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Protein Overview: TPT1

General Information:
Name(s) found: TPT1 / YOL102C [SGD]
Description(s) found:
Found 26 descriptions.
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  • tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 230 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    Biological Process: tRNA splicing, via endonucleolytic cleavage and ligation [IDALink to PubMed article]
    Molecular Function: tRNA 2'-phosphotransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRQVLQKDKR DVQLSKALSY LLRHTAVKEK LTIDSNGYTP LKELLSHNRL KTHKCTVDDI  60
   61 HRIVKENDKQ RFHIKTLGAD EEWICATQGH SIKSIQPSDE VLVPITEASQ LPQELIHGTN 120
  121 LQSVIKIIES GAISPMSRNH VHLSPGMLHA KGVISGMRSS SNVYIFIDCH SPLFFQTLKM 180
  181 FRSLNNVYLS SSIPVELIQK VVVKGNLKDE EKLDTLRRIL HERNIPLEKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) LOS1 SEN15 SEN2 SEN34 SEN54 STP1 STP2 STP3 STP4 TPT1 TRL1
    View Details Ho Y, et al. (2002) KRE33 NOP1 RPF2 TPT1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TPT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..230] Pfam 31.008774 RNA 2'-phosphotransferase, Tpt1 / KptA family No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transferase activity, transferring pentosyl groups
    		•  3.32684164956045 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  3.05863250787371 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  2.37948308090148 bayes_pls_golite062009
  • binding
    		•  1.5526011325617 bayes_pls_golite062009
  • transferase activity
    		•  1.5222353301058 bayes_pls_golite062009
  • DNA binding
    		•  1.26521338734397 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.22968208666588 bayes_pls_golite062009
  • catalytic activity
    		•  0.886617552734979 bayes_pls_golite062009
  • protein binding
    		•  0.847020402509418 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle