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Protein Overview: LSB5

General Information:
Name(s) found: LSB5 / YCL034W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 354 amino acids

    Gene Ontology:
    Cellular Component: cell cortex [IDALink to PubMed article]
    Biological Process: actin filament organization [IPILink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFLSDHPHT AITETIFRIV SSRDYTLEVE LAPLIQLIKA DHNDYNYTVN QEEAARALRK  60
   61 KIKYGNRLQQ SRTLDLLDLF ISQGVKFTVM YNDDKLLQRL RGMATNSENS GSGEKYEPRI 120
  121 IKKCAAYAIS WLNYITQNNL ENARAYSGLY QLGQTVKQRY SKSSRSRRSG GGSGGRSNFM 180
  181 DDSADDTLYQ SNSLTSADRL YRIPQINMNK EAPRIRLIIS DALASAVSLQ NSLIGLPKGK 240
  241 FSTDDEEATS KFIQARAIRR KVLRYLQLVT EGEFLGSLIH ANDELVAALT AYDDRSAQDD 300
  301 SSDESDHGSY DDGIYDENEQ DNSRYIDSES SEEESLSSYQ PSTISNPFGD HNKI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LSB5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] ORFEUS 14.86 ADP-ribosylation factor binding protein Gga1
    2 View Details [92..168] ORFEUS 14.86 ADP-ribosylation factor binding protein Gga1
    3 View Details [169..354] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • clathrin binding
    		•  2.2051555354265 bayes_pls_golite062009
  • binding
    		•  2.04296681309629 bayes_pls_golite062009
  • protein binding
    		•  1.8451435695957 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  0.913711498494864 bayes_pls_golite062009
  • phospholipid binding
    		•  0.583709100639576 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.562042231995162 bayes_pls_golite062009
    2
    Term Confidence Notes
  • clathrin binding
    		•  3.56527129767546 bayes_pls_golite062009
  • binding
    		•  1.9253053687392 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.88822455907721 bayes_pls_golite062009
  • protein binding
    		•  1.65824069417195 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.30275072241927 bayes_pls_golite062009
  • phospholipid binding
    		•  1.04623877187105 bayes_pls_golite062009
  • lipid binding
    		•  0.447565169704067 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle