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Protein Overview: RGT1

General Information:
Name(s) found: RGT1 / YKL038W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1170 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    Biological Process: negative regulation of transcription [IDALink to PubMed article]
    regulation of glucose import [IEPLink to PubMed article]
    glucose metabolic process [TASLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article][TASLink to PubMed article]
    RNA polymerase II transcription factor activity [TASLink to PubMed article]
    transcription corepressor activity [TASLink to PubMed article]
    transcription activator activity [TASLink to PubMed article]
    transcription repressor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNELNTVSTN SSDSTKNGGT SNSPDDMDSA AAASHAIKKR TKASRACDQC RKKKIKCDYK  60
   61 DEKGVCSNCQ RNGDRCSFDR VPLKRGPSKG YTRSTSHPRT NEIQDHNNSR SYNTFDNSNN 120
  121 TLNNNTGNSG DNGINSNTVP STPSRSNSVL LPPLTQYIPQ AGGIPPSFQN PAIQSTMPAG 180
  181 NIGQQQFWKV PYHEFQHQRK GSIDSLQSDI SVRTLNPNEQ LSYNTVQQSP ITNKHTNDSG 240
  241 NANGSVTGSG SASGSGGYWS FIRTSGLLAP TDDHNGEQTR RSSSIPSLLR NTSNSLLLGG 300
  301 QPQLPPPQQQ SQPQAHQQKL QQGQNLYSYS QFSQQQPYNP SISSFGQFAA NGFHSRQGSV 360
  361 ASEAMSPSAP AMFTSTSTNP VNVAQQTQRP QGQQVPQFSS ELDGNKRRQS APVSVTLSTD 420
  421 RLNGNENNNG EINNNNGSNN SGSSKDTSQH SQESVTTPAA LEASSPGSTP QRSTKKRRKS 480
  481 YVSKKTKPKR DSSISITSKD SAHPMTTSST IAYGQISDVD LIDTYYEFIH VGFPIIPLNK 540
  541 TTLTSDLLLV NTQPISNIHE VNSYVILWFR NSLELLVRVA LKQKPGGKFF DNIVGVALSP 600
  601 SNDNNKAGFT TATARDDAEK TRRDSHNEVQ DTLEVQSVFI AALNECFQKI VDIHPKFREN 660
  661 NDQISPKIKV IYLSTFILLN YILAFVGYDN SFVLGMSVTI FNEFKLYKLL LFPEPDINDV 720
  721 KPPVDEEVST GNGNTKTSEF EIGSESAGHM NPSNSPNSMD ENISHYSVLF KRLYVLLSVF 780
  781 DSLQSCAFGG PKLLNISIQG STERFFSNDL GSKWCLEQSQ LRLKSVLQSL KLGELMSELT 840
  841 RNRISMNGNR KPGFDITNSS SLLSEYVETQ PLSVAQLFCK LLIGKHNFIN CLLSLYDSEA 900
  901 GVYSDLTLDL SSKIADSLCS LISIILQVLT LILRLNPTNS IDFNYRPPNP PANNPTVQEG 960
  961 PSAMGSSPVA GNLSAAPPSE GNPDFYKKLL GLKQDTGTIL SDLCRGIISP FAIAILHEVY1020
 1021 NITELVKQMP TSLISIMMTA TTTQNTQDTK KSQDLVMKLS NSMNEVVQIT SVLTMIKPFK1080
 1081 IFEHELNKPI MSLTGGLSST TRNDVMWPKS GQGLRESSVM KTLLDERRTS GTQPTTAPVA1140
 1141 AEEPRLENVA LENFVSIGWK LLDDSELGWY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BIR1 sample bir 1 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RGT1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] PSI-BLAST 10.0 Hap1 (Cyp1); HAP1
    2 View Details [121..470] MSA 28.369997 View MSA. No confident structure predictions are available.
    3 View Details [471..1170] deduced N/A No confident structure predictions are available.
    4 View Details [458..602] deduced N/A No confident structure predictions are available.
    5 View Details [603..722] deduced N/A No confident structure predictions are available.
    6 View Details [723..976] deduced N/A No confident structure predictions are available.
    7 View Details [977..1170] MSA 1.005945 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.86871420827942 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.03201524223606 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.87955444697212 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.86200506906385 bayes_pls_golite062009
  • transcription activator activity
    		•  0.915626626047549 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle