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View Structure Prediction Details

Protein: NBP2
Organism: Saccharomyces cerevisiae
Length: 236 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NBP2.

Description E-value Query
Range		 Subject
Range
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 5.0E-48 [16..213] [249..442]
SRC_RSVSA - Tyrosine-protein kinase transforming protein Src OS=Avian leukosis virus RSA GN=V-SRC PE=1 SV=5
gi|210189 - gi|210189|gb|AAA42565.1| src-p60 phosphoprotein
SRC_AVISR - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain rASV1441) GN=V-SRC P...
 8.0E-47 [16..213] [3..196]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 9.0E-47 [16..213] [3..196]
SRC_CHICK - Proto-oncogene tyrosine-protein kinase Src OS=Gallus gallus GN=SRC PE=1 SV=4
 9.0E-47 [16..213] [3..196]
SRC_AVISS - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S1) GN=V-SRC PE=3 SV...
 1.0E-46 [16..213] [3..196]
gi|210226 - gi|210226|gb|AAA42573.1| tyrosine-specific protein kinase
 3.0E-46 [16..213] [3..196]
SRC_AVIST - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S2) GN=V-SRC PE=3 SV...
 3.0E-46 [16..213] [3..196]
gi|190404884 - gi|190404884|gb|EDV08151.1| hypothetical protein SCRG_00361 [Saccharomyces cerevisiae RM11-1a]
NBP2_YEAST - NAP1-binding protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NBP2 PE=1 SV=1
gi|207346644 - gi|207346644|gb|EDZ73082.1| YDR162Cp-like protein [Saccharomyces cerevisiae AWRI1631]
NBP2 - Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recrui...
 3.0E-46 [1..236] [1..236]
gi|210265 - gi|210265|gb|AAA42583.1| p66-src protein
gi|394713 - gi|394713|emb|CAA36156.1| src protein [Avian sarcoma virus]
SRC_AVIS2 - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain PR2257) GN=V-SRC PE=...
 4.0E-46 [16..213] [3..196]

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Predicted Domain #1
Region A:
Residues: [1-103] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATMETTTQK DTNILKSGLK KTIGVLNEAV LQNGREVEAV QAGNSDTMED TETTTIGYIS  60
   61 IKDYAYADSN PLHYGYFDGD NEEDEMVSDS SNGEDTYNKR QSI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 3.12724619324809 bayes_pls_golite062009
protein binding 2.14586566310919 bayes_pls_golite062009
transcription regulator activity 1.38649262176488 bayes_pls_golite062009
nucleic acid binding 1.28138694351561 bayes_pls_golite062009
DNA binding 1.17144894382542 bayes_pls_golite062009
protein kinase activity 0.688121376464754 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.672113434569322 bayes_pls_golite062009
molecular adaptor activity 0.657981592359252 bayes_pls_golite062009
kinase activity 0.613339968424942 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.57798177622409 bayes_pls_golite062009
transcription factor activity 0.573315212617741 bayes_pls_golite062009
SH3/SH2 adaptor activity 0.559549509453052 bayes_pls_golite062009
protein binding, bridging 0.370788151516215 bayes_pls_golite062009
signal transducer activity 0.150891693412241 bayes_pls_golite062009
molecular transducer activity 0.150891693412241 bayes_pls_golite062009
kinase regulator activity 0.10704587503284 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [104-166] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLPDDYIVNQ RAVALYDFEP ENDNELRLAE GDIVFISYKH GQGWLVAENE SGSKTGLVPE  60
   61 EFV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.0
Match: 1qlyA_
Description: Bruton's tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [167-236] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYIQPEDGEN EVENKARPFY LTHLITQSVS PKNNIDNTNE DEYDDNDEWE DIDDVAEVEA  60
   61 DMKTKLDISD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.09691
Match: 1aotF_
Description: Tyrosine kinase Fyn
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle