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Protein Overview: FKBP4

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data


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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#   Region(s) Method Confidence Match Description
1 View Details [1..118] PSI-BLAST 26.69897 FKBP52, N-terminal domain
2 View Details [119..316] FFAS03 4.95 FKBP51, C-terminal domain; FKBP51, N-terminal domains
3 View Details [317..459] PSI-BLAST 27.30103 Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90

Functions predicted (by domain):

# Gene Ontology predictions
1
Term Confidence Notes
  • ryanodine-sensitive calcium-release channel activity
  • 10.9968443145942 bayes_pls_golite062009
  • intracellular ligand-gated calcium channel activity
  • 10.9968443145942 bayes_pls_golite062009
  • macrolide binding
  • 7.31599503004442 bayes_pls_golite062009
  • FK506 binding
  • 7.22442625476031 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
  • 6.74926751944787 bayes_pls_golite062009
  • calcium channel activity
  • 6.4374377859142 bayes_pls_golite062009
  • cation channel activity
  • 6.06732269872248 bayes_pls_golite062009
  • ion channel activity
  • 5.45007096522107 bayes_pls_golite062009
  • passive transmembrane transporter activity
  • 5.32426176964634 bayes_pls_golite062009
  • channel activity
  • 5.32426176964634 bayes_pls_golite062009
  • substrate-specific channel activity
  • 5.28960420749143 bayes_pls_golite062009
  • gated channel activity
  • 5.28074654906904 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
  • 4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
  • 3.99265212272703 bayes_pls_golite062009
  • ligand-gated channel activity
  • 3.34717828007833 bayes_pls_golite062009
  • ligand-gated ion channel activity
  • 3.34717828007833 bayes_pls_golite062009
  • ion transmembrane transporter activity
  • 2.6566793500337 bayes_pls_golite062009
  • cation transmembrane transporter activity
  • 2.61794461605199 bayes_pls_golite062009
  • calcium-release channel activity
  • 2.58969194870156 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
  • 2.47257819150887 bayes_pls_golite062009
  • isomerase activity
  • 2.31710030777753 bayes_pls_golite062009
  • transcription regulator activity
  • 1.85589011277711 bayes_pls_golite062009
  • receptor activity
  • 1.78361575899771 bayes_pls_golite062009
  • transmembrane receptor activity
  • 1.7459556028988 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
  • 1.68688812199737 bayes_pls_golite062009
  • kinase activity
  • 1.67904764195462 bayes_pls_golite062009
  • binding
  • 1.63170667962375 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
  • 1.57898291235576 bayes_pls_golite062009
  • signal transducer activity
  • 1.53711974553033 bayes_pls_golite062009
  • molecular transducer activity
  • 1.53711974553033 bayes_pls_golite062009
  • protein kinase activity
  • 1.45320632553313 bayes_pls_golite062009
  • drug binding
  • 1.39643621593407 bayes_pls_golite062009
  • transferase activity
  • 1.34122735969662 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
  • 1.32709321745178 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
  • 1.32470025150272 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
  • 1.32470025150272 bayes_pls_golite062009
  • transporter activity
  • 1.25197125648774 bayes_pls_golite062009
  • protein binding
  • 1.08765413491791 bayes_pls_golite062009
  • SMAD binding
  • 1.04905381164355 bayes_pls_golite062009
  • transmembrane transporter activity
  • 1.03909235910355 bayes_pls_golite062009
  • catalytic activity
  • 0.885282592863018 bayes_pls_golite062009
  • substrate-specific transporter activity
  • 0.789390402522536 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
  • 0.763739321802433 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
  • 0.763739321802433 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
  • 0.727019445105701 bayes_pls_golite062009
  • protein serine/threonine kinase activity
  • 0.671059013500415 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
  • 0.525950701946406 bayes_pls_golite062009
  • unfolded protein binding
  • 0.27473817613726 bayes_pls_golite062009
  • activin binding
  • 0.262691232876501 bayes_pls_golite062009
  • histone binding
  • 0.221748741603068 bayes_pls_golite062009
  • transcription elongation regulator activity
  • 0.21145105012677 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ryanodine-sensitive calcium-release channel activity
  • 10.5818680850178 bayes_pls_golite062009
  • intracellular ligand-gated calcium channel activity
  • 10.5818680850178 bayes_pls_golite062009
  • macrolide binding
  • 6.76364038125885 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
  • 6.73398709732238 bayes_pls_golite062009
  • FK506 binding
  • 6.68168417220699 bayes_pls_golite062009
  • procollagen-proline 4-dioxygenase activity
  • 6.33141891074556 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
  • 6.33141891074556 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
  • 6.33141891074556 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
  • 6.33141891074556 bayes_pls_golite062009
  • calcium channel activity
  • 6.26093539961789 bayes_pls_golite062009
  • cation channel activity
  • 6.02454701753153 bayes_pls_golite062009
  • protein phosphatase 2A binding
  • 5.70177601384074 bayes_pls_golite062009
  • ion channel activity
  • 5.41446659728328 bayes_pls_golite062009
  • channel activity
  • 5.29566611694414 bayes_pls_golite062009
  • passive transmembrane transporter activity
  • 5.29566611694414 bayes_pls_golite062009
  • substrate-specific channel activity
  • 5.25915730995039 bayes_pls_golite062009
  • gated channel activity
  • 5.23693345098661 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
  • 4.40754649831781 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
  • 3.47347683498372 bayes_pls_golite062009
  • cis-trans isomerase activity
  • 3.41272339669823 bayes_pls_golite062009
  • ligand-gated channel activity
  • 3.27653035675626 bayes_pls_golite062009
  • ligand-gated ion channel activity
  • 3.27653035675626 bayes_pls_golite062009
  • ion transmembrane transporter activity
  • 2.66103271426565 bayes_pls_golite062009
  • cation transmembrane transporter activity
  • 2.61980214265117 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
  • 2.48031953795714 bayes_pls_golite062009
  • phosphatase activity
  • 2.44706583719107 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
  • 2.38926130931194 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
  • 2.32557041601016 bayes_pls_golite062009
  • calcium-release channel activity
  • 2.24272229394245 bayes_pls_golite062009
  • small conjugating protein ligase activity
  • 2.09150703279726 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
  • 2.08144339124986 bayes_pls_golite062009
  • isomerase activity
  • 1.92777278447686 bayes_pls_golite062009
  • transcription regulator activity
  • 1.83171242300949 bayes_pls_golite062009
  • receptor activity
  • 1.78786100885722 bayes_pls_golite062009
  • transmembrane receptor activity
  • 1.75042985427656 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
  • 1.6949579078176 bayes_pls_golite062009
  • kinase activity
  • 1.68748031932496 bayes_pls_golite062009
  • binding
  • 1.66926716799278 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
  • 1.58792227723443 bayes_pls_golite062009
  • signal transducer activity
  • 1.54949624451448 bayes_pls_golite062009
  • molecular transducer activity
  • 1.54949624451448 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
  • 1.48932763287956 bayes_pls_golite062009
  • protein kinase activity
  • 1.4606316161198 bayes_pls_golite062009
  • acid-amino acid ligase activity
  • 1.42907226857237 bayes_pls_golite062009
  • transferase activity
  • 1.35149948487544 bayes_pls_golite062009
  • DNA binding
  • 1.32823848889363 bayes_pls_golite062009
  • transporter activity
  • 1.26515051009051 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
  • 1.25364237438323 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
  • 1.24715902371406 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
  • 1.24715902371406 bayes_pls_golite062009
  • steroid hormone receptor binding
  • 1.1910515648311 bayes_pls_golite062009
  • protein binding
  • 1.13205057608753 bayes_pls_golite062009
  • transmembrane transporter activity
  • 1.05129296782391 bayes_pls_golite062009
  • nucleic acid binding
  • 1.03214696367403 bayes_pls_golite062009
  • drug binding
  • 1.02692887826597 bayes_pls_golite062009
  • heat shock protein binding
  • 0.974870566753586 bayes_pls_golite062009
  • SMAD binding
  • 0.923832336018678 bayes_pls_golite062009
  • transcription activator activity
  • 0.865375739926993 bayes_pls_golite062009
  • catalytic activity
  • 0.838457647933563 bayes_pls_golite062009
  • transcription repressor activity
  • 0.831782705534701 bayes_pls_golite062009
  • substrate-specific transporter activity
  • 0.7991885026596 bayes_pls_golite062009
  • hormone receptor binding
  • 0.7429757196483 bayes_pls_golite062009
  • nuclear hormone receptor binding
  • 0.713457194766522 bayes_pls_golite062009
  • transcription factor activity
  • 0.679223944174373 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
  • 0.679185625455585 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
  • 0.679185625455585 bayes_pls_golite062009
  • protein serine/threonine kinase activity
  • 0.676568185178303 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
  • 0.620169189588866 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
  • 0.599036230630856 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
  • 0.547008204307472 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
  • 0.513111849696122 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
  • 0.510792404154917 bayes_pls_golite062009
  • enzyme binding
  • 0.335436488591595 bayes_pls_golite062009
  • unfolded protein binding
  • 0.23321005341344 bayes_pls_golite062009
  • transcription factor binding
  • 0.202402797164729 bayes_pls_golite062009
  • hydrolase activity
  • 0.191714540920279 bayes_pls_golite062009
  • histone binding
  • 0.187349169865552 bayes_pls_golite062009
  • activin binding
  • 0.155745749643662 bayes_pls_golite062009
  • signal sequence binding
  • 0.144756387712192 bayes_pls_golite062009
  • superoxide-generating NADPH oxidase activity
  • 0.0442139417921878 bayes_pls_golite062009
    3
    Term Confidence Notes
  • intracellular ligand-gated calcium channel activity
  • 10.9968443145942 bayes_pls_golite062009
  • ryanodine-sensitive calcium-release channel activity
  • 10.9968443145942 bayes_pls_golite062009
  • macrolide binding
  • 7.31599503004442 bayes_pls_golite062009
  • FK506 binding
  • 7.22442625476031 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
  • 6.80616214194201 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
  • 6.80616214194201 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
  • 6.80616214194201 bayes_pls_golite062009
  • procollagen-proline 4-dioxygenase activity
  • 6.80616214194201 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
  • 6.74926751944787 bayes_pls_golite062009
  • calcium channel activity
  • 6.4374377859142 bayes_pls_golite062009
  • cation channel activity
  • 6.06732269872248 bayes_pls_golite062009
  • protein phosphatase 2A binding
  • 6.03345119957353 bayes_pls_golite062009
  • ion channel activity
  • 5.45007096522107 bayes_pls_golite062009
  • channel activity
  • 5.32426176964634 bayes_pls_golite062009
  • passive transmembrane transporter activity
  • 5.32426176964634 bayes_pls_golite062009
  • substrate-specific channel activity
  • 5.28960420749143 bayes_pls_golite062009
  • gated channel activity
  • 5.28074654906904 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
  • 4.77770372249654 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
  • 4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
  • 3.99265212272703 bayes_pls_golite062009
  • ligand-gated ion channel activity
  • 3.34717828007833 bayes_pls_golite062009
  • ligand-gated channel activity
  • 3.34717828007833 bayes_pls_golite062009
  • ion transmembrane transporter activity
  • 2.6566793500337 bayes_pls_golite062009
  • cation transmembrane transporter activity
  • 2.61794461605199 bayes_pls_golite062009
  • calcium-release channel activity
  • 2.58969194870156 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
  • 2.47257819150887 bayes_pls_golite062009
  • phosphatase activity
  • 2.4502869290841 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
  • 2.38923256228405 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
  • 2.35894350869919 bayes_pls_golite062009
  • isomerase activity
  • 2.31710030777753 bayes_pls_golite062009
  • small conjugating protein ligase activity
  • 2.12083180880718 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
  • 2.07186557005331 bayes_pls_golite062009
  • transcription regulator activity
  • 1.85589011277711 bayes_pls_golite062009
  • receptor activity
  • 1.78361575899771 bayes_pls_golite062009
  • transmembrane receptor activity
  • 1.7459556028988 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
  • 1.68688812199737 bayes_pls_golite062009
  • kinase activity
  • 1.67904764195462 bayes_pls_golite062009
  • binding
  • 1.63170667962375 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
  • 1.57898291235576 bayes_pls_golite062009
  • molecular transducer activity
  • 1.53711974553033 bayes_pls_golite062009
  • signal transducer activity
  • 1.53711974553033 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
  • 1.5101001424727 bayes_pls_golite062009
  • protein kinase activity
  • 1.45320632553313 bayes_pls_golite062009
  • acid-amino acid ligase activity
  • 1.4415534360016 bayes_pls_golite062009
  • drug binding
  • 1.39643621593407 bayes_pls_golite062009
  • heat shock protein binding
  • 1.35268080101836 bayes_pls_golite062009
  • transferase activity
  • 1.34122735969662 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
  • 1.32709321745178 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
  • 1.32470025150272 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
  • 1.32470025150272 bayes_pls_golite062009
  • DNA binding
  • 1.31957293306432 bayes_pls_golite062009
  • steroid hormone receptor binding
  • 1.26630556032955 bayes_pls_golite062009
  • transporter activity
  • 1.25197125648774 bayes_pls_golite062009
  • protein binding
  • 1.08765413491791 bayes_pls_golite062009
  • SMAD binding
  • 1.04905381164355 bayes_pls_golite062009
  • transmembrane transporter activity
  • 1.03909235910355 bayes_pls_golite062009
  • nucleic acid binding
  • 1.01193875360949 bayes_pls_golite062009
  • catalytic activity
  • 0.885282592863018 bayes_pls_golite062009
  • transcription activator activity
  • 0.873307397500777 bayes_pls_golite062009
  • transcription repressor activity
  • 0.841959344808827 bayes_pls_golite062009
  • substrate-specific transporter activity
  • 0.789390402522536 bayes_pls_golite062009
  • hormone receptor binding
  • 0.780875583795532 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
  • 0.777060600234881 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
  • 0.763739321802433 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
  • 0.763739321802433 bayes_pls_golite062009
  • nuclear hormone receptor binding
  • 0.761034574704448 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
  • 0.727019445105701 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
  • 0.683689287992235 bayes_pls_golite062009
  • transcription factor activity
  • 0.672036990681626 bayes_pls_golite062009
  • protein serine/threonine kinase activity
  • 0.671059013500415 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
  • 0.625352830428438 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
  • 0.525950701946406 bayes_pls_golite062009
  • signal sequence binding
  • 0.49295886046194 bayes_pls_golite062009
  • enzyme binding
  • 0.44905827271946 bayes_pls_golite062009
  • superoxide-generating NADPH oxidase activity
  • 0.37588912752498 bayes_pls_golite062009
  • unfolded protein binding
  • 0.27473817613726 bayes_pls_golite062009
  • transcription factor binding
  • 0.273314664611729 bayes_pls_golite062009
  • activin binding
  • 0.262691232876501 bayes_pls_golite062009
  • histone binding
  • 0.221748741603068 bayes_pls_golite062009
  • transcription elongation regulator activity
  • 0.21145105012677 bayes_pls_golite062009
  • hydrolase activity
  • 0.172906111259113 bayes_pls_golite062009
  • peroxisome targeting sequence binding
  • 0.0468412220974996 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor
  • 0.0437303095920707 bayes_pls_golite062009
  • transcription cofactor activity
  • 0.0131115480611301 bayes_pls_golite062009




    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)


    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle