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View Structure Prediction Details

Protein: TPT1
Organism: Saccharomyces cerevisiae
Length: 230 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPT1.

Description E-value Query
Range
Subject
Range
TPT1_YEAST - tRNA 2'-phosphotransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPT1 PE=1 SV=...
TPT1 - tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-...
2.0E-78 [1..230] [1..230]
KPTA_THEAC - Probable RNA 2'-phosphotransferase OS=Thermoplasma acidophilum GN=kptA PE=3 SV=2
KPTA_THEAC - Probable RNA 2'-phosphotransferase OS=Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9...
1.0E-57 [3..224] [24..231]
KPTA_THEVO - Probable RNA 2'-phosphotransferase OS=Thermoplasma volcanium GN=kptA PE=3 SV=1
KPTA_THEVO - Probable RNA 2'-phosphotransferase OS=Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 957...
6.0E-57 [3..224] [24..231]
KPTA_PYRHO - Probable RNA 2'-phosphotransferase OS=Pyrococcus horikoshii GN=kptA PE=3 SV=1
KPTA_PYRHO - Probable RNA 2'-phosphotransferase OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 99...
7.0E-56 [11..202] [2..177]
KPTA_PYRAB - Probable RNA 2'-phosphotransferase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=kptA PE=3 SV=1
KPTA_PYRAB - Probable RNA 2'-phosphotransferase OS=Pyrococcus abyssi GN=kptA PE=3 SV=1
2.0E-55 [8..198] [5..179]
KPTA_THEAC - Probable RNA 2'-phosphotransferase OS=Thermoplasma acidophilum GN=kptA PE=3 SV=2
KPTA_THEAC - Probable RNA 2'-phosphotransferase OS=Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9...
2.0E-55 [6..224] [1..205]
SPAC2C4.12c - tRNA 2'-phosphotransferase Tpt1
TPT1_SCHPO - Putative tRNA 2'-phosphotransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC2C...
8.0E-55 [10..217] [33..231]
gi|25520148, gi|... - gi|25524258|pir||AE2997 conserved hypothetical protein Atu3583 [imported] - Agrobacterium tumefacien...
KPTA_AGRFC - Probable RNA 2'-phosphotransferase OS=Agrobacterium fabrum (strain C58 / ATCC 33970) GN=kptA PE=3 SV...
1.0E-54 [12..199] [3..175]
KPTA_FUSNN - Probable RNA 2'-phosphotransferase OS=Fusobacterium nucleatum subsp. nucleatum GN=kptA PE=3 SV=1
KPTA_FUSNN - Probable RNA 2'-phosphotransferase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / ...
9.0E-54 [11..199] [4..178]
KPTA_CLOPE - Probable RNA 2'-phosphotransferase OS=Clostridium perfringens GN=kptA PE=3 SV=1
gi|168213341, gi... - gi|170715146|gb|EDT27328.1| RNA 2'-phosphotransferase [Clostridium perfringens CPE str. F4969], gi|1...
KPTA_CLOPE - Probable RNA 2'-phosphotransferase OS=Clostridium perfringens (strain 13 / Type A) GN=kptA PE=3 SV=1
2.0E-53 [11..201] [5..180]

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Predicted Domain #1
Region A:
Residues: [1-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRQVLQKDKR DVQLSKALSY LLRHTAVKEK LTIDSNGYTP LKELLSHNRL KTHKCTVDDI  60
   61 HRIVKENDKQ RFHIKTLGAD EEWICATQGH SIKSIQPSDE VLVPITEASQ LPQELIHGTN 120
  121 LQSVIKIIES GAISPMSRNH VHLSPGMLHA KGVISGMRSS SNVYIFIDCH SPLFFQTLKM 180
  181 FRSLNNVYLS SSIPVELIQK VVVKGNLKDE EKLDTLRRIL HERNIPLEKI 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 31.008774
Match: PF01885
Description: RNA 2'-phosphotransferase, Tpt1 / KptA family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transferase activity, transferring pentosyl groups 3.32684164956045 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 3.05863250787371 bayes_pls_golite062009
NAD+ ADP-ribosyltransferase activity 2.37948308090148 bayes_pls_golite062009
binding 1.5526011325617 bayes_pls_golite062009
transferase activity 1.5222353301058 bayes_pls_golite062009
DNA binding 1.26521338734397 bayes_pls_golite062009
nucleic acid binding 1.22968208666588 bayes_pls_golite062009
catalytic activity 0.886617552734979 bayes_pls_golite062009
protein binding 0.847020402509418 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle