Protein Overview: SEC12

General Information:
Name(s) found:	SEC12 / YNR026C [SGD]
Description(s) found: Found 28 descriptions. SHOW ALL	Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER [SGD]
Organism:	Saccharomyces cerevisiae
Length:	471 amino acids
Gene Ontology:
Cellular Component:	integral to endoplasmic reticulum membrane [IDA] integral to membrane of membrane fraction [IDA]
Biological Process:	ER to Golgi vesicle-mediated transport [IDA] ER-associated protein catabolic process [IMP]
Molecular Function:	guanyl-nucleotide exchange factor activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFVTASYNV GYPAYGAKFL NNDTLLVAGG GGEGNNGIPN KLTVLRVDPT KDTEKEQFHI  60
   61 LSEFALEDND DSPTAIDASK GIILVGCNEN STKITQGKGN KHLRKFKYDK VNDQLEFLTS 120
  121 VDFDASTNAD DYTKLVYISR EGTVAAIASS KVPAIMRIID PSDLTEKFEI ETRGEVKDLH 180
  181 FSTDGKVVAY ITGSSLEVIS TVTGSCIARK TDFDKNWSLS KINFIADDTV LIAASLKKGK 240
  241 GIVLTKISIK SGNTSVLRSK QVTNRFKGIT SMDVDMKGEL AVLASNDNSI ALVKLKDLSM 300
  301 SKIFKQAHSF AITEVTISPD STYVASVSAA NTIHIIKLPL NYANYTSMKQ KISKFFTNFI 360
  361 LIVLLSYILQ FSYKHNLHSM LFNYAKDNFL TKRDTISSPY VVDEDLHQTT LFGNHGTKTS 420
  421 VPSVDSIKVH GVHETSSVNG TEVLCTESNI INTGGAEFEI TNATFREIDD A

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		SBH1 SEC12 SOP4 YOS1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	SEC12	Huh WK, et al. (2003)

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
protein binding	1.61720914342874	bayes_pls_golite062009
binding	1.40353148474598	bayes_pls_golite062009
transporter activity	1.21549336905926	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.949459052802047	bayes_pls_golite062009
small conjugating protein ligase activity	0.876326238093745	bayes_pls_golite062009
substrate-specific transporter activity	0.734793983890004	bayes_pls_golite062009
protein transporter activity	0.304681243699511	bayes_pls_golite062009
nucleic acid binding	0.110806113669931	bayes_pls_golite062009
acid-amino acid ligase activity	0.0294947647335083	bayes_pls_golite062009
hydrolase activity	0.0078918747815433	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.51

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..337]	PSI-BLAST	68.154902	beta1-subunit of the signal-transducing G protein heterotrimer
2	View Details	[338..471]	PSI-BLAST	26.30103	Groucho/tle1, C-terminal domain

Protein Overview: SEC12

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: