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Protein Overview: URA5

General Information:
Name(s) found: URA5 / YML106W [SGD]
Description(s) found:
Found 38 descriptions.
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  • Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 226 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: 'de novo' pyrimidine base biosynthetic process [TASLink to PubMed article]
    Molecular Function: orotate phosphoribosyltransferase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIMLEDYQK NFLELAIECQ ALRFGSFKLK SGRESPYFFN LGLFNTGKLL SNLATAYAIA  60
   61 IIQSDLKFDV IFGPAYKGIP LAAIVCVKLA EIGGSKFQNI QYAFNRKEAK DHGEGGIIVG 120
  121 SALENKRILI IDDVMTAGTA INEAFEIISN AKGQVVGSII ALDRQEVVST DDKEGLSATQ 180
  181 TVSKKYGIPV LSIVSLIHII TYLEGRITAE EKSKIEQYLQ TYGASA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) TGL2 URA10 URA5
    View Details Qiu et al. (2008) APT1 URA5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data URA5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..226] PSI-BLAST 558.221849 Orotate PRTase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • adenine phosphoribosyltransferase activity
    		•  3.1748712918814 bayes_pls_golite062009
  • uracil phosphoribosyltransferase activity
    		•  3.0470646511978 bayes_pls_golite062009
  • hypoxanthine phosphoribosyltransferase activity
    		•  2.97347277288245 bayes_pls_golite062009
  • transferase activity
    		•  2.73727660668741 bayes_pls_golite062009
  • transferase activity, transferring pentosyl groups
    		•  2.53679639481311 bayes_pls_golite062009
  • catalytic activity
    		•  2.30431811394775 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.21367942706564 bayes_pls_golite062009
  • orotate phosphoribosyltransferase activity
    		•  2.02298774328915 bayes_pls_golite062009
  • ribose phosphate diphosphokinase activity
    		•  1.51875493459374 bayes_pls_golite062009
  • nucleobase binding
    		•  1.28671115202467 bayes_pls_golite062009
  • purine binding
    		•  1.24786927434743 bayes_pls_golite062009
  • amidophosphoribosyltransferase activity
    		•  0.932396739123353 bayes_pls_golite062009
  • diphosphotransferase activity
    		•  0.749909396904601 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.552133387792911 bayes_pls_golite062009
  • binding
    		•  0.535390228935555 bayes_pls_golite062009
  • DNA binding
    		•  0.439741935655503 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.396538943915776 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle