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Protein Overview: CCC2

General Information:
Name(s) found: CCC2 / YDR270W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1004 amino acids

    Gene Ontology:
    Cellular Component: trans-Golgi network transport vesicle membrane [IDALink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IMPLink to PubMed article]
    intracellular copper ion transport [IMPLink to PubMed article]
    Molecular Function: cation-transporting ATPase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREVILAVHG MTCSACTNTI NTQLRALKGV TKCDISLVTN ECQVTYDNEV TADSIKEIIE  60
   61 DCGFDCEILR DSEITAISTK EGLLSVQGMT CGSCVSTVTK QVEGIEGVES VVVSLVTEEC 120
  121 HVIYEPSKTT LETAREMIED CGFDSNIIMD GNGNADMTEK TVILKVTKAF EDESPLILSS 180
  181 VSERFQFLLD LGVKSIEISD DMHTLTIKYC CNELGIRDLL RHLERTGYKF TVFSNLDNTT 240
  241 QLRLLSKEDE IRFWKKNSIK STLLAIICML LYMIVPMMWP TIVQDRIFPY KETSFVRGLF 300
  301 YRDILGVILA SYIQFSVGFY FYKAAWASLK HGSGTMDTLV CVSTTCAYTF SVFSLVHNMF 360
  361 HPSSTGKLPR IVFDTSIMII SYISIGKYLE TLAKSQTSTA LSKLIQLTPS VCSIISDVER 420
  421 NETKEIPIEL LQVNDIVEIK PGMKIPADGI ITRGESEIDE SLMTGESILV PKKTGFPVIA 480
  481 GSVNGPGHFY FRTTTVGEET KLANIIKVMK EAQLSKAPIQ GYADYLASIF VPGILILAVL 540
  541 TFFIWCFILN ISANPPVAFT ANTKADNFFI CLQTATSVVI VACPCALGLA TPTAIMVGTG 600
  601 VGAQNGVLIK GGEVLEKFNS ITTFVFDKTG TLTTGFMVVK KFLKDSNWVG NVDEDEVLAC 660
  661 IKATESISDH PVSKAIIRYC DGLNCNKALN AVVLESEYVL GKGIVSKCQV NGNTYDICIG 720
  721 NEALILEDAL KKSGFINSNV DQGNTVSYVS VNGHVFGLFE INDEVKHDSY ATVQYLQRNG 780
  781 YETYMITGDN NSAAKRVARE VGISFENVYS DVSPTGKCDL VKKIQDKEGN NKVAVVGDGI 840
  841 NDAPALALSD LGIAISTGTE IAIEAADIVI LCGNDLNTNS LRGLANAIDI SLKTFKRIKL 900
  901 NLFWALCYNI FMIPIAMGVL IPWGITLPPM LAGLAMAFSS VSVVLSSLML KKWTPPDIES 960
  961 HGISDFKSKF SIGNFWSRLF STRAIAGEQD IESQAGLMSN EEVL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARC1 ATG14 CAT8 CCC2 HEK2 IRC20 MCA1 MES1 MGA2 NCS2 NHA1 PET127 PHO89 PHO91 YKL050C YLR363W-A
    View Details Qiu et al. (2008) CCC2 DNF3 ENB1 PMR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CCC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..75] PSI-BLAST 350.68867 Copper transporter domain ccc2a
    2 View Details [76..163] PSI-BLAST 56.0 Potential copper-translocating P-type ATPase
    3 View Details [164..282] ORFEUS 11.46 Copper chaperone
    4 View Details [283..335] deduced N/A No confident structure predictions are available.
    5 View Details [336..409]
    [554..1004]    		 PSI-BLAST 221.9897 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
    6 View Details [410..553] PSI-BLAST 221.9897 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • copper chaperone activity
    		•  9.82063669832995 bayes_pls_golite062009
  • copper-dependent protein binding
    		•  9.4886676850819 bayes_pls_golite062009
  • metallochaperone activity
    		•  8.74818422646376 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  8.43432598400875 bayes_pls_golite062009
  • copper-exporting ATPase activity
    		•  8.28760545731379 bayes_pls_golite062009
  • copper-transporting ATPase activity
    		•  8.16711362928142 bayes_pls_golite062009
  • superoxide dismutase copper chaperone activity
    		•  7.67724993505658 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  7.20908701283122 bayes_pls_golite062009
  • copper ion binding
    		•  5.41725082570189 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  5.4007166857771 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.61622753861072 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.52484959112186 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.12792340516867 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  4.10264569844449 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  3.70964017127302 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  3.27250923701445 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  2.98847682261773 bayes_pls_golite062009
  • metal ion binding
    		•  2.69806984896689 bayes_pls_golite062009
  • cation binding
    		•  2.69806984896689 bayes_pls_golite062009
  • ion binding
    		•  2.69078950610234 bayes_pls_golite062009
  • transition metal ion binding
    		•  2.52520930681159 bayes_pls_golite062009
  • transporter activity
    		•  2.43435890488191 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.32163502360862 bayes_pls_golite062009
  • binding
    		•  2.31155280022787 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.28845421748925 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.62116507842838 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.61680623728503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  1.59572740343301 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  1.5925429451548 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  1.59219836319916 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.53883152283038 bayes_pls_golite062009
  • hydrolase activity
    		•  1.26149508477113 bayes_pls_golite062009
  • ATPase activity
    		•  1.12732384636594 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.1123150216263 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.04872000948037 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.03270166246194 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.02977205960797 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.02520458852568 bayes_pls_golite062009
  • protein binding
    		•  0.889287086236279 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.75722873989123 bayes_pls_golite062009
    2
    Term Confidence Notes
  • copper chaperone activity
    		•  9.82063669832995 bayes_pls_golite062009
  • copper-dependent protein binding
    		•  9.4886676850819 bayes_pls_golite062009
  • metallochaperone activity
    		•  8.74818422646376 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  8.43432598400875 bayes_pls_golite062009
  • copper-exporting ATPase activity
    		•  8.28760545731379 bayes_pls_golite062009
  • copper-transporting ATPase activity
    		•  8.16711362928142 bayes_pls_golite062009
  • superoxide dismutase copper chaperone activity
    		•  7.67724993505658 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  7.20908701283122 bayes_pls_golite062009
  • copper ion binding
    		•  5.41725082570189 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  5.4007166857771 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.61622753861072 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.52484959112186 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.12792340516867 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  4.10264569844449 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  3.70964017127302 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  3.27250923701445 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  2.98847682261773 bayes_pls_golite062009
  • metal ion binding
    		•  2.69806984896689 bayes_pls_golite062009
  • cation binding
    		•  2.69806984896689 bayes_pls_golite062009
  • ion binding
    		•  2.69078950610234 bayes_pls_golite062009
  • transition metal ion binding
    		•  2.52520930681159 bayes_pls_golite062009
  • transporter activity
    		•  2.43435890488191 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.32163502360862 bayes_pls_golite062009
  • binding
    		•  2.31155280022787 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.28845421748925 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.62116507842838 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.61680623728503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  1.59572740343301 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  1.5925429451548 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  1.59219836319916 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.53883152283038 bayes_pls_golite062009
  • hydrolase activity
    		•  1.26149508477113 bayes_pls_golite062009
  • ATPase activity
    		•  1.12732384636594 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.1123150216263 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.04872000948037 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.03270166246194 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.02977205960797 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.02520458852568 bayes_pls_golite062009
  • protein binding
    		•  0.889287086236279 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.75722873989123 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle