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View Structure Prediction Details

Protein: SUCLA2
Organism: Homo sapiens
Length: 463 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SUCLA2.

Description E-value Query
Range
Subject
Range
gi|34364605 - gi|34364605|emb|CAE45708.1| hypothetical protein [Homo sapiens]
0.0 [1..463] [10..472]
SUCLA2 - succinate-CoA ligase, ADP-forming, beta subunit
gi|114649575 - gi|114649575|ref|XP_001151014.1| PREDICTED: succinate-CoA ligase, ADP-forming, beta subunit isoform ...
0.0 [1..463] [1..463]
SUCB1_MOUSE - Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus GN=Sucla2 PE=1 SV=2
0.0 [1..463] [1..463]
SUCB1_BOVIN - Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Bos taurus GN=SUCLA2 PE=2 SV=1
0.0 [1..463] [1..463]
SUCB1_MACFA - Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Macaca fascicularis GN=SUCLA2 PE=2 ...
0.0 [1..463] [1..463]
gi|55731598, gi|... - gi|55731598|emb|CAH92506.1| hypothetical protein [Pongo abelii], gi|55725384|emb|CAH89556.1| hypothe...
gi|197098544 - gi|197098544|ref|NP_001124678.1| succinate-CoA ligase, ADP-forming, beta subunit [Pongo abelii]
0.0 [1..463] [1..463]
gi|109120693, gi... - gi|109120693|ref|XP_001099723.1| PREDICTED: succinate-CoA ligase, ADP-forming, beta subunit isoform ...
0.0 [1..463] [1..463]
gi|109502719, gi... - gi|62661722|ref|XP_341355.2| PREDICTED: similar to succinate-Coenzyme A ligase, ADP-forming, beta su...
0.0 [1..463] [1..465]

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Predicted Domain #1
Region A:
Residues: [1-54]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAASMFYGRL VAVATLRNHR PRTAQRAAAQ VLGSSGLFNN HGLQVQQQQQ RNLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.69897
Match: 2gpsA
Description: No description for 2gpsA was found.

Predicted Domain #2
Region A:
Residues: [55-463]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHEYMSMELL QEAGVSVPKG YVAKSPDEAY AIAKKLGSKD VVIKAQVLAG GRGKGTFESG  60
   61 LKGGVKIVFS PEEAKAVSSQ MIGKKLFTKQ TGEKGRICNQ VLVCERKYPR REYYFAITME 120
  121 RSFQGPVLIG SSHGGVNIED VAAESPEAII KEPIDIEEGI KKEQALQLAQ KMGFPPNIVE 180
  181 SAAENMVKLY SLFLKYDATM IEINPMVEDS DGAVLCMDAK INFDSNSAYR QKKIFDLQDW 240
  241 TQEDERDKDA AKANLNYIGL DGNIGCLVNG AGLAMATMDI IKLHGGTPAN FLDVGGGATV 300
  301 HQVTEAFKLI TSDKKVLAIL VNIFGGIMRC DVIAQGIVMA VKDLEIKIPV VVRLQGTRVD 360
  361 DAKALIADSG LKILACDDLD EAARMVVKLS EIVTLAKQAH VDVKFQLPI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.30103
Match: 2fp4B
Description: Crystal structure of pig GTP-specific succinyl-CoA synthetase in complex with GTP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
succinate-CoA ligase (GDP-forming) activity 9.38156037766008 bayes_pls_golite062009
succinate-CoA ligase activity 9.37213380498009 bayes_pls_golite062009
CoA-ligase activity 8.19630272128785 bayes_pls_golite062009
acid-thiol ligase activity 7.98453115335343 bayes_pls_golite062009
succinate-CoA ligase (ADP-forming) activity 7.27105019329796 bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds 7.23103788464777 bayes_pls_golite062009
ligase activity 3.25077459445999 bayes_pls_golite062009
ATP citrate synthase activity 3.09252003125984 bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 3.07329302783164 bayes_pls_golite062009
catalytic activity 2.5009559386228 bayes_pls_golite062009
CoA carboxylase activity 1.75094739650292 bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds 1.59015373957506 bayes_pls_golite062009
acetyl-CoA carboxylase activity 1.29064883699349 bayes_pls_golite062009
transferase activity, transferring acyl groups 1.15639517822408 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.992008268375695 bayes_pls_golite062009
binding 0.346654244533873 bayes_pls_golite062009
biotin carboxylase activity 0.0172732430077291 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle