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Protein Overview: PDR1

General Information:
Name(s) found: PDR1 / YGL013C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1068 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [TASLink to PubMed article]
    Molecular Function: DNA binding [IPILink to PubMed article]
    transcription activator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRGLTPKNGV HIETGPDTES SADSSNFSTG FSGKIRKPRS KVSKACDNCR KRKIKCNGKF  60
   61 PCASCEIYSC ECTFSTRQGG ARIKNLHKTS LEGTTVQVKE ETDSSSTSFS NPQRCTDGPC 120
  121 AVEQPTKFFE NFKLGGRSSG DNSGSDGKND DDVNRNGFYE DDSESQATLT SLQTTLKNLK 180
  181 EMAHLGTHVT SAIESIELQI SDLLKRWEPK VRTKELATTK FYPNKSIETQ LMKNKYCDVV 240
  241 HLTRYAAWSN NKKDQDTSSQ PLIDEIFGLY SPFQFLSLQG IGKCFQNYRS KSKCEIFPRT 300
  301 AKETIYIMLR FFDVCFHHIN QGCVSIANPL ENYLQKMNLL PSTPSSISSA GSPNTAHTKS 360
  361 HVALVINHLP QPFVRNITGI SNSELLSEMN NDISMFGILL KMLDMHKNSY QNFLMEITSN 420
  421 PSVAKNTQSI DVLQEFIHYC QAGEALIALC YSYYNSTLYN YVDFTCDITH LEQLLYFLDL 480
  481 LFWLSEIYGF EKVLNVAVHF VSRVGLSRWE FYVGLDENFA ERRRNLWWKA FYFEKTLASK 540
  541 LGYPSNIDDS KINCLLPKNF RDVGFLDNRD FIENVHLVRR SEAFDNMCIS DLKYYGELAV 600
  601 LQIVSHFSSS VLFNEKFTSI RNTSKPSVVR EKLLFEVLEI FNETEMKYDA IKEQTGKLFD 660
  661 IAFSKDSTEL KVSREDKIMA SKFVLFYEHH FCRMVNESDN IVARLCVHRR PSILIENLKI 720
  721 YLHKIYKSWT DMNKILLDFD NDYSVYRSFA HYSISCIILV SQAFSVAEFI KVNDVVNMIR 780
  781 VFKRFLDIKI FSENETNEHV FNSQSFKDYT RAFSFLTIVT RIMLLAYGES SSTNLDVISK 840
  841 YIDENAPDLK GIIELVLDTN SCAYRFLLEP VQKSGFHLTV SQMLKNRKFQ EPLMSNEDNK 900
  901 QMKHNSGKNL NPDLPSLKTG TSCLLNGIES PQLPFNGRSA PSPVRNNSLP EFAQLPSFRS 960
  961 LSVSDMINPD YAQPTNGQNN TQVQSNKPIN AQQQIPTSVQ VPFMNTNEIN NNNNNNNNNK1020
 1021 NNINNINNNN SNNFSATSFN LGTLDEFVNN GDLEDLYSIL WSDVYPDS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CRP1 IDS2 PDR1 PEP4 PRC1 RTN1 SIA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RRP17 PDR1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PDR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] PSI-BLAST 36.274545 Gal4; CD2-Gal4
    2 View Details [112..420] deduced N/A No confident structure predictions are available.
    3 View Details [421..574] MSA 3.012997 View MSA. No confident structure predictions are available.
    4 View Details [575..1068] deduced N/A No confident structure predictions are available.
    5 View Details [467..557] Pfam 17.420216 No description for PF04082.9 was found. No confident structure predictions are available.
    6 View Details [558..798] deduced N/A No confident structure predictions are available.
    7 View Details [799..1068] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.98081393153291 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.93914501897006 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.44382866473054 bayes_pls_golite062009
  • transcription activator activity
    		•  2.24483536326713 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle