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Protein Overview: COX15

General Information:
Name(s) found: COX15 / YER141W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 486 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: heme a biosynthetic process [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor [IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFRNIEVGR QAAKLLTRTS SRLAWQSIGA SRNISTIRQQ IRKTQLYNFK KTVSIRPFSL  60
   61 SSPVFKPHVA SESNPIESRL KTSKNVAYWL IGTSGLVFGI VVLGGLTRLT ESGLSITEWK 120
  121 PVTGTLPPMN QKEWEEEFIK YKESPEFKLL NSHIDLDEFK FIFFMEWIHR LWGRAIGAVF 180
  181 ILPAVYFAVS KKTSGHVNKR LFGLAGLLGL QGFVGWWMVK SGLDQEQLDA RKSKPTVSQY 240
  241 RLTTHLGTAF FLYMGMLWTG LEILRECKWI KNPVQAISLF KKLDNPAIGP MRKISLALLA 300
  301 VSFLTAMSGG MVAGLDAGWV YNTWPKMGER WFPSSRELMD ENFCRREDKK DLWWRNLLEN 360
  361 PVTVQLVHRT CAYVAFTSVL AAHMYAIKKK AVIPRNAMTS LHVMMGVVTL QATLGILTIL 420
  421 YLVPISLASI HQAGALALLT SSLVFASQLR KPRAPMRNVI ITLPHSSKVT SGKILSEASK 480
  481 LASKPL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) COX15 HEM15 YAH1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data COX15 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..64] deduced N/A No confident structure predictions are available.
    2 View Details [65..486] Pfam 232.136677 Cytochrome oxidase assembly protein No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquinol-cytochrome-c reductase activity
    		•  7.14310447988324 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
    		•  7.14310447988324 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  6.65042885188134 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  6.2348043478393 bayes_pls_golite062009
  • oxidoreductase activity
    		•  6.22065377967058 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  6.08945082672142 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  5.51765086641155 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.28889439153372 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.09706550560082 bayes_pls_golite062009
  • electron carrier activity
    		•  5.05484726071629 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.69386138862713 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.49686615631891 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  4.47868923048875 bayes_pls_golite062009
  • electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity
    		•  2.35477367604999 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  2.19856564436406 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  2.01252432296098 bayes_pls_golite062009
  • binding
    		•  1.19028351409325 bayes_pls_golite062009
  • catalytic activity
    		•  1.1157818338774 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.726462910735645 bayes_pls_golite062009
  • protein binding
    		•  0.291685656235254 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle