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Protein Overview: NBP2

General Information:
Name(s) found: NBP2 / YDR162C [SGD]
Description(s) found:
Found 34 descriptions.
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  • Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 236 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    cytoplasm [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: response to heat [IMPLink to PubMed article]
    negative regulation of protein kinase activity [IDALink to PubMed article]
    hyperosmotic response [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATMETTTQK DTNILKSGLK KTIGVLNEAV LQNGREVEAV QAGNSDTMED TETTTIGYIS  60
   61 IKDYAYADSN PLHYGYFDGD NEEDEMVSDS SNGEDTYNKR QSITLPDDYI VNQRAVALYD 120
  121 FEPENDNELR LAEGDIVFIS YKHGQGWLVA ENESGSKTGL VPEEFVSYIQ PEDGENEVEN 180
  181 KARPFYLTHL ITQSVSPKNN IDNTNEDEYD DNDEWEDIDD VAEVEADMKT KLDISD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) NBP2 PBS2 PTC1
    View Details Ho Y, et al. (2002) BIO3 NBP2 PBS2 PDA1 PTC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] deduced N/A No confident structure predictions are available.
    2 View Details [104..166] PSI-BLAST 45.0 Bruton's tyrosine kinase
    3 View Details [167..236] PSI-BLAST 10.09691 Tyrosine kinase Fyn

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • protein binding
    		•  2.14586566310919 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.38649262176488 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.28138694351561 bayes_pls_golite062009
  • DNA binding
    		•  1.17144894382542 bayes_pls_golite062009
  • protein kinase activity
    		•  0.688121376464754 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.672113434569322 bayes_pls_golite062009
  • molecular adaptor activity
    		•  0.657981592359252 bayes_pls_golite062009
  • kinase activity
    		•  0.613339968424942 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.57798177622409 bayes_pls_golite062009
  • transcription factor activity
    		•  0.573315212617741 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  0.559549509453052 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.370788151516215 bayes_pls_golite062009
  • signal transducer activity
    		•  0.150891693412241 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.150891693412241 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.10704587503284 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle