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Protein Overview: DPB11

General Information:
Name(s) found: DPB11 / YJL090C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 764 amino acids

    Gene Ontology:
    Cellular Component: replication fork [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: DNA replication initiation [TASLink to PubMed article]
    DNA replication checkpoint [IMPLink to PubMed article]
    lagging strand elongation [TASLink to PubMed article]
    recombinational repair [IDALink to PubMed article][IGILink to PubMed article]
    leading strand elongation [TASLink to PubMed article]
    nucleotide-excision repair [TASLink to PubMed article]
    mismatch repair [NASLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPFQGITFC PTAINNEILA KKISKKIIKL GGIFSKDLTR QVNVLVVGST TNTNKFKFAV  60
   61 KHRFDIIFID IQAIDDIYQL WLSGENILPD SNTATMTGST YEMLKILYRR FSFKYLHNFN 120
  121 IFIGRITDTN ITSIDSLVRS IKKLGCSSYN YQNFVIKDTS SHNDDDDQGQ NGQISIFVTD 180
  181 TLLGARVNAA IEQNIPIVHF KWILDCQKRS ALLPYDPYYL LPNIKDLPYD SIGSNSCDCW 240
  241 DKINTTFPTN IDAQSSLQRQ QSSSTLTPSL PKTSSLLNKF KPKGEKIWDK AMSLQQHSKT 300
  301 NFSVLGQSPL SINNKQEDLS DNSTLIFKNC AFIIHHIFPG NHRSILTKIV VQNGGKIETS 360
  361 YLSGIYDHSY YIIPSNKALD SFNDLPEIID DNDGIVTEFF IERCLYYQKL LHPIDLWSKP 420
  421 FLSTIEFQVS SSSKLLHHEF SSSPFLNVTI TGFSGVELLH LTKVLNLLKP MGINYVEYLN 480
  481 KSTDILLINL AALPSIPKTH PLWSNEFSDL FTQFCINNNN DDPGDNNRKD FQNNSILRNS 540
  541 MKRKIEYIKK FHSIPVVTPA FIFKLLSAAS GENNEIFLNN IKWCIICPRG HKDDFKCKIK 600
  601 KPYYTSISSE KKYQNNDPKI DKTILLKRNN SSLSEHSMKD TKNELLQKIR ETDSGRKKRS 660
  661 VSSSIMDVSS ERQMPDTKRI KLESLPKNFV PKQIKRTTSW GTIMSENVPT EQPTAISNPE 720
  721 EIPRTEEVSH TQVTYGSIQD KKRTASLEKP MRRQTRNQTK ELDS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CDC45 CDC6 DPB11 DPB2 DPB3 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POL2 POL3 POL31 POL32 SLD3
    View Details Ho Y, et al. (2002) DPB11 NMD3 SRP1 TIF4631
    View Details Qiu et al. (2008) CDC45 DPB11 DPB2 DPB3 DPB4 ELG1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MRC1 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POL2 POL3 POL30 POL31 POL32 RFC1 RFC2 RFC4 SLD3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ELA1 DPB11 2 Unpublished Fields Lab Data
    View Screen SPO21 DPB11 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DPB11 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..124] ORFEUS 11.3 Breast cancer associated protein, BRCA1
    2 View Details [125..263] ORFEUS 11.3 Breast cancer associated protein, BRCA1
    3 View Details [264..320] deduced N/A No confident structure predictions are available.
    4 View Details [321..429] Pfam 8.522879 BRCA1 C Terminus (BRCT) domain No confident structure predictions are available.
    5 View Details [430..764] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle