Protein Overview: SPO1

General Information:
Name(s) found:	SPO1 / YNL012W [SGD]
Description(s) found: Found 22 descriptions. SHOW ALL	Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B [SGD]
Organism:	Saccharomyces cerevisiae
Length:	631 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] endoplasmic reticulum [IDA]
Biological Process:	meiosis [IMP]
Molecular Function:	phospholipase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKLLFVFSV LLTVVLATAP FQVQCPSSPL IREAKHELCP EETLYLKKKK IKTKNKLIQF  60
   61 LKSLTEAKFS SKFYKRVLKD PPKIGIAISG GGYRSMLVGT GFISQMNDYG LFEYSDYIAG 120
  121 LSGGSWILMD LVVQNFEVKS LLQEWDLEED LLLGIPEFDI SEEEIVTNAK KEYNDNDLKM 180
  181 KKRQGGSLIT SSSNFYEQIE EIMNSIEEIP EDYMITKRNL NPLARLKKIF FPNNTFTGTD 240
  241 AKIETFKKVL DFYKSLHLKI KPKKMEGFQI SFTDYWGKAI VQRLKKNFDD DPNHSFSFSK 300
  301 LVNSSKKFKE CSVPIPIFVA NCKNGLLSNV IFEFTPFEFG SWENILRLFV KLPYLGSKIV 360
  361 SGKAEKCINN FDDLGFITAT SSSIFNNVLI FIWNLASQSS REAMKALNMV MGIFGLGKEE 420
  421 IFSISKDSSR LETDYAVYQP NPFYLYPEKD NVLTNKNHLY LVDGGEDGEN IPLRTLVIPE 480
  481 RELDVIFVLD SSSDIDNYPN GSKLKRIFEK LDEENVHYQF PNNVKTFTHP IVIGCNATKR 540
  541 TGHDSFLPII IYHANANHGN ASNTSTFKIT YNQSEVSSML PTGRGVFSND YDLYYKNCLG 600
  601 CILTKRTMDR LPRKKKFSPF CLQCFKDYCY S

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SPO1	DDR2	2	Unpublished Fields Lab Data
View Screen	SPO1	SPO23	2	Uetz P, et al. (2000)
View Screen	SPT21	SPO1	1	Unpublished Fields Lab Data
View Screen	SPO1	RPA14	1	Unpublished Fields Lab Data
View Screen	SPO1	HSP104	1	Unpublished Fields Lab Data
View Screen	SPO1	VPS8	1	Unpublished Fields Lab Data
View Screen	SPO1	ATC1	1	Unpublished Fields Lab Data
View Screen	SPO1	TPO1	1	Unpublished Fields Lab Data
View Screen	SPO1	MED7	1	Unpublished Fields Lab Data
View Screen	SPO1	AKL1	1	Unpublished Fields Lab Data
View Screen	SPO1	SWA2	1	Unpublished Fields Lab Data
View Screen	SPO1	CFT2	1	Unpublished Fields Lab Data
View Screen	SPO1	KTR1	1	Unpublished Fields Lab Data
View Screen	SPO1	MIS1	1	Unpublished Fields Lab Data
View Screen	SPO1	STE14	1	Unpublished Fields Lab Data
View Screen	SPO1	YLR179C	1	Unpublished Fields Lab Data
View Screen	SPO1	SFL1	1	Unpublished Fields Lab Data
View Screen	SPO1	MUD1	1	Unpublished Fields Lab Data
View Screen	SPO1	TSA2	1	Unpublished Fields Lab Data
View Screen	SPO1	ENT2	1	Unpublished Fields Lab Data
View Screen	SPO1	ODC2	1	Unpublished Fields Lab Data
View Screen	SPO1	YBR138C	1	Unpublished Fields Lab Data
View Screen	SPO1	RTT105	1	Unpublished Fields Lab Data
View Screen	SPO1	YLR282C	1	Unpublished Fields Lab Data
View Screen	SPO1	RIM20	1	Unpublished Fields Lab Data
View Screen	SPO1	RPB5	1	Unpublished Fields Lab Data
View Screen	SPO1	SLX9	1	Unpublished Fields Lab Data
View Screen	SPO1	REH1	1	Unpublished Fields Lab Data
View Screen	SPO1	YOR392W	1	Unpublished Fields Lab Data
View Screen	SPO1	UMP1	1	Unpublished Fields Lab Data
View Screen	SPO1	PRP31	1	Unpublished Fields Lab Data
View Screen	SPO1	ORC1	1	Unpublished Fields Lab Data
View Screen	SPO1	YPL066W	1	Unpublished Fields Lab Data
View Screen	SPO1	PPE1	1	Unpublished Fields Lab Data
View Screen	SPO1	URA5	1	Unpublished Fields Lab Data
View Screen	SPO1	CDC60	1	Unpublished Fields Lab Data
View Screen	SPO1	YCR061W	1	Unpublished Fields Lab Data
View Screen	SPO1	AXL2	1	Unpublished Fields Lab Data
View Screen	SPO1	YMR262W	1	Unpublished Fields Lab Data
View Screen	SPO1	GRE1	1	Unpublished Fields Lab Data
View Screen	SPO1	MCD1	1	Unpublished Fields Lab Data
View Screen	SPO1	MHP1	1	Unpublished Fields Lab Data
View Screen	SPO1	YMR294W-A	1	Unpublished Fields Lab Data
View Screen	SPO1	PRE2	1	Unpublished Fields Lab Data
View Screen	SPO1	RPN5	1	Unpublished Fields Lab Data
View Screen	SPO1	UBX6	1	Unpublished Fields Lab Data
View Screen	SPO1	TEP1	1	Unpublished Fields Lab Data
View Screen	SPO1	DLD1	1	Unpublished Fields Lab Data
View Screen	SPO1	ASG7	1	Unpublished Fields Lab Data
View Screen	SPO1	ALF1	1	Unpublished Fields Lab Data
View Screen	SPO1	AAD4	1	Unpublished Fields Lab Data
View Screen	SPO1	ACF4	1	Unpublished Fields Lab Data
View Screen	SPO1	RAP1	1	Unpublished Fields Lab Data
View Screen	CDC53	SPO1	1	Unpublished Fields Lab Data
View Screen	SPO1	DAS2	1	Unpublished Fields Lab Data
View Screen	SPO1	STB6	1	Unpublished Fields Lab Data
View Screen	SPO1	MID1	1	Unpublished Fields Lab Data
View Screen	GND2	SPO1	1	Unpublished Fields Lab Data
View Screen	SPO1	MTQ2	1	Unpublished Fields Lab Data
View Screen	SPO1	KNS1	1	Unpublished Fields Lab Data
View Screen	SPO1	HOL1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..631]	PSI-BLAST	93.522879	Domain from cytosolic phospholipase A2; Cytosolic phospholipase A2 catalytic domain
2	View Details	[563..631]	FFAS03	1.74	Domain from cytosolic phospholipase A2; Cytosolic phospholipase A2 catalytic domain

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2