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Protein Overview: RNH201

General Information:
Name(s) found: RNH201 / YNL072W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; homolog of RNAse HI (the S. cerevisiae homolog of mammalian RNAse HII is RNH1); related to human AGS4 that causes Aicardi-Goutieres syndrome [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 307 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    ribonuclease H2 complex [IDALink to PubMed article]
    Biological Process: DNA replication [TASLink to PubMed article]
    Molecular Function: ribonuclease H activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVPPTVEASL ESPYTKSYFS PVPSALLEQN DSPIIMGIDE AGRGPVLGPM VYAVAYSTQK  60
   61 YQDETIIPNY EFDDSKKLTD PIRRMLFSKI YQDNEELTQI GYATTCITPL DISRGMSKFP 120
  121 PTRNYNLNEQ AHDVTMALID GVIKQNVKLS HVYVDTVGPP ASYQKKLEQR FPGVKFTVAK 180
  181 KADSLYCMVS VASVVAKVTR DILVESLKRD PDEILGSGYP SDPKTVAWLK RNQTSLMGWP 240
  241 ANMVRFSWQT CQTLLDDASK NSIPIKWEEQ YMDSRKNAAQ KTKQLQLQMV AKPVRRKRLR 300
  301 TLDNWYR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RNH201 RNH202
    View Details Krogan NJ, et al. (2006) RNH201 RNH202 RNH203
    View Details Qiu et al. (2008) RNH201 RNH202 RNH203

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RNH201 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..205] PSI-BLAST 234.70927 Class II ribonuclease H (RNase HII)
    2 View Details [206..307] PSI-BLAST 234.70927 Class II ribonuclease H (RNase HII)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ribonuclease H activity
    		•  8.30690368719529 bayes_pls_golite062009
  • ribonuclease activity
    		•  4.81599779544001 bayes_pls_golite062009
  • exoribonuclease activity
    		•  3.01417328311605 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  2.89077854960958 bayes_pls_golite062009
  • exonuclease activity
    		•  2.86892175148145 bayes_pls_golite062009
  • nuclease activity
    		•  2.84202779131927 bayes_pls_golite062009
  • hydrolase activity
    		•  2.78602644579272 bayes_pls_golite062009
  • DNA polymerase activity
    		•  2.75375255857158 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  2.66279543366449 bayes_pls_golite062009
  • endonuclease activity
    		•  2.63074055051349 bayes_pls_golite062009
  • endoribonuclease activity
    		•  2.59247838057313 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.57498413015114 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  2.49957333962564 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.94077739152313 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.87431870698721 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.12401205867904 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.12235348738959 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.10433412699603 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.86862629020506 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.782108781904855 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.77421125364834 bayes_pls_golite062009
  • binding
    		•  0.762139256580538 bayes_pls_golite062009
  • DNA binding
    		•  0.710663468386339 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.708753843279937 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.598360955770972 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • transcription factor activity
    		•  0.332903382446869 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle