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Protein Overview: BNA2

General Information:
Name(s) found: BNA2 / YJR078W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expresssion is upregulated upon telomere uncapping; regulated by Hst1p and Aft2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 453 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: NAD biosynthetic process [IMPLink to PubMed article]
    Molecular Function: tryptophan 2,3-dioxygenase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNTSITGPQ VLHRTKMRPL PVLEKYCISP HHGFLDDRLP LTRLSSKKYM KWEEIVADLP  60
   61 SLLQEDNKVR SVIDGLDVLD LDETILGDVR ELRRAYSILG FMAHAYIWAS GTPRDVLPEC 120
  121 IARPLLETAH ILGVPPLATY SSLVLWNFKV TDECKKTETG CLDLENITTI NTFTGTVDES 180
  181 WFYLVSVRFE KIGSACLNHG LQILRAIRSG DKGDANVIDG LEGLAATIER LSKALMEMEL 240
  241 KCEPNVFYFK IRPFLAGWTN MSHMGLPQGV RYGAEGQYRI FSGGSNAQSS LIQTLDILLG 300
  301 VKHTANAAHS SQGDSKINYL DEMKKYMPRE HREFLYHLES VCNIREYVSR NASNRALQEA 360
  361 YGRCISMLKI FRDNHIQIVT KYIILPSNSK QHGSNKPNVL SPIEPNTKAS GCLGHKVASS 420
  421 KTIGTGGTRL MPFLKQCRDE TVATADIKNE DKN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..453] Pfam 1000.0 Indoleamine 2,3-dioxygenase No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • tryptophan 2,3-dioxygenase activity
    		•  6.12572739599944 bayes_pls_golite062009
  • indoleamine 2,3-dioxygenase activity
    		•  5.36711489399682 bayes_pls_golite062009
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
    		•  5.10746429248081 bayes_pls_golite062009
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
    		•  5.0264927787349 bayes_pls_golite062009
  • dioxygenase activity
    		•  2.84465044204327 bayes_pls_golite062009
  • catalytic activity
    		•  1.41033217274476 bayes_pls_golite062009
  • binding
    		•  1.25607690618244 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.19120347286896 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle