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Protein Overview: FKBP4

General Information:
Name(s) found: FKBP4 [HGNC (HUGO)]
Description(s) found:
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  • gi|4503729|ref|NP_002005.1| FK506 binding protein 52 [Homo sapiens] [NCBI NR]
  • pir||A46372 immunophilin FKBP52 - human [NCBI NR]
  • gi|399866|sp|Q02790.3|FKBP4_HUMAN RecName: Full=FK506-binding protein 4; AltName: Full=Peptidyl-prolyl cis-trans isomerase; Short=PPIase; Short=Rotamase; AltName: Full=HSP-binding immunophilin; Short=HBI; AltName: Full=FKBP52 protein; AltName: Full=52 kDa [NCBI NR]
  • gi|186390|gb|AAA36111.1| 'FKBP52; 52 kD FK506 binding protein' [NCBI NR]
  • gi|14043983|gb|AAH07924.1| FK506 binding protein 4, 59kDa [Homo sapiens] [NCBI NR]
  • gi|12804711|gb|AAH01786.1| FK506 binding protein 4, 59kDa [Homo sapiens] [NCBI NR]
  • gi|119609296|gb|EAW88890.1| FK506 binding protein 4, 59kDa, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119609295|gb|EAW88889.1| FK506 binding protein 4, 59kDa, isoform CRA_a [Homo sapiens] [NCBI NR]
  • FK506 binding protein 4, 59kDa [HGNC (HUGO)]
  • Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens GN=FKBP4 PE=1 SV=3 [Swiss-Prot]
  • FK506-binding protein 4 [hmr_yeast5_DM3-1_pombe.fasta]
  • FK506-binding protein 4; FK506-binding protein 4 (59kD); T-cell FK506-binding protein, 59kD; p59 protein; HSP binding immunophilin; peptidylprolyl cis-trans isomerase; rotamase; FK506 binding protein 4 (59kD) [HMR_022704.fasta]
  • FK506-binding protein 4; FK506-binding protein 4 (59kD); FK506 binding protein 4 (59kD); T-cell FK506-binding protein, 59kD; p59 protein; HSP binding immunophilin; peptidylprolyl cis-trans isomerase; rotamase [Human2242005.fasta]
  • FK506-binding protein 4 [Homo sapiens]gi|12804711|gb|AAH01786.1| FK506-binding protein 4 [Homo sapiens]gi|14043983|gb|AAH07924.1| FK506-binding protein 4 [Homo sapiens]gi|422824|pir||A46372 immunophilin FKBP52 - humangi|186390|gb|AAA36111.1| 'FKBP52; [nrdb_11152004_Chlamydomonas]
  • FK506-binding protein 4 (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (p59 protein) (HSP binding immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506 binding protein) (FKBP59) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • (NM_002014) FK506-binding protein 4; FK506-binding protein 4 (59kD); T-cell FK506-binding protein, 59kD; p59 protein; HSP binding immunophilin; peptidylprolyl cis-trans isomerase; rotamase [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • FK506-binding protein 4 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 FK506-binding protein 4 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • FK506-binding protein 4; FK506-binding protein 4 (59kD); FK506 binding protein 4 (59kD); T-cell FK506-binding protein, 59kD; p59 protein; HSP binding immunophilin; peptidylprolyl cis-trans isomerase; rotamase [Homo sapiens] [HumanGallus06162005.fasta]
  • FK506-binding protein 4; FK506-binding protein 4 (59kD); T-cell FK506-binding protein, 59kD; p59 protein; HSP binding immunophilin; peptidylprolyl cis-trans isomerase; rotamase; FK506 binding protein 4 (59kD) [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • FK506-binding protein 4 (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (HSP-binding immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506-binding protein) (FKBP59) (p59 protein) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • FK506 binding protein 4, 59kDa, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • FK506 binding protein 4, 59kDa [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 'FKBP52; 52 kD FK506 binding protein' [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 FK506-BINDING PROTEIN 4 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • FK506 binding protein 52 [Homo sapiens] [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=FKBP4 FK506-binding protein 4 [human-ipi-250309-contam.fasta]
  • FK506-binding protein 4 (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (p59 protein) (HSP-binding immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506-binding protein) (FKBP59) [nr-271106-contam.fasta]
  • IPI:IPI00219005.3|SWISS-PROT:Q02790|TREMBL:B2R9U2|ENSEMBL:ENSP00000001008|REFSEQ:NP_002005|H-INV:HIT000030649|VEGA:OTTHUMP00000115497;OTTHUMP00000166201 Tax_Id=9606 Gene_Symbol=FKBP4 FK506-binding protein 4 [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 FK506-binding protein 4 [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=FKBP4 FK506-binding protein 4 ENSG00000004478 IPI00219005 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4 [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta]
  • peptidyl-prolyl cis-trans isomerase FKBP4 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q02790;Q9UCP1;Q9UCV7; RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4; AltName: Full=FK506-binding protein 4; AltName: Full=Rotamase; AltName: Full=HSP-binding immunophilin; AltName: Full=Immunophilin FKBP52; AltName: Full=52 kDa FK506-binding protein; AltName: Full=59 kDa immunophilin; AltName: Full=FKBP59; Contains: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens GN=FKBP4 [011711_HMR.fasta]
