YRC Public Data Repository - Protein Structure Prediction

Protein:	HMP_ECOLI
Organism:	Escherichia coli
Length:	396 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|197334385, gi... - gi\|197334385\|ref\|YP_002157112.1\| globin domain protein [Vibrio fischeri MJ11], gi\|197315875\|gb\|ACH65... gi\|59481024, gi\|... - gi\|59712923\|ref\|YP_205699.1\| nitric oxide dioxygenase [Vibrio fischeri ES114], gi\|59481024\|gb\|AAW868...	340.0	[0..1]	[396..1]
gi\|77958564 - gi\|77958564\|ref\|ZP_00822595.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1...	340.0	[0..1]	[396..1]
gi\|217320006, gi... - gi\|217327639\|ref\|ZP_03443722.1\| flavohemoprotein [Escherichia coli O157:H7 str. TW14588], gi\|2173200... gi\|209157780, gi... - gi\|209396380\|ref\|YP_002272026.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC4115], gi\|2091577... gi\|189378683, gi... - gi\|189378683\|gb\|EDU97099.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC508], gi\|168798930\|ref... gi\|189372293, gi... - gi\|189372293\|gb\|EDU90709.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC869], gi\|168787908\|ref... gi\|168778525, gi... - gi\|189003408\|gb\|EDU72394.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC4076], gi\|168778525\|re... gi\|168773526, gi... - gi\|187770656\|gb\|EDU34500.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC4196], gi\|168773526\|re... gi\|208741683, gi... - gi\|208821560\|ref\|ZP_03261880.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC4042], gi\|20874168... gi\|208812829, gi... - gi\|208812829\|ref\|ZP_03254158.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC4045], gi\|20873410... gi\|208725805, gi... - gi\|208806004\|ref\|ZP_03248341.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC4206], gi\|20872580... HMP_ECO57 - Flavohemoprotein OS=Escherichia coli O157:H7 GN=hmp PE=3 SV=1 gi\|195936699 - gi\|195936699\|ref\|ZP_03082081.1\| nitric oxide dioxygenase [Escherichia coli O157:H7 str. EC4024] gi\|254794501, gi... - gi\|254794501\|ref\|YP_003079338.1\| bifunctional nitric oxide dioxygenase [Escherichia coli O157:H7 str... gi\|168768652, gi... - gi\|189362227\|gb\|EDU80646.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC4486], gi\|168768652\|re... gi\|168761169, gi... - gi\|189368418\|gb\|EDU86834.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC4501], gi\|168761169\|re... gi\|168757790, gi... - gi\|189355293\|gb\|EDU73712.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC4401], gi\|168757790\|re... gi\|188017063, gi... - gi\|188017063\|gb\|EDU55185.1\| flavohemoprotein [Escherichia coli O157:H7 str. EC4113], gi\|168748382\|re... gi\|15832672, gi\|... - gi\|15832672\|ref\|NP_311445.1\| nitric oxide dioxygenase [Escherichia coli O157:H7 str. Sakai], gi\|1336... gi\|12516962, gi\|... - gi\|15803077\|ref\|NP_289108.1\| nitric oxide dioxygenase [Escherichia coli O157:H7 EDL933], gi\|12516962... gi\|209763034, gi... - pir\|\|F85900 dihydropteridine reductase [imported] - Escherichia coli (strain O157:H7, substrain EDL...	339.0	[0..1]	[396..1]
gi\|24052976, gi\|... - gi\|24113879\|ref\|NP_708389.1\| nitric oxide dioxygenase [Shigella flexneri 2a str. 301], gi\|24052976\|g... HMP_SHIFL - Flavohemoprotein OS=Shigella flexneri GN=hmp PE=3 SV=1 gi\|30063939, gi\|... - gi\|30063939\|ref\|NP_838110.1\| nitric oxide dioxygenase [Shigella flexneri 2a str. 2457T], gi\|30042195... gi\|110616030, gi... - gi\|110806482\|ref\|YP_690002.1\| nitric oxide dioxygenase [Shigella flexneri 5 str. 8401], gi\|110616030...	339.0	[0..1]	[396..1]
gi\|91073450, gi\|... - gi\|91211876\|ref\|YP_541862.1\| nitric oxide dioxygenase [Escherichia coli UTI89], gi\|91073450\|gb\|ABE08... gi\|226901426, gi... - gi\|237705060\|ref\|ZP_04535541.1\| nitric oxide dioxygenase [Escherichia sp. 3_2_53FAA], gi\|226901426\|g... gi\|218559472, gi... - gi\|218559472\|ref\|YP_002392385.1\| nitric oxide dioxygenase [Escherichia coli S88], gi\|218366241\|emb\|C... gi\|117624774, gi... - gi\|117624774\|ref\|YP_853687.1\| nitric oxide dioxygenase [Escherichia coli APEC O1], gi\|115513898\|gb\|A...	338.0	[0..1]	[396..1]
gi\|91188596, gi\|... - gi\|91227446\|ref\|ZP_01261810.1\| flavohemoprotein (flavohemoglobin) [Vibrio alginolyticus 12G01], gi\|9...	338.0	[0..1]	[396..1]
gi\|75515893 - gi\|75515893\|ref\|ZP_00738028.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1... gi\|75237702 - gi\|75237702\|ref\|ZP_00721718.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1... gi\|75196570 - gi\|75196570\|ref\|ZP_00706640.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1... gi\|75187305 - gi\|75187305\|ref\|ZP_00700572.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1... gi\|83586798 - gi\|83586798\|ref\|ZP_00925429.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1...	338.0	[0..1]	[396..8]
gi\|81246415, gi\|... - gi\|82545004\|ref\|YP_408951.1\| nitric oxide dioxygenase [Shigella boydii Sb227], gi\|81246415\|gb\|ABB671...	338.0	[0..1]	[396..1]
gi\|110642714, gi... - gi\|110642714\|ref\|YP_670444.1\| nitric oxide dioxygenase [Escherichia coli 536], gi\|110344306\|gb\|ABG70...	338.0	[0..1]	[396..1]
gi\|75178147 - gi\|75178147\|ref\|ZP_00698206.1\| COG1018: Flavodoxin reductases (ferredoxin-NADPH reductases) family 1...	337.0	[0..1]	[396..8]

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Predicted Domain #1

Region A:
Residues: [1-396]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDAQTIATV KATIPLLVET GPKLTAHFYD RMFTHNPELK EIFNMSNQRN GDQREALFNA  60
   61 IAAYASNIEN LPALLPAVEK IAQKHTSFQI KPEQYNIVGE HLLATLDEMF SPGQEVLDAW 120
  121 GKAYGVLANV FINREAEIYN ENASKAGGWE GTRDFRIVAK TPRSALITSF ELEPVDGGAV 180
  181 AEYRPGQYLG VWLKPEGFPH QEIRQYSLTR KPDGKGYRIA VKREEGGQVS NWLHNHANVG 240
  241 DVVKLVAPAG DFFMAVADDT PVTLISAGVG QTPMLAMLDT LAKAGHTAQV NWFHAAENGD 300
  301 VHAFADEVKE LGQSLPRFTA HTWYRQPSEA DRAKGQFDSE GLMDLSKLEG AFSDPTMQFY 360
  361 LCGPVGFMQF TAKQLVDLGV KQENIHYECF GPHKVL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	93.045757
Match:	1gvhA
Description:	Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxygen transporter activity	7.81281381234264	bayes_pls_golite062009
oxygen binding	3.78522064312431	bayes_pls_golite062009
hemoglobin binding	3.17505496298935	bayes_pls_golite062009
transporter activity	2.77225108027137	bayes_pls_golite062009
substrate-specific transporter activity	2.44807175467553	bayes_pls_golite062009
binding	1.56341797572673	bayes_pls_golite062009
catalytic activity	1.45374095556065	bayes_pls_golite062009
hemoglobin alpha binding	1.07662870695556	bayes_pls_golite062009
nitric-oxide synthase activity	0.943011064240739	bayes_pls_golite062009
transferase activity	0.708491789248912	bayes_pls_golite062009
riboflavin synthase activity	0.366634814975673	bayes_pls_golite062009
cofactor binding	0.365255270036622	bayes_pls_golite062009
oxidoreductase activity	0.27336340260908	bayes_pls_golite062009
coenzyme binding	0.270924422726986	bayes_pls_golite062009
protein binding	0.144900113694048	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: