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Protein Overview: GEA1

General Information:
Name(s) found: GEA1 / YJR031C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1408 amino acids

    Gene Ontology:
    Cellular Component: Golgi cis cisterna [IDALink to PubMed article]
    Golgi-associated vesicle [IPILink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IMPLink to PubMed article]
    retrograde vesicle-mediated transport, Golgi to ER [IGILink to PubMed article]
    intra-Golgi vesicle-mediated transport [IPILink to PubMed article]
    actin cytoskeleton organization [IGILink to PubMed article]
    Molecular Function: ARF guanyl-nucleotide exchange factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHDVPMETVL AVNPATMIVK ECINLCSAMN KQSRDKSQTS VAALLGGGSD IFLSQSDSFV  60
   61 DSFHNLPTSS YHDPLISGLV QLRLKINDLK GLDSLNALEL LKPFLEIVSA SSVSGYTTSL 120
  121 ALDSLQKVFT LKIINKTFND IQIAVRETVV ALTHCRFEAS KQISDDSVLL KVVTLLRDII 180
  181 TSSFGDYLSD TIIYDVLQTT LSLACNTQRS EVLRKTAEVT IAGITVKLFT KLKLLDPPTK 240
  241 TEKYINDESY TDNNLKDDII GTTTSDNDLS STDDDSAVAD DNKNEKPVQQ VIREQENDEE 300
  301 TAEKAENVEP NYGITVIKDY LGLLLSLVMP ENRMKHTTSA MKLSLQLINA AIEISGDKFP 360
  361 LYPRLFSLIS DPIFKSVLFI IQSSTQYSLL QATLQLFTSL VVILGDYLPM QIELTLRRIF 420
  421 EILEDTTISG DVSKQKPPAI RELIIEQLSI LWIHSPAFFL QLFVNFDCNL DRSDLSIDFI 480
  481 KELTKFSLPA AAVNTSNNIP PICLEGVLSL IENIYNDLQR FDRAEFVKNQ KEIDILKQRD 540
  541 RKTEFILCVE TFNEKAKKGI QMLIEKGFID SDSNRDIASF LFLNNGRLNK KTIGLLLCDP 600
  601 KKTSLLKEFI DLFDFKGLRV DEAIRILLTK FRLPGESQQI ERIVEAFSSK YSADQSNDKV 660
  661 ELEDKKAGKN GSESMTEDDI IHVQPDADSV FVLSYSIIML NTDSHNPQVK DHMTFDDYSN 720
  721 NLRGCYNGKD FPRWYLHKIY TSIKVKEIVM PEEHHGNERW FEDAWNNLIS STSVMTEMQR 780
  781 DFTNPISKLA QIDILQYEKA IFSNVRDIIL KTLFKIFTVA SSDQISLRIL DAISKCTFIN 840
  841 YYFSFDQSYN DTVLHLGEMT TLAQSSAKAV ELDVDSIPLV EIFVEDTGSK ISVSNQSIRL 900
  901 GQNFKAQLCT VLYFQIIKEI SDPSIVSTRL WNQIVQLILK LFENLLMEPN LPFFTNFHSL 960
  961 LKLPELPLPD PDISIRKAKM SRSLLSTFAS YLKGDEEPSE EDIDFSIKAF ECVKASHPLS1020
 1021 SVFENNQLVS PKMIETLLSS LVIEKTSENS PYFEQELLFL LEISIILISE ASYGQEFGAL1080
 1081 IADHMINISN LDGLSKEAIA RLASYKMFLV SRFDNPRDIL SDLIEHDFLV KNEIFNTKYY1140
 1141 ESEWGKQVIN DLFTHLNDVK YNERALKNVK FWNFLRILIS AKDRQFAVYT FLEKYIQNGD1200
 1201 IFVDDGNFMN ILSLLDEMSC AGAVGTKWEQ NYENSVEDGC EAPESNPYRS IIDLSSRSIN1260
 1261 ITADLLSTVG RSNSALNKNE IIAAIQGLAH QCLNPCDELG MQALQALENI LLSRASQLRT1320
 1321 EKVAVDNLLE TGLLPIFELD EIQDVKMKRI TSILSVLSKI FLGQLVEGVT SNETFLRVLN1380
 1381 VFNKYVDDPT VERQLQELII SKREIEKE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GEA1 UBP12
    View Details Qiu et al. (2008) GEA1 GEA2 GLO3 SEC7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GEA1 Huh WK, et al. (2003)
    View Data GEA1 and ANP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..521] MSA 2.04093 View MSA. No confident structure predictions are available.
    2 View Details [522..608] PSI-BLAST 918.154902 ARF guanine-exchange factor 2, Gea2
    3 View Details [609..758] PSI-BLAST 918.154902 ARF guanine-exchange factor 2, Gea2
    4 View Details [759..819] PSI-BLAST 3.39794 Grp1
    5 View Details [820..1048] ORFEUS 8.25 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    6 View Details [1049..1116] ORFEUS 8.25 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    7 View Details [1117..1408] ORFEUS 8.25 Constant regulatory domain of protein phosphatase 2a, pr65alpha

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • ARF guanyl-nucleotide exchange factor activity
    		•  6.57705646633597 bayes_pls_golite062009
  • GTPase regulator activity
    		•  3.37865780899325 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  3.23621073985922 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  3.11224105598265 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  2.75174745190211 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.95578809138334 bayes_pls_golite062009
  • binding
    		•  1.3334812784277 bayes_pls_golite062009
  • protein binding
    		•  0.917306986228715 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.909190013421997 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.0750646331148792 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0172309833091902 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle