71046; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(10005157..10005370,9999734..9999915,9999425..9999525,9998707..9998802,9998415..9998562,9998271..9998346,9997704..9997889,9996491..9996621)); ID=FBpp0087523; name=Pka-R2-PA; parent=FBgn0022382,FBtr0088437; dbxref=FlyBase:FBpp0087523,FlyBase_Annotation_IDs:CG15862-PA,GB_protein:AAF58862.2,REFSEQ:NP_523671,GB_protein:AAF58862,UniProt/Swiss-Prot:P81900,FlyMine:FBpp0087523,modMine:FBpp0087523; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=2R:complement(join(10005157..10005370,9999734..9999915,9999425..9999525,9998707..9998802,9998415..9998562,9998271..9998346,9997704..9997889,9996491..9996621)); ID=FBpp0087524; name=Pka-R2-PB; parent=FBgn0022382,FBtr0088438; dbxref=FlyBase:FBpp0087524,FlyBase_Annotation_IDs:CG15862-PB,GB_protein:AAM71046.3,REFSEQ:NP_724860,GB_protein:AAM71046,UniProt/Swiss-Prot:P81900; MD5=791de752ffec18a32e991d2dd2070cc8; length=377; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 377 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    cAMP-dependent protein kinase complex [IEA][ISS][NAS]
    Biological Process: behavioral response to cocaine [IMP][NAS]
    locomotor rhythm [IMP][NAS]
    signal transduction [IEA]
    regulation of protein amino acid phosphorylation [IEA]
    axon guidance [IMP]
    behavioral response to ethanol [IMP][NAS][TAS]
    protein amino acid phosphorylation [ISS]
    circadian rhythm [IMP][NAS]
    rhythmic behavior [TAS]
    Molecular Function: protein binding [IPI]
    cAMP-dependent protein kinase regulator activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDSSRRIQ VPEELKEVLL QFSISFLVEQ PPDVIDYAVE YFTKLQSERP SVSHTDQSTD  60
   61 DQLSVNSQDA DAEPPVMASS RRKSVFAEAY DPEADDDDDG ATAVFPKTDE QRARLVESVK 120
  121 NVLLFRSLEK EQMNQVLDAM FERKVQPGDF IIRQGDDGDN FYVIESGVYK VYINDKHINT 180
  181 YNHTGLFGEL ALLYNMPRAA TVQAETSGLL WAMDRQTFRR ILLKSAFRKR KMYEELLNSV 240
  241 PMLKALQNYE RMNLADALVS KSYDNGERII KQGDAADGMY FIEEGTVSVR MDQDDAEVEI 300
  301 SQLGKGQYFG ELALVTHRPR AASVYATGGV VKLAFLDVKA FERLLGPCMD IMKRNIDDYE 360
  361 SQLVKIFGSK NNITDTR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..71] FFAS03 3.18 No description for 2izyA was found.
    2 View Details [72..377] PSI-BLAST 51.0 Regulatory subunit of Protein kinase A

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • gated channel activity
    		•  3.75615867846417 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.71111882888041 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.71111882888041 bayes_pls_golite062009
  • cation channel activity
    		•  3.61025292543387 bayes_pls_golite062009
  • ion channel activity
    		•  3.49583875363169 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  2.99565487349638 bayes_pls_golite062009
  • transporter activity
    		•  2.8998330876169 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.85192191539872 bayes_pls_golite062009
  • cAMP-dependent protein kinase regulator activity
    		•  2.78017841119787 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.66890994787635 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  2.66781824266082 bayes_pls_golite062009
  • channel activity
    		•  2.66781824266082 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.64973131242976 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.62037413430064 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.28218867890883 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.24699267672716 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.97137082688083 bayes_pls_golite062009
  • binding
    		•  1.80151718402565 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  1.68618484766279 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.62633054482127 bayes_pls_golite062009
  • DNA binding
    		•  1.54942974151543 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.40720858109605 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.29733029674587 bayes_pls_golite062009
  • signal transducer activity
    		•  1.29733029674587 bayes_pls_golite062009
  • cyclic nucleotide-gated ion channel activity
    		•  1.26984296847489 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  1.26984296847489 bayes_pls_golite062009
  • transcription factor activity
    		•  1.14697837766975 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.944734749939467 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.930640481652164 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  0.921648634540942 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.910527807644534 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.848189810874263 bayes_pls_golite062009
  • protein binding
    		•  0.81302068072988 bayes_pls_golite062009
  • nucleotide binding
    		•  0.274529576258456 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.26553997342843 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.26063388960068 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0296966221249605 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0295376254112757 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.025744194913981 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle