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Protein Overview: ESC1

General Information:
Name(s) found: ESC1 / YMR219W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1658 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: chromatin silencing at telomere [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKKKETFTP RANKLKLTTP RRKLKILSSL LDADEDSKMK DQHGYSRVHN DKYRVAKPTQ  60
   61 HSTLHESISS RRSSHIHNKS LHEDSARALS WVDSLINRGK SILTTLEKED ALFERSLEEE 120
  121 RQRFQLHDSL MNKYTGNSKS HQRLIDLRKS QYGTDTSFQN NDEIPLDSFI SSPLPDAEDE 180
  181 SSSNIDSDKD EDLEGKQSLI KDFDLENDEY ELSEEEKNSD GQSSPSIMIL SDEEYAEEGA 240
  241 LQDVSNDEYA EEEGQVERKN IGQEQANVEN ATQISSSDSS EGQNYSEGVE MELEDDIDVE 300
  301 SDAEKDESQG AEGTEHSVDF SKYMQPRTDN TKIPVIEKYE SDEHKVHQRY SEDGAFDFGS 360
  361 VNISVDDESE DEESQAESYS ANAENVYHHN EHELDDKELI EDIESSDSES QSAQESEQGS 420
  421 EDDFEYKMKN EKSTSEETEN TSESRDQGFA KDAYTKNKVE QQENDEEPEK DDIIRSSLDK 480
  481 NFHGNNNKSE YSENVLENET DPAIVERENQ INDVEGYDVT GKSVESDLHE HSPDNLYDLA 540
  541 ARAMLQFQQS RNSNCPQKEE QVSESYLGHS NGSNLSGRSL DESEEQIPLK DFTGENNNNL 600
  601 KTDRGDLSSS VEIEVEKVSE KKLDGSTEKE LVPLSTDTTI NNSSLGNEDS IYYSLDDADA 660
  661 ISENLTDVPL MEIKTTPKYE VVISESVYSS TSYEDNTVAM PPQVEYTSPF MNDPFNSLND 720
  721 DYEKKHDLLK STLAALAPAF TKKDAEFVEA GVTKSCLTST SGHTNIFHTS KETKQVSDLD 780
  781 ESTENVTFEN ENTGDENKNQ SKNFPGVANS TDKSTEDNTD EKYFSAINYT NVTGDSSCED 840
  841 IIETASNVEE NLRYCEKDMN EAEMSSGDEC VKQNDDGSKT QISFSTDSPD NFQESNDNTE 900
  901 FSSTKYKVRN SDLEDDESLK KELTKAEVVD KLDEEESEDS YEQDYADPEP GNDEGSNENI 960
  961 VKGTKKDTLG IVEPENEKVN KVHEEETLFE ANVSSSVNVQ NKDMHTDVIN QEAQANYEAG1020
 1021 ERKYYIQNTD TEEAHISIIE RIDENAIGNN MEIPERSCVE KTHNEVLFER RATTIENTKA1080
 1081 LENNTNMHDQ VSQACSDSDR DQDSTAEKNV EGSAKHNLDI RVSSSEIESV EPLKPESDRS1140
 1141 NIFSSPIRVI GAVVKGVGKV VDVAESFVKK IDVMDSESDD NVDIGDYNQD IFNKSNSTDA1200
 1201 SVNMKSVSSK ERDSDEDEAV ILGGVTAEAH NDNGNNSRVI NIDPTTNGAY EEDSEVFRQQ1260
 1261 VKDKENLHKS EEPLVEGLQS EQHFEKKDHS ENEEEFDTIY GDITSANIHS NAPDDIKRQQ1320
 1321 LLKNLSDLEN YSQRLIEDSR RGKNQEESDE VNTSRERDLT FEKSVNEKYA GAIEEDTFSE1380
 1381 LDISIQHPEH EEDLDLSNNQ ERSIEELNSE PEEAELYELE IEGPTETAAS SKMNDDERQR1440
 1441 GNIPSTDLPS DPPSDKEEVT DSYPYSNSEN ITAEKSAPTS PEVYEIFSDT PNEVPMEIND1500
 1501 EIPATTLEKH DKTNVTSVLD DRSEHLSSHD VDNEPHDNSI NIKVNEGEEP EHQAVDIPVK1560
 1561 VEVKEEQEEM PSKSVLEEQK PSMELINDKS SPENNNDEET NREKDKTKAK KKSRKRNYNS1620
 1621 RRRKRKITEG SSAASNTKRR RGHEPKSRGQ NTHPSVDK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ESC1 ROX1 TAF2 TAF8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ESC1 Huh WK, et al. (2003)
    View Data ESC1 and NIC96 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [73..155] PSI-BLAST 7.0 Tropomyosin
    3 View Details [156..498] PSI-BLAST 19.221849 Heavy meromyosin subfragment
    4 View Details [499..571] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [572..629] PSI-BLAST 7.30103 Tropomyosin
    6 View Details [630..711] PSI-BLAST 7.30103 Tropomyosin
    7 View Details [712..773] PSI-BLAST 7.30103 Tropomyosin
    8 View Details [774..856] PSI-BLAST 7.30103 Tropomyosin
    9 View Details [857..1197] MSA 11.827997 View MSA. No confident structure predictions are available.
    10 View Details [1198..1273] deduced N/A No confident structure predictions are available.
    11 View Details [1274..1342] ORFEUS 14.86 No description for 1l8mA was found.
    12 View Details [1343..1658] ORFEUS 9.71 Sec24


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

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