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View Structure Prediction Details

Protein: COX15
Organism: Saccharomyces cerevisiae
Length: 486 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COX15.

Description E-value Query
Range
Subject
Range
gi|190405700 - gi|190405700|gb|EDV08967.1| cytochrome oxidase assembly factor [Saccharomyces cerevisiae RM11-1a]
COX15_YEAST - Cytochrome c oxidase assembly protein COX15 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
gi|207345832 - gi|207345832|gb|EDZ72525.1| YER141Wp-like protein [Saccharomyces cerevisiae AWRI1631]
COX15 - Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic gr...
0.0 [1..486] [1..486]
etp1 - mitochondrial type I [2Fe-2S] ferredoxin Etp1 / cytochrome oxidase cofactor Cox15, fusion
gi|19115748 - gi|19115748|ref|NP_594836.1| mitochondrial type I [2Fe-2S] ferredoxin Etp1/ cytochrome oxidase cofac...
0.0 [16..459] [27..473]
gi|18204496 - gi|18204496|gb|AAH21498.1| Cox15 protein [Mus musculus]
0.0 [26..451] [13..413]
gi|3603230 - gi|3603230|gb|AAD08639.1| cytochrome oxidase assembly factor [Homo sapiens]
0.0 [50..451] [36..407]
COX15_ARATH - Cytochrome c oxidase assembly protein COX15 OS=Arabidopsis thaliana GN=COX15 PE=2 SV=1
0.0 [2..468] [9..453]
gi|60468533, gi|... - gi|60468533|gb|EAL66536.1| cytochrome c oxidase assembly protein [Dictyostelium discoideum], gi|3420...
gi|60468533, gi|... - gi|66812926|ref|XP_640642.1| cytochrome c oxidase assembly protein [Dictyostelium discoideum AX4], g...
0.0 [29..451] [53..479]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFRNIEVGR QAAKLLTRTS SRLAWQSIGA SRNISTIRQQ IRKTQLYNFK KTVSIRPFSL  60
   61 SSPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [65-486]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKPHVASESN PIESRLKTSK NVAYWLIGTS GLVFGIVVLG GLTRLTESGL SITEWKPVTG  60
   61 TLPPMNQKEW EEEFIKYKES PEFKLLNSHI DLDEFKFIFF MEWIHRLWGR AIGAVFILPA 120
  121 VYFAVSKKTS GHVNKRLFGL AGLLGLQGFV GWWMVKSGLD QEQLDARKSK PTVSQYRLTT 180
  181 HLGTAFFLYM GMLWTGLEIL RECKWIKNPV QAISLFKKLD NPAIGPMRKI SLALLAVSFL 240
  241 TAMSGGMVAG LDAGWVYNTW PKMGERWFPS SRELMDENFC RREDKKDLWW RNLLENPVTV 300
  301 QLVHRTCAYV AFTSVLAAHM YAIKKKAVIP RNAMTSLHVM MGVVTLQATL GILTILYLVP 360
  361 ISLASIHQAG ALALLTSSLV FASQLRKPRA PMRNVIITLP HSSKVTSGKI LSEASKLASK 420
  421 PL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 232.136677
Match: PF02628
Description: Cytochrome oxidase assembly protein

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
ubiquinol-cytochrome-c reductase activity 7.14310447988324 bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor 7.14310447988324 bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors 6.65042885188134 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 6.2348043478393 bayes_pls_golite062009
oxidoreductase activity 6.22065377967058 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 6.08945082672142 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 5.51765086641155 bayes_pls_golite062009
cation transmembrane transporter activity 5.28889439153372 bayes_pls_golite062009
ion transmembrane transporter activity 5.09706550560082 bayes_pls_golite062009
electron carrier activity 5.05484726071629 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.69386138862713 bayes_pls_golite062009
substrate-specific transporter activity 4.49686615631891 bayes_pls_golite062009
NADH dehydrogenase activity 4.47868923048875 bayes_pls_golite062009
electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity 2.35477367604999 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 2.19856564436406 bayes_pls_golite062009
formate dehydrogenase activity 2.01252432296098 bayes_pls_golite062009
binding 1.19028351409325 bayes_pls_golite062009
catalytic activity 1.1157818338774 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.726462910735645 bayes_pls_golite062009
protein binding 0.291685656235254 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle