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Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nitric-oxide synthase activity
Acc: GO:0004517
Aspect: Molecular Function
Desc: Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
Synonyms:
  • endothelium-derived relaxing factor synthase activity
  • L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity
  • nitric-oxide synthetase activity
  • NO synthase activity
  • nitric oxide synthase activity
  • nitric oxide synthetase activity
  • NADPH-diaphorase activity
  • endothelium-derived relaxation factor-forming enzyme activity
Proteins in PDR annotated with:
   This term: 17 [Search]
   Term or descendants: 17 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004517 - nitric-oxide synthase activity (interactive image map)
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Created and Maintained by: Michael Riffle