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View Structure Prediction Details

Protein: ESC1
Organism: Saccharomyces cerevisiae
Length: 1658 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ESC1.

Description E-value Query
Range
Subject
Range
MYH2_PIG - Myosin-2 OS=Sus scrofa GN=MYH2 PE=2 SV=1
gi|55741490 - ref|NP_999301.1| myosin heavy chain 2a [Sus scrofa]
0.0 [94..1172] [848..1930]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
0.0 [94..1172] [849..1931]
gi|9800488, gi|1... - gi|9800488|gb|AAF99315.1|AF272034_1 fast myosin heavy chain isoform 3 [Gallus gallus], gi|165973976|...
0.0 [94..1182] [849..1941]
MYH1 - myosin, heavy chain 1, skeletal muscle, adult
0.0 [94..1172] [848..1930]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [94..1172] [849..1931]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
0.0 [94..1172] [847..1929]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKKKETFTP RANKLKLTTP RRKLKILSSL LDADEDSKMK DQHGYSRVHN DKYRVAKPTQ  60
   61 HSTLHESISS RR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.551 0.977 chromatin silencing at telomere a.4.1 Homeodomain-like

Predicted Domain #2
Region A:
Residues: [73-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSHIHNKSLH EDSARALSWV DSLINRGKSI LTTLEKEDAL FERSLEEERQ RFQLHDSLMN  60
   61 KYTGNSKSHQ RLIDLRKSQY GTD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [156-498]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSFQNNDEIP LDSFISSPLP DAEDESSSNI DSDKDEDLEG KQSLIKDFDL ENDEYELSEE  60
   61 EKNSDGQSSP SIMILSDEEY AEEGALQDVS NDEYAEEEGQ VERKNIGQEQ ANVENATQIS 120
  121 SSDSSEGQNY SEGVEMELED DIDVESDAEK DESQGAEGTE HSVDFSKYMQ PRTDNTKIPV 180
  181 IEKYESDEHK VHQRYSEDGA FDFGSVNISV DDESEDEESQ AESYSANAEN VYHHNEHELD 240
  241 DKELIEDIES SDSESQSAQE SEQGSEDDFE YKMKNEKSTS EETENTSESR DQGFAKDAYT 300
  301 KNKVEQQEND EEPEKDDIIR SSLDKNFHGN NNKSEYSENV LEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.221849
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [499-571]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETDPAIVERE NQINDVEGYD VTGKSVESDL HEHSPDNLYD LAARAMLQFQ QSRNSNCPQK  60
   61 EEQVSESYLG HSN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.706 0.962 chromatin silencing at telomere a.4.1 Homeodomain-like

Predicted Domain #5
Region A:
Residues: [572-629]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSNLSGRSLD ESEEQIPLKD FTGENNNNLK TDRGDLSSSV EIEVEKVSEK KLDGSTEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.30103
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [630-711]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELVPLSTDTT INNSSLGNED SIYYSLDDAD AISENLTDVP LMEIKTTPKY EVVISESVYS  60
   61 STSYEDNTVA MPPQVEYTSP FM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.30103
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [712-773]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDPFNSLNDD YEKKHDLLKS TLAALAPAFT KKDAEFVEAG VTKSCLTSTS GHTNIFHTSK  60
   61 ET

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.30103
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [774-856]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQVSDLDEST ENVTFENENT GDENKNQSKN FPGVANSTDK STEDNTDEKY FSAINYTNVT  60
   61 GDSSCEDIIE TASNVEENLR YCE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.30103
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [857-1197]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDMNEAEMSS GDECVKQNDD GSKTQISFST DSPDNFQESN DNTEFSSTKY KVRNSDLEDD  60
   61 ESLKKELTKA EVVDKLDEEE SEDSYEQDYA DPEPGNDEGS NENIVKGTKK DTLGIVEPEN 120
  121 EKVNKVHEEE TLFEANVSSS VNVQNKDMHT DVINQEAQAN YEAGERKYYI QNTDTEEAHI 180
  181 SIIERIDENA IGNNMEIPER SCVEKTHNEV LFERRATTIE NTKALENNTN MHDQVSQACS 240
  241 DSDRDQDSTA EKNVEGSAKH NLDIRVSSSE IESVEPLKPE SDRSNIFSSP IRVIGAVVKG 300
  301 VGKVVDVAES FVKKIDVMDS ESDDNVDIGD YNQDIFNKSN S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1198-1273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDASVNMKSV SSKERDSDED EAVILGGVTA EAHNDNGNNS RVINIDPTTN GAYEEDSEVF  60
   61 RQQVKDKENL HKSEEP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1274-1342]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVEGLQSEQH FEKKDHSENE EEFDTIYGDI TSANIHSNAP DDIKRQQLLK NLSDLENYSQ  60
   61 RLIEDSRRG

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.86
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #12
Region A:
Residues: [1343-1658]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNQEESDEVN TSRERDLTFE KSVNEKYAGA IEEDTFSELD ISIQHPEHEE DLDLSNNQER  60
   61 SIEELNSEPE EAELYELEIE GPTETAASSK MNDDERQRGN IPSTDLPSDP PSDKEEVTDS 120
  121 YPYSNSENIT AEKSAPTSPE VYEIFSDTPN EVPMEINDEI PATTLEKHDK TNVTSVLDDR 180
  181 SEHLSSHDVD NEPHDNSINI KVNEGEEPEH QAVDIPVKVE VKEEQEEMPS KSVLEEQKPS 240
  241 MELINDKSSP ENNNDEETNR EKDKTKAKKK SRKRNYNSRR RKRKITEGSS AASNTKRRRG 300
  301 HEPKSRGQNT HPSVDK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.71
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle