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Protein Overview: Eph-PE, Eph-PA

General Information:
Name(s) found: Eph-PE / FBpp0088155 [FlyBase]
Eph-PA / FBpp0088151 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • The gene Eph receptor tyrosine kinase is referred to in FlyBase by the symbol Dmel\Eph (CG1511, FBgn0025936). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:631312..641552. It has the cytological map location 102D1. Based on sequence similarity, it is predicted to have molecular function</span>: ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: mushroom body development. 12 alleles are reported. The phenotypes of these alleles are annotated with: medulla neuropil; commissure; lobula plate cortex; medulla cortex; longitudinal connective; mushroom body medial lobe; mushroom body vertical lobe; larval optic lobe; embryonic neuron. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Eph receptor tyrosine kinase is referred to in FlyBase by the symbol Dmel\Eph (CG1511, FBgn0025936). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:631312..641552. It has the cytological map location 102D1. Based on sequence similarity, it is predicted to have molecular function</span>: ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: mushroom body development. 12 alleles are reported. The phenotypes of these alleles are annotated with: medulla neuropil; commissure; lobula plate cortex; medulla cortex; longitudinal connective; mushroom body medial lobe; mushroom body vertical lobe; larval optic lobe; embryonic neuron. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1080 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IEA]
    plasma membrane [ISS]
    Biological Process: mushroom body development [IMP]
    signal transduction [ISS]
    axonogenesis [NAS]
    transmembrane receptor protein tyrosine kinase signaling pathway [IEA]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [NAS]
    protein binding [IEA]
    transmembrane receptor protein tyrosine kinase activity [ISS][NAS]
    ephrin receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKMVGCHPND KKVKYDGIKS KTSSVTILTS VLNDAISALK SAFYKNQAPI SEQNRSQIVS  60
   61 RMSLLRTILL IIISIHFKLA HADQVVLLDT TREATLEWTR YPYGPQAQTP GWVEESFTDF 120
  121 VKGINWRSYV VCDVAYHNVN NWLWSPFIDR GSANRLYIEI QFTIRDCSLF PGNALSCKET 180
  181 FSLLFYEFDA ATREPPPWQT DSYRLIARIA AGEGRFNQNS DVDINTEVKS IAVNKKGVYF 240
  241 AFRDQGACIS VLAVKVYYIT CPAVTENFAH FNETPTGREI TIIEKQNGTC VDNAEPYETP 300
  301 TYLCKGDGKW TILTGGCRCK AGYEPNYTNK TCTECPLGTF KSPEVTKCTP CPPNSNASKT 360
  361 GSPFCKCASG FYRHPNDGRH MPCYSPPAAP TNLTLLFVDQ TSAIISWSAP AKNESFSSET 420
  421 NSKIYHSDIV YKIKCNICSP NVVYNPSTDT FNETKITLTN LEPVTTYTVQ IHAINSVSHI 480
  481 NEFKRHSNES SLVAVSDIVF SNTSLLNIPL DLNEVKTGQA EIVFTTESVL LSTVFNLRIL 540
  541 AITNKDADLE WDKPVQSDFP LEFYEVRWFP KVELDAINKS ALNTKETKAH IVGLLENTEY 600
  601 GFQVRCKTNN GFGSYSNMIY AQTLQSVGSV YDDSVQIRFI AGAIVTGVLF LVIFIIATVY 660
  661 FMRSKHQDDL DKKSTNHLPL PLDYASNEVT TPLFGNSRSY VDPHTYEDPN QAIREFAREI 720
  721 DANYITIEAI IGGGEFGDVC RGRLKIPPNF VQDIDVAIKT LKPGSSEKAR CDFLTEASIM 780
  781 GQFDHPNVIY LQGVVTRSNP VMIITEYMEN GSLDTFLRVN DGKFQTLQLI VMLRGIASGM 840
  841 SYLSDMNYVH RDLAARNVLV NAQLICKIAD FGLSREIENA SDAYTTRGGK IPVRWTAPEA 900
  901 IAFRKFTSAS DVWSYGVVLW EVMSYGERPY WNWSNQDVIK SIEKGYRLPA PMDCPEALYQ 960
  961 LMLDCWQKQR THRPTFASIV STLDNLARQP QSLLTTRPSP ESDGNHILDG QRGQNIFIST1020
 1021 DLWLEHIKMS RYCHHFKEAN LINAQQISRL TAQQLSDMGI TLVGHQKKIL HQARQLDTII1080
 1081

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79] deduced N/A No confident structure predictions are available.
    2 View Details [80..287] PSI-BLAST 82.154902 Ligand-binding domain of the ephb2 receptor tyrosine kinase
    3 View Details [288..339] PSI-BLAST 6.0 Cytokine receptor gp130 cytokine-binding domains
    4 View Details [340..673] PSI-BLAST 13.39794 No description for 2dtgE was found.
    5 View Details [674..1000] PSI-BLAST 74.39794 No description for 2helA was found.
    6 View Details [1001..1080] PSI-BLAST 82.221849 No description for 2qoqA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • integrin binding
    		•  3.61193098087012 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.80879825615822 bayes_pls_golite062009
  • receptor activity
    		•  2.77268648576901 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.47762337031838 bayes_pls_golite062009
  • binding
    		•  2.31774167130542 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.23073603832866 bayes_pls_golite062009
  • phosphatidylserine binding
    		•  2.22270974208755 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.03595043486636 bayes_pls_golite062009
  • signal transducer activity
    		•  2.03595043486636 bayes_pls_golite062009
  • protein binding
    		•  1.90867517664953 bayes_pls_golite062009
  • fucose binding
    		•  1.72607684089801 bayes_pls_golite062009
  • protein kinase activity
    		•  1.70755634087208 bayes_pls_golite062009
  • monosaccharide binding
    		•  1.62596107035359 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.39122779055629 bayes_pls_golite062009
  • kinase activity
    		•  1.31546222648513 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.28997154411534 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.26743933952271 bayes_pls_golite062009
  • vascular endothelial growth factor receptor activity
    		•  1.21634643105777 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.18833031215069 bayes_pls_golite062009
  • sugar binding
    		•  1.1562287794497 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.68697655195721 bayes_pls_golite062009
  • protein complex binding
    		•  0.56054373949313 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.533285414042183 bayes_pls_golite062009
  • transferase activity
    		•  0.530643564656921 bayes_pls_golite062009
  • receptor binding
    		•  0.365344483970243 bayes_pls_golite062009
  • DNA binding
    		•  0.324772578014229 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.24891369301653 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.16022291279782 bayes_pls_golite062009
  • phosphatidylethanolamine binding
    		•  0.121022714964449 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • cytokine receptor activity
    		•  6.1064338595335 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.81256300373074 bayes_pls_golite062009
  • receptor activity
    		•  4.66147271961356 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • growth factor binding
    		•  4.06808996928726 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • signal transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  3.63249501085562 bayes_pls_golite062009
  • interleukin-6 binding
    		•  3.43159399159985 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  3.43159399159985 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • interleukin-11 binding
    		•  2.34894404420874 bayes_pls_golite062009
  • interleukin-11 receptor activity
    		•  2.34894404420874 bayes_pls_golite062009
  • ciliary neurotrophic factor binding
    		•  2.27923575030525 bayes_pls_golite062009
  • prolactin receptor activity
    		•  2.15346920063421 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  2.12450488436659 bayes_pls_golite062009
  • peptide hormone binding
    		•  2.12033076929638 bayes_pls_golite062009
  • SH2 domain binding
    		•  2.08068947938928 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.91712452737778 bayes_pls_golite062009
  • integrin binding
    		•  1.91458191628393 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  1.74022530568614 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  1.74022530568614 bayes_pls_golite062009
  • insulin binding
    		•  1.70967279462923 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.69642470905172 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.67132604890013 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.6158868405814 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  1.49133343034886 bayes_pls_golite062009
  • cytokine receptor binding
    		•  1.47680672146246 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42856560840953 bayes_pls_golite062009
  • heparin binding
    		•  1.40418056272895 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.15899955607967 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.12142142875217 bayes_pls_golite062009
  • kinase activity
    		•  1.11027658115625 bayes_pls_golite062009
  • cell surface binding
    		•  1.05599555585797 bayes_pls_golite062009
  • peptide binding
    		•  0.92031154055894 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.894667058714949 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • actin filament binding
    		•  0.848221254225135 bayes_pls_golite062009
  • PTB domain binding
    		•  0.76001954410963 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.657804692814791 bayes_pls_golite062009
  • ankyrin binding
    		•  0.56921114104552 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • transcription activator activity
    		•  0.529736394173061 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.522840770355105 bayes_pls_golite062009
  • hormone binding
    		•  0.49524185948356 bayes_pls_golite062009
  • peptidase activator activity
    		•  0.47985796351505 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.470959482317512 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • DNA binding
    		•  0.310798383307903 bayes_pls_golite062009
  • interleukin-7 binding
    		•  0.301052531308189 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.216119401508389 bayes_pls_golite062009
  • transcription factor binding
    		•  0.210682741845199 bayes_pls_golite062009
  • mercury ion binding
    		•  0.180077451915479 bayes_pls_golite062009
  • pattern binding
    		•  0.16768253393396 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • growth factor activity
    		•  0.0477008672713168 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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