  • IPI:IPI00219005.3|SWISS-PROT:Q02790|TREMBL:B2R9U2;D3DUQ1|ENSEMBL:ENSP00000001008|REFSEQ:NP_002005|H-INV:HIT000030649|VEGA:OTTHUMP00000115497;OTTHUMP00000166201 Tax_Id=9606 Gene_Symbol=FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=FKBP4 Synonyms=FKBP51|FKBP52|FKBP59|HBI|Hsp56|PPIase|p52 peptidyl-prolyl cis-trans isomerase FKBP4 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00219005.3|SWISS-PROT:Q02790|TREMBL:B2R9U2|ENSEMBL:ENSP00000001008|REFSEQ:NP_002005|H-INV:HIT000030649|VEGA:OTTHUMP00000115497 Tax_Id=9606 Gene_Symbol=FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4 [ipi.HUMAN.20110912.fasta]
  • Peptidyl-prolyl cis-trans isomerase FKBP4 GN=FKBP4 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 459 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW  60
   61 LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGSPP 120
  121 KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIQTRGEG YAKPNEGAIV EVALEGYYKD 180
  181 KLFDQRELRF EIGEGENLDL PYGLERAIQR MEKGEHSIVY LKPSYAFGSV GKEKFQIPPN 240
  241 AELKYELHLK SFEKAKESWE MNSEEKLEQS TIVKERGTVY FKEGKYKQAL LQYKKIVSWL 300
  301 EYESSFSNEE AQKAQALRLA SHLNLAMCHL KLQAFSAAIE SCNKALELDS NNEKGLFRRG 360
  361 EAHLAVNDFE LARADFQKVL QLYPNNKAAK TQLAVCQQRI RRQLAREKKL YANMFERLAE 420
  421 EENKAKAEAS SGDHPTDTEM KEEQKSNTAG SQSQVETEA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..118] PSI-BLAST 26.69897 FKBP52, N-terminal domain
    2 View Details [119..316] FFAS03 4.95 FKBP51, C-terminal domain; FKBP51, N-terminal domains
    3 View Details [317..459] PSI-BLAST 27.30103 Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ryanodine-sensitive calcium-release channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • intracellular ligand-gated calcium channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • macrolide binding
    		•  7.31599503004442 bayes_pls_golite062009
  • FK506 binding
    		•  7.22442625476031 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.74926751944787 bayes_pls_golite062009
  • calcium channel activity
    		•  6.4374377859142 bayes_pls_golite062009
  • cation channel activity
    		•  6.06732269872248 bayes_pls_golite062009
  • ion channel activity
    		•  5.45007096522107 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  5.32426176964634 bayes_pls_golite062009
  • channel activity
    		•  5.32426176964634 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  5.28960420749143 bayes_pls_golite062009
  • gated channel activity
    		•  5.28074654906904 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.99265212272703 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.6566793500337 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.61794461605199 bayes_pls_golite062009
  • calcium-release channel activity
    		•  2.58969194870156 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.47257819150887 bayes_pls_golite062009
  • isomerase activity
    		•  2.31710030777753 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.85589011277711 bayes_pls_golite062009
  • receptor activity
    		•  1.78361575899771 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.7459556028988 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68688812199737 bayes_pls_golite062009
  • kinase activity
    		•  1.67904764195462 bayes_pls_golite062009
  • binding
    		•  1.63170667962375 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57898291235576 bayes_pls_golite062009
  • signal transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • protein kinase activity
    		•  1.45320632553313 bayes_pls_golite062009
  • drug binding
    		•  1.39643621593407 bayes_pls_golite062009
  • transferase activity
    		•  1.34122735969662 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  1.32709321745178 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  1.32470025150272 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  1.32470025150272 bayes_pls_golite062009
  • transporter activity
    		•  1.25197125648774 bayes_pls_golite062009
  • protein binding
    		•  1.08765413491791 bayes_pls_golite062009
  • SMAD binding
    		•  1.04905381164355 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03909235910355 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.789390402522536 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.763739321802433 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.763739321802433 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  0.727019445105701 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.671059013500415 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.525950701946406 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.27473817613726 bayes_pls_golite062009
  • activin binding
    		•  0.262691232876501 bayes_pls_golite062009
  • histone binding
    		•  0.221748741603068 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.21145105012677 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ryanodine-sensitive calcium-release channel activity
    		•  10.5818680850178 bayes_pls_golite062009
  • intracellular ligand-gated calcium channel activity
    		•  10.5818680850178 bayes_pls_golite062009
  • macrolide binding
    		•  6.76364038125885 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.73398709732238 bayes_pls_golite062009
  • FK506 binding
    		•  6.68168417220699 bayes_pls_golite062009
  • procollagen-proline 4-dioxygenase activity
    		•  6.33141891074556 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
    		•  6.33141891074556 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  6.33141891074556 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  6.33141891074556 bayes_pls_golite062009
  • calcium channel activity
    		•  6.26093539961789 bayes_pls_golite062009
  • cation channel activity
    		•  6.02454701753153 bayes_pls_golite062009
  • protein phosphatase 2A binding
    		•  5.70177601384074 bayes_pls_golite062009
  • ion channel activity
    		•  5.41446659728328 bayes_pls_golite062009
  • channel activity
    		•  5.29566611694414 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  5.29566611694414 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  5.25915730995039 bayes_pls_golite062009
  • gated channel activity
    		•  5.23693345098661 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    		•  4.40754649831781 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  3.47347683498372 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.41272339669823 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.27653035675626 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.27653035675626 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.66103271426565 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.61980214265117 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.48031953795714 bayes_pls_golite062009
  • phosphatase activity
    		•  2.44706583719107 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.38926130931194 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.32557041601016 bayes_pls_golite062009
  • calcium-release channel activity
    		•  2.24272229394245 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.09150703279726 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.08144339124986 bayes_pls_golite062009
  • isomerase activity
    		•  1.92777278447686 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83171242300949 bayes_pls_golite062009
  • receptor activity
    		•  1.78786100885722 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.75042985427656 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.6949579078176 bayes_pls_golite062009
  • kinase activity
    		•  1.68748031932496 bayes_pls_golite062009
  • binding
    		•  1.66926716799278 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.58792227723443 bayes_pls_golite062009
  • signal transducer activity
    		•  1.54949624451448 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.54949624451448 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  1.48932763287956 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4606316161198 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.42907226857237 bayes_pls_golite062009
  • transferase activity
    		•  1.35149948487544 bayes_pls_golite062009
  • DNA binding
    		•  1.32823848889363 bayes_pls_golite062009
  • transporter activity
    		•  1.26515051009051 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  1.25364237438323 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  1.24715902371406 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  1.24715902371406 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  1.1910515648311 bayes_pls_golite062009
  • protein binding
    		•  1.13205057608753 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.05129296782391 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.03214696367403 bayes_pls_golite062009
  • drug binding
    		•  1.02692887826597 bayes_pls_golite062009
  • heat shock protein binding
    		•  0.974870566753586 bayes_pls_golite062009
  • SMAD binding
    		•  0.923832336018678 bayes_pls_golite062009
  • transcription activator activity
    		•  0.865375739926993 bayes_pls_golite062009
  • catalytic activity
    		•  0.838457647933563 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.831782705534701 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.7991885026596 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.7429757196483 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.713457194766522 bayes_pls_golite062009
  • transcription factor activity
    		•  0.679223944174373 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.679185625455585 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.679185625455585 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.676568185178303 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  0.620169189588866 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  0.599036230630856 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  0.547008204307472 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  0.513111849696122 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.510792404154917 bayes_pls_golite062009
  • enzyme binding
    		•  0.335436488591595 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.23321005341344 bayes_pls_golite062009
  • transcription factor binding
    		•  0.202402797164729 bayes_pls_golite062009
  • hydrolase activity
    		•  0.191714540920279 bayes_pls_golite062009
  • histone binding
    		•  0.187349169865552 bayes_pls_golite062009
  • activin binding
    		•  0.155745749643662 bayes_pls_golite062009
  • signal sequence binding
    		•  0.144756387712192 bayes_pls_golite062009
  • superoxide-generating NADPH oxidase activity
    		•  0.0442139417921878 bayes_pls_golite062009
    3
    Term Confidence Notes
  • intracellular ligand-gated calcium channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • ryanodine-sensitive calcium-release channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • macrolide binding
    		•  7.31599503004442 bayes_pls_golite062009
  • FK506 binding
    		•  7.22442625476031 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  6.80616214194201 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
    		•  6.80616214194201 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  6.80616214194201 bayes_pls_golite062009
  • procollagen-proline 4-dioxygenase activity
    		•  6.80616214194201 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.74926751944787 bayes_pls_golite062009
  • calcium channel activity
    		•  6.4374377859142 bayes_pls_golite062009
  • cation channel activity
    		•  6.06732269872248 bayes_pls_golite062009
  • protein phosphatase 2A binding
    		•  6.03345119957353 bayes_pls_golite062009
  • ion channel activity
    		•  5.45007096522107 bayes_pls_golite062009
  • channel activity
    		•  5.32426176964634 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  5.32426176964634 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  5.28960420749143 bayes_pls_golite062009
  • gated channel activity
    		•  5.28074654906904 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    		•  4.77770372249654 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.99265212272703 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.6566793500337 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.61794461605199 bayes_pls_golite062009
  • calcium-release channel activity
    		•  2.58969194870156 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.47257819150887 bayes_pls_golite062009
  • phosphatase activity
    		•  2.4502869290841 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.38923256228405 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.35894350869919 bayes_pls_golite062009
  • isomerase activity
    		•  2.31710030777753 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.12083180880718 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.07186557005331 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.85589011277711 bayes_pls_golite062009
  • receptor activity
    		•  1.78361575899771 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.7459556028988 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68688812199737 bayes_pls_golite062009
  • kinase activity
    		•  1.67904764195462 bayes_pls_golite062009
  • binding
    		•  1.63170667962375 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57898291235576 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • signal transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  1.5101001424727 bayes_pls_golite062009
  • protein kinase activity
    		•  1.45320632553313 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.4415534360016 bayes_pls_golite062009
  • drug binding
    		•  1.39643621593407 bayes_pls_golite062009
  • heat shock protein binding
    		•  1.35268080101836 bayes_pls_golite062009
  • transferase activity
    		•  1.34122735969662 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  1.32709321745178 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  1.32470025150272 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  1.32470025150272 bayes_pls_golite062009
  • DNA binding
    		•  1.31957293306432 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  1.26630556032955 bayes_pls_golite062009
  • transporter activity
    		•  1.25197125648774 bayes_pls_golite062009
  • protein binding
    		•  1.08765413491791 bayes_pls_golite062009
  • SMAD binding
    		•  1.04905381164355 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03909235910355 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.01193875360949 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • transcription activator activity
    		•  0.873307397500777 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.841959344808827 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.789390402522536 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.780875583795532 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  0.777060600234881 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.763739321802433 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.763739321802433 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.761034574704448 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  0.727019445105701 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  0.683689287992235 bayes_pls_golite062009
  • transcription factor activity
    		•  0.672036990681626 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.671059013500415 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  0.625352830428438 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.525950701946406 bayes_pls_golite062009
  • signal sequence binding
    		•  0.49295886046194 bayes_pls_golite062009
  • enzyme binding
    		•  0.44905827271946 bayes_pls_golite062009
  • superoxide-generating NADPH oxidase activity
    		•  0.37588912752498 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.27473817613726 bayes_pls_golite062009
  • transcription factor binding
    		•  0.273314664611729 bayes_pls_golite062009
  • activin binding
    		•  0.262691232876501 bayes_pls_golite062009
  • histone binding
    		•  0.221748741603068 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.21145105012677 bayes_pls_golite062009
  • hydrolase activity
    		•  0.172906111259113 bayes_pls_golite062009
  • peroxisome targeting sequence binding
    		•  0.0468412220974996 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor
    		•  0.0437303095920707 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.0131115480611301 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle