| Protein: | Eph-PE, Eph-PA |
| Organism: | Drosophila melanogaster |
| Length: | 1080 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Eph-PE, Eph-PA.
| Description | E-value | Query Range |
Subject Range |
|
|
1009.0 | [0..46] | [1080..19] |
|
Region A: Residues: [1-79] |
1 11 21 31 41 51
| | | | | |
1 MKMVGCHPND KKVKYDGIKS KTSSVTILTS VLNDAISALK SAFYKNQAPI SEQNRSQIVS 60
61 RMSLLRTILL IIISIHFKL
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [80-287] |
1 11 21 31 41 51
| | | | | |
1 AHADQVVLLD TTREATLEWT RYPYGPQAQT PGWVEESFTD FVKGINWRSY VVCDVAYHNV 60
61 NNWLWSPFID RGSANRLYIE IQFTIRDCSL FPGNALSCKE TFSLLFYEFD AATREPPPWQ 120
121 TDSYRLIARI AAGEGRFNQN SDVDINTEVK SIAVNKKGVY FAFRDQGACI SVLAVKVYYI 180
181 TCPAVTENFA HFNETPTGRE ITIIEKQN
|
| Detection Method: | |
| Confidence: | 82.154902 |
| Match: | 1nukA |
| Description: | Ligand-binding domain of the ephb2 receptor tyrosine kinase |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| integrin binding | 3.61193098087012 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.80879825615822 | bayes_pls_golite062009 |
| receptor activity | 2.77268648576901 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 2.47762337031838 | bayes_pls_golite062009 |
| binding | 2.31774167130542 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 2.23073603832866 | bayes_pls_golite062009 |
| phosphatidylserine binding | 2.22270974208755 | bayes_pls_golite062009 |
| molecular transducer activity | 2.03595043486636 | bayes_pls_golite062009 |
| signal transducer activity | 2.03595043486636 | bayes_pls_golite062009 |
| protein binding | 1.90867517664953 | bayes_pls_golite062009 |
| fucose binding | 1.72607684089801 | bayes_pls_golite062009 |
| protein kinase activity | 1.70755634087208 | bayes_pls_golite062009 |
| monosaccharide binding | 1.62596107035359 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.39122779055629 | bayes_pls_golite062009 |
| kinase activity | 1.31546222648513 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.28997154411534 | bayes_pls_golite062009 |
| carbohydrate binding | 1.26743933952271 | bayes_pls_golite062009 |
| vascular endothelial growth factor receptor activity | 1.21634643105777 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 1.18833031215069 | bayes_pls_golite062009 |
| sugar binding | 1.1562287794497 | bayes_pls_golite062009 |
| glycoprotein binding | 0.68697655195721 | bayes_pls_golite062009 |
| protein complex binding | 0.56054373949313 | bayes_pls_golite062009 |
| nucleic acid binding | 0.533285414042183 | bayes_pls_golite062009 |
| transferase activity | 0.530643564656921 | bayes_pls_golite062009 |
| receptor binding | 0.365344483970243 | bayes_pls_golite062009 |
| DNA binding | 0.324772578014229 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 0.24891369301653 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 0.16022291279782 | bayes_pls_golite062009 |
| phosphatidylethanolamine binding | 0.121022714964449 | bayes_pls_golite062009 |
|
Region A: Residues: [288-339] |
1 11 21 31 41 51
| | | | | |
1 GTCVDNAEPY ETPTYLCKGD GKWTILTGGC RCKAGYEPNY TNKTCTECPL GT
|
| Detection Method: | |
| Confidence: | 6.0 |
| Match: | 1p9mA |
| Description: | Cytokine receptor gp130 cytokine-binding domains |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [340-673] |
1 11 21 31 41 51
| | | | | |
1 FKSPEVTKCT PCPPNSNASK TGSPFCKCAS GFYRHPNDGR HMPCYSPPAA PTNLTLLFVD 60
61 QTSAIISWSA PAKNESFSSE TNSKIYHSDI VYKIKCNICS PNVVYNPSTD TFNETKITLT 120
121 NLEPVTTYTV QIHAINSVSH INEFKRHSNE SSLVAVSDIV FSNTSLLNIP LDLNEVKTGQ 180
181 AEIVFTTESV LLSTVFNLRI LAITNKDADL EWDKPVQSDF PLEFYEVRWF PKVELDAINK 240
241 SALNTKETKA HIVGLLENTE YGFQVRCKTN NGFGSYSNMI YAQTLQSVGS VYDDSVQIRF 300
301 IAGAIVTGVL FLVIFIIATV YFMRSKHQDD LDKK
|
| Detection Method: | |
| Confidence: | 13.39794 |
| Match: | 2dtgE |
| Description: | No description for 2dtgE was found. |
| Term | Confidence | Notes |
| cytokine receptor activity | 6.1064338595335 | bayes_pls_golite062009 |
| transmembrane receptor activity | 4.81256300373074 | bayes_pls_golite062009 |
| receptor activity | 4.66147271961356 | bayes_pls_golite062009 |
| cytokine binding | 4.43581512268554 | bayes_pls_golite062009 |
| growth factor binding | 4.06808996928726 | bayes_pls_golite062009 |
| molecular transducer activity | 3.69234048247377 | bayes_pls_golite062009 |
| signal transducer activity | 3.69234048247377 | bayes_pls_golite062009 |
| ciliary neurotrophic factor receptor activity | 3.63249501085562 | bayes_pls_golite062009 |
| interleukin-6 binding | 3.43159399159985 | bayes_pls_golite062009 |
| interleukin-6 receptor activity | 3.43159399159985 | bayes_pls_golite062009 |
| protein binding | 3.24522318184038 | bayes_pls_golite062009 |
| binding | 3.12471204223368 | bayes_pls_golite062009 |
| interleukin-11 binding | 2.34894404420874 | bayes_pls_golite062009 |
| interleukin-11 receptor activity | 2.34894404420874 | bayes_pls_golite062009 |
| ciliary neurotrophic factor binding | 2.27923575030525 | bayes_pls_golite062009 |
| prolactin receptor activity | 2.15346920063421 | bayes_pls_golite062009 |
| growth hormone receptor activity | 2.12450488436659 | bayes_pls_golite062009 |
| peptide hormone binding | 2.12033076929638 | bayes_pls_golite062009 |
| SH2 domain binding | 2.08068947938928 | bayes_pls_golite062009 |
| axon guidance receptor activity | 2.01367445237355 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 1.91712452737778 | bayes_pls_golite062009 |
| integrin binding | 1.91458191628393 | bayes_pls_golite062009 |
| leukemia inhibitory factor receptor activity | 1.74022530568614 | bayes_pls_golite062009 |
| oncostatin-M receptor activity | 1.74022530568614 | bayes_pls_golite062009 |
| insulin binding | 1.70967279462923 | bayes_pls_golite062009 |
| polysaccharide binding | 1.69642470905172 | bayes_pls_golite062009 |
| interleukin-2 binding | 1.67132604890013 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 1.6158868405814 | bayes_pls_golite062009 |
| ciliary neurotrophic factor receptor binding | 1.49133343034886 | bayes_pls_golite062009 |
| cytokine receptor binding | 1.47680672146246 | bayes_pls_golite062009 |
| protein kinase activity | 1.42856560840953 | bayes_pls_golite062009 |
| heparin binding | 1.40418056272895 | bayes_pls_golite062009 |
| receptor binding | 1.31676259534833 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.15899955607967 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.12142142875217 | bayes_pls_golite062009 |
| kinase activity | 1.11027658115625 | bayes_pls_golite062009 |
| cell surface binding | 1.05599555585797 | bayes_pls_golite062009 |
| peptide binding | 0.92031154055894 | bayes_pls_golite062009 |
| interleukin-2 receptor activity | 0.894667058714949 | bayes_pls_golite062009 |
| protein dimerization activity | 0.86564366658585 | bayes_pls_golite062009 |
| actin filament binding | 0.848221254225135 | bayes_pls_golite062009 |
| PTB domain binding | 0.76001954410963 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.703490254739121 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.657804692814791 | bayes_pls_golite062009 |
| ankyrin binding | 0.56921114104552 | bayes_pls_golite062009 |
| identical protein binding | 0.564711394496051 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 0.554350228628563 | bayes_pls_golite062009 |
| transcription activator activity | 0.529736394173061 | bayes_pls_golite062009 |
| nucleic acid binding | 0.522840770355105 | bayes_pls_golite062009 |
| hormone binding | 0.49524185948356 | bayes_pls_golite062009 |
| peptidase activator activity | 0.47985796351505 | bayes_pls_golite062009 |
| transcription regulator activity | 0.470959482317512 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.46168925186147 | bayes_pls_golite062009 |
| transferase activity | 0.432850266451294 | bayes_pls_golite062009 |
| DNA binding | 0.310798383307903 | bayes_pls_golite062009 |
| interleukin-7 binding | 0.301052531308189 | bayes_pls_golite062009 |
| insulin receptor activity | 0.216119401508389 | bayes_pls_golite062009 |
| transcription factor binding | 0.210682741845199 | bayes_pls_golite062009 |
| mercury ion binding | 0.180077451915479 | bayes_pls_golite062009 |
| pattern binding | 0.16768253393396 | bayes_pls_golite062009 |
| protein heterodimerization activity | 0.1430595594485 | bayes_pls_golite062009 |
| protein homodimerization activity | 0.116391819218123 | bayes_pls_golite062009 |
| growth factor activity | 0.0477008672713168 | bayes_pls_golite062009 |
|
Region A: Residues: [674-1000] |
1 11 21 31 41 51
| | | | | |
1 STNHLPLPLD YASNEVTTPL FGNSRSYVDP HTYEDPNQAI REFAREIDAN YITIEAIIGG 60
61 GEFGDVCRGR LKIPPNFVQD IDVAIKTLKP GSSEKARCDF LTEASIMGQF DHPNVIYLQG 120
121 VVTRSNPVMI ITEYMENGSL DTFLRVNDGK FQTLQLIVML RGIASGMSYL SDMNYVHRDL 180
181 AARNVLVNAQ LICKIADFGL SREIENASDA YTTRGGKIPV RWTAPEAIAF RKFTSASDVW 240
241 SYGVVLWEVM SYGERPYWNW SNQDVIKSIE KGYRLPAPMD CPEALYQLML DCWQKQRTHR 300
301 PTFASIVSTL DNLARQPQSL LTTRPSP
|
| Detection Method: | |
| Confidence: | 74.39794 |
| Match: | 2helA |
| Description: | No description for 2helA was found. |
|
Region A: Residues: [1001-1080] |
1 11 21 31 41 51
| | | | | |
1 ESDGNHILDG QRGQNIFIST DLWLEHIKMS RYCHHFKEAN LINAQQISRL TAQQLSDMGI 60
61 TLVGHQKKIL HQARQLDTII
|
| Detection Method: | |
| Confidence: | 82.221849 |
| Match: | 2qoqA |
| Description: | No description for 2qoqA was found. |
