Protein Overview: YCL073C

General Information:
Name(s) found:	YCL073C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|49066023\|sp\|P25596.4\|YCH0_YEAST RecName: Full=Uncharacterized membrane protein YCL073C [NCBI NR] gi\|14588896\|emb\|CAC42950.1\| hypothetical protein [Saccharomyces cerevisiae] [NCBI NR] gi\|10383750\|ref\|NP_009863.2\| Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W; Ycl073cp [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized membrane protein YCL073C OS=Saccharomyces cerevisiae GN=YCL073C PE=1 SV=4 [Swiss-Prot] Strong similarity toSiderophore iron transporters [mips] Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W [SGD] YCL073C, Chr III from 6479-8326, reverse complement [yeast_orfs2] Chr III from 6479-8326, reverse complement [yeastorf3.fasta] Chr III from 8326-6479, reverse complement [yeastorf5.fasta] (P25596) Hypothetical protein YCL073C [4932.FASTACCERV.txt] YCL073C SGDID:S0000575, Chr III from 8326-6479, reverse complement, Uncharacterized ORF [yeastflysequest.fasta] Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W [Saccharomyces cerevisiae]gi\|14588896\|emb\|CAC42950.1\| hypothetical protein [S [nrdb_11152004_Chlamydomonas] YCL073C SGDID:S000000575, Chr III from 8326-6479, reverse complement, Uncharacterized ORF, "Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to th [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Uncharacterized membrane protein YCL073C [nr-271106-contam.fasta] Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W; Ycl073cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] hypothetical protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YCL073C SGDID:S000000575, Chr III from 8326-6479, reverse complement, Uncharacterized ORF, "Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W" [yeast-bovrabprots.fasta] [chemostatdb.fasta] GEX1 SGDID:S000000575, Chr III from 8326-6479, Genome Release 64-1-1, reverse complement, Verified ORF, "Proton:glutathione antiporter localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway" [yeast-030211-contam.fasta] GEX1 SGDID:S000000575, Chr III from 8326-6479, Genome Release 64-2-1, reverse complement, Verified ORF, "Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; GEX1 has a paralog, GEX2, that arose from a segmental duplication" [20141208_orf_trans.fasta] YCL073C SGDID:S000000575, Chr III from 8326-6479, Genome Release 64-1-1, reverse complement, Verified ORF, "Proton:glutathione antiporter localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	615 amino acids
Gene Ontology:
Cellular Component:	membrane [ISS]
Biological Process:	transport [ISS]
Molecular Function:	transporter activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSVVGASS NKKSGIRQSC EIIERERHSN DDTYSMTSTF FKLKENEIMS AQFDSLKYKI  60
   61 LLISTAFVCG FGISLDYTLR STYTGYATNS YSEHSLLSTV QVINAVVSVG SQVVYSRLSD 120
  121 HFGRLRLFLV ATIFYIMGTI IQSQATRLTM YAAGSVFYNC GYVGTNLLLT LILSDFSSLK 180
  181 WRMFYQYASY WPYIIIPWIS GNIITAANPQ KNWSWNIAMW AFIYPLSALP IIFLILYMKY 240
  241 KSSKTAEWRS LKEQARKERT GGLFENLVFL FWKLDIVGIL LITVSLGCIL VPLTLANETS 300
  301 QKWHNSKIIA TLVSGGCLFF IFLYWEAKFA KSPLLPFKLL SDRGIWAPLG VTFFNFFTFF 360
  361 ISCDYLYPVL LVSMKESSTS AARIVNLPDF VAATASPFYS LLVAKTRKLK LSVIGGCAAW 420
  421 MVCMGLFYKY RGGSGSHEGV IAASVIMGLS GLLCSNSVIV ILQAMTTHSR MAVITGIQYT 480
  481 FSKLGAAIGA SVSGAIWTQT MPNQLYKNLG NDTLAEIAYA SPYTFISDYP WGSPERDAVV 540
  541 ESYRYVQRII MTVGLACTVP FFAFTMFMRD PELIDKATHE EFTEDGLVVL PDEENIFSQI 600
  601 KALFRHNRSN KKLGC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RGD2	YCL073C	2	Unpublished Fields Lab Data
View Screen	NAS2	YCL073C	2	Unpublished Fields Lab Data
View Screen	BUR2	YCL073C	2	Unpublished Fields Lab Data
View Screen	ROM2	YCL073C	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..406]	PSI-BLAST	5.39794	No description for 1ja5A_ was found.
2	View Details	[407..615]	MSA	3.62699	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	5.46247398538901	bayes_pls_golite062009
ion transmembrane transporter activity	4.58978526526921	bayes_pls_golite062009
cation transmembrane transporter activity	4.31967711223954	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
binding	1.26757615356623	bayes_pls_golite062009
anion transmembrane transporter activity	1.24023641504332	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2