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Protein Overview: YCS4

General Information:
Name(s) found: YCS4 / YLR272C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1176 amino acids

    Gene Ontology:
    Cellular Component: nuclear condensin complex [IPILink to PubMed article][TASLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: meiotic chromosome condensation [IMPLink to PubMed article]
    mitotic chromosome condensation [IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article][TASLink to PubMed article]
    mitotic sister chromatid segregation [IMPLink to PubMed articleLink to PubMed article]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    maintenance of rDNA [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGFSLSEYL TKFQTTDRES YPRLQDPSRE LNVIIDQLAV SPEQIDASPD SLEALIDLCH  60
   61 DFPHLTPKLQ TQLSYLISSS LSNLSKDIKA NLSSNVNFTE IGGLIPQWKR HLEEYGYLIQ 120
  121 VLLTFLQDEL HKVSSQSTNL NRSAKNSKND SANVELFKRD CNQMENLLES ITKLLEINLS 180
  181 KIFQTTPEKD LFIGLFTRPL FVLLEIEPVT KVSSLKMFIQ RILAMCVKNH GQSSSIQSSL 240
  241 MTNLTYFLHL SVFNAELLKL LNDEYNYPQL TEDILKEIST RVFNAKDTTG PKAISNFLIK 300
  301 LSELSPGIML RQMNLVITLL NNSSITLRCS VVEACGNIVA ELAQDPQTME HYKQQIAVLI 360
  361 ELLEERFQDS NPYVRTKAIQ GCSKICDLSS KFNKSKAKFT SLAVRSLQDR SSLVRRNSVK 420
  421 LLSKLLLKHP FKAIHGSQLR LSEWEEYLKG SESQLNSTLK KVESQETLND TIERSLIEEE 480
  481 VEQDEGQCRT ELEGSFNKSA ELSRIENEVE NINATNTSVL MKLKLMIVYY KDAISFIKEI 540
  541 HKSIELISNL LFSKNRNEVL ESMDFLVLAD AFDIELSEFG IKKMLHLVWM KGTNDEGTSI 600
  601 SVHLIECYKQ LFLTAPDSCN MQEKAAHIAK NLINLSIGAS IADLASLEQL LGMMYEQKLI 660
  661 DQHVINILWA IYNSASKASM QKEQNVNNRD SEKGFSKEQI HGSIIILGML SLADNEIALK 720
  721 GLESLLNIGL GAVGLKDLTL CRYSCLALER MVPKRSTIIT KAINQELEDV AVKKLYAIII 780
  781 NYTKDNEYYP MCEQALSALF TISSKPDILA TDLIREKTMM TFGKPEEEDS ILSLEQSSRV 840
  841 VSLSQLLFIV GQVAIKTLVY LEKCEAEFKK RKIEAETRNG KVKNQGADVT NTTQDNGGDK 900
  901 ELEMIGGTNE DDFTDAIQFV KENELLFGEK SILGKFCPIV EEIVSNSSRF SDPMLQRTAT 960
  961 LCLEKLMCLS SKYCEKSLPL LITVMEKSPD PTIRSNAVLG LGDMAVCFNN LVDENTDYLY1020
 1021 RRLHDENLMV QRTCLMTVTF LILAGQVKVK GQLGEMAKCL DNPDQGISDM CRLFFTELAS1080
 1081 KDNAIYNGFI DIFSNLSSDD LLGKESFKKI IKFLLTFIDK ERHQKQLNEK LVGRLRKCET1140
 1141 QKQWDDIAFV LNNLPYKNED VTALLEQGFK VVSAKE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SMC2 YCS4
    View Details Krogan NJ, et al. (2006) BRN1 HIS2 SMC2 SMC4 YCG1 YCS4
    View Details Qiu et al. (2008) SMC2 SMC4 YCG1 YCS4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run RBA50 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YCS4 Huh WK, et al. (2003)
    View Data YCS4 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] ab initio 12.5 No description for 1ejlI was found.
    2 View Details [130..191] ab initio 12.5 No description for 1ejlI was found.
    3 View Details [192..253] ab initio 12.5 No description for 1ejlI was found.
    4 View Details [254..399] ab initio 14.05 No description for 1jpwA was found.
    5 View Details [400..526] ab initio 14.05 No description for 1jpwA was found.
    6 View Details [527..649] ab initio 14.05 No description for 1jpwA was found.
    7 View Details [650..703] ab initio 14.05 No description for 1jpwA was found.
    8 View Details [704..887] ab initio 14.05 No description for 1jpwA was found.
    9 View Details [888..945] deduced N/A No confident structure predictions are available.
    10 View Details [946..1176] PSI-BLAST 2.30103 Adaptin beta subunit N-terminal fragment


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle