YRC Public Data Repository - Protein Structure Prediction

Protein:	GUAA_ECOLI
Organism:	Escherichia coli
Length:	525 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GUAA_ECOLI.

Description	E-value	Query Range	Subject Range
GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)... GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium GN=guaA PE=3 SV=1 GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium GN=guaA PE=3 SV=1	664.0	[0..1]	[525..1]
GUAA_SALPA - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=guaA P... GUAA_SALCH - GMP synthase [glutamine-hydrolyzing] OS=Salmonella choleraesuis (strain SC-B67) GN=guaA PE=3 SV=1 GUAA_SALCH - GMP synthase [glutamine-hydrolyzing] OS=Salmonella choleraesuis GN=guaA PE=3 SV=1 GUAA_SALPA - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi A GN=guaA PE=3 SV=1 GUAA_SALPC - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi C (strain RKS4594) GN=guaA PE=3 SV=1 gi\|204929457, gi... - gi\|204929457\|ref\|ZP_03220531.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. ent... GUAA_SALCH - GMP synthase [glutamine-hydrolyzing] OS=Salmonella choleraesuis GN=guaA PE=3 SV=1 GUAA_SALPK - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi A (strain AKU_12601) GN=guaA PE=3 SV=1 gi\|197243850, gi... - gi\|197265595\|ref\|ZP_03165669.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. ent... gi\|168466744, gi... - gi\|195630797\|gb\|EDX49389.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|205329878, gi... - gi\|205329878\|gb\|EDZ16642.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... GUAA_SALPB - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=guaA... GUAA_SALPB - GMP synthase [glutamine-hydrolyzing] OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=guaA... lcl\|NC_016856.1_... - [gene=guaA] [protein=bifunctional GMP synthase/glutamine amidotransferase protein] [protein_id=YP_00...	664.0	[0..1]	[525..1]
gi\|213425340 - gi\|213425340\|ref\|ZP_03358090.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... gi\|213622893 - gi\|213622893\|ref\|ZP_03375676.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... gi\|213852551 - gi\|213852551\|ref\|ZP_03382083.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... gi\|238913647 - gi\|238913647\|ref\|ZP_04657484.1\| GMP synthase [Salmonella enterica subsp. enterica serovar Tennessee ... gi\|214000302 - gi\|214000302\|ref\|ZP_03411037.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... GUAA_SALDC - GMP synthase [glutamine-hydrolyzing] OS=Salmonella dublin (strain CT_02021853) GN=guaA PE=3 SV=1 GUAA_SALG2 - GMP synthase [glutamine-hydrolyzing] OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=guaA P... GUAA_SALEP - GMP synthase [glutamine-hydrolyzing] OS=Salmonella enteritidis PT4 (strain P125109) GN=guaA PE=3 SV=... gi\|213160878 - gi\|213160878\|ref\|ZP_03346588.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmon... GUAA_SALTI - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhi GN=guaA PE=3 SV=1 gi\|205344986, gi... - gi\|205344986\|gb\|EDZ31750.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... GUAA_SALHS - GMP synthase [glutamine-hydrolyzing] OS=Salmonella heidelberg (strain SL476) GN=guaA PE=3 SV=1 gi\|194470386, gi... - gi\|194470386\|ref\|ZP_03076370.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. ent... GUAA_SALA4 - GMP synthase [glutamine-hydrolyzing] OS=Salmonella agona (strain SL483) GN=guaA PE=3 SV=1 gi\|205325488, gi... - gi\|205325488\|gb\|EDZ13327.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|168232074, gi... - gi\|205333635\|gb\|EDZ20399.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|168243285, gi... - gi\|205337568\|gb\|EDZ24332.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|205349448, gi... - gi\|205349448\|gb\|EDZ36079.1\| gmp synthase (glutamine-hydrolyzing) [Salmonella enterica subsp. enteric... gi\|29140876, gi\|... - gi\|29140876\|ref\|NP_804218.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmonell... gi\|16761427 - gi\|16761427\|ref\|NP_457044.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Salmonell... GUAA_SALTI - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhi GN=guaA PE=3 SV=1	663.0	[0..1]	[525..1]
GUAA_SHIF8 - GMP synthase [glutamine-hydrolyzing] OS=Shigella flexneri serotype 5b (strain 8401) GN=guaA PE=3 SV=...	660.0	[0..1]	[525..1]
gi\|195936649 - gi\|195936649\|ref\|ZP_03082031.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Escher... gi\|208728135, gi... - gi\|208808334\|ref\|ZP_03250671.1\| GMP synthetase [Escherichia coli O157:H7 str. EC4206], gi\|208728135\|... gi\|208812438, gi... - gi\|208812438\|ref\|ZP_03253767.1\| GMP synthetase [Escherichia coli O157:H7 str. EC4045], gi\|208733715\|... gi\|208819837, gi... - gi\|208819837\|ref\|ZP_03260157.1\| GMP synthetase [Escherichia coli O157:H7 str. EC4042], gi\|208739960\|... GUAA_ECO5E - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=guaA PE=3... GUAA_ECOSE - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain SE11) GN=guaA PE=3 SV=1 gi\|194432074, gi... - gi\|83570727\|ref\|ZP_00922170.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Shigella dysenteriae... gi\|217327698, gi... - gi\|217327698\|ref\|ZP_03443781.1\| GMP synthetase [Escherichia coli O157:H7 str. TW14588], gi\|217320065... GUAA_ECOHS - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O9:H4 (strain HS) GN=guaA PE=3 SV=1 GUAA_ECO8A - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O8 (strain IAI1) GN=guaA PE=3 SV=1 gi\|168761118, gi... - gi\|189368390\|gb\|EDU86806.1\| GMP synthase [Escherichia coli O157:H7 str. EC4501], gi\|168761118\|ref\|ZP... gi\|189362273, gi... - gi\|189362273\|gb\|EDU80692.1\| GMP synthase [Escherichia coli O157:H7 str. EC4486], gi\|168768599\|ref\|ZP... gi\|254794453, gi... - gi\|254794453\|ref\|YP_003079290.1\| GMP synthetase (glutamine aminotransferase) [Escherichia coli O157:... gi\|168773579, gi... - gi\|187770635\|gb\|EDU34479.1\| GMP synthase (glutamine-hydrolyzing) [Escherichia coli O157:H7 str. EC41... gi\|237705014, gi... - gi\|237705014\|ref\|ZP_04535495.1\| bifunctional GMP synthase/glutamine amidotransferase [Escherichia sp... gi\|168778473, gi... - gi\|189003283\|gb\|EDU72269.1\| GMP synthase [Escherichia coli O157:H7 str. EC4076], gi\|168778473\|ref\|ZP... gi\|227835889, gi... - gi\|227887539\|ref\|ZP_04005344.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Escher... GUAA_ECOUT - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain UTI89 / UPEC) GN=guaA PE=3 SV=1 gi\|168787853, gi... - gi\|189372276\|gb\|EDU90692.1\| GMP synthase [Escherichia coli O157:H7 str. EC869], gi\|168787853\|ref\|ZP_... gi\|13362839, gi\|... - gi\|15832623\|ref\|NP_311396.1\| GMP synthase [Escherichia coli O157:H7 str. Sakai], gi\|13362839\|dbj\|BAB... gi\|168798878, gi... - gi\|189378613\|gb\|EDU97029.1\| GMP synthase [Escherichia coli O157:H7 str. EC508], gi\|168798878\|ref\|ZP_... GUAA_ECOL5 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=guaA PE=3... GUAA_ECOLC - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=g... GUAA_ECOSM - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=guaA PE=3 SV=1 GUAA_ECO45 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=guaA PE=3 SV... GUAA_ECO81 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O81 (strain ED1a) GN=guaA PE=3 SV=1 GUAA_ECO55 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli (strain 55989 / EAEC) GN=guaA PE=3 SV=1 GUAA_ECO7I - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=guaA PE=3 S... GUAA_ECOL6 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O6 GN=guaA PE=3 SV=1 GUAA_ECO57 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O157:H7 GN=guaA PE=3 SV=1 gi\|209763452, gi... - pir\|\|A91050 GMP synthetase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952), ... GUAA_ECOL6 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) ... gi\|168748434, gi... - gi\|188017013\|gb\|EDU55135.1\| GMP synthase [Escherichia coli O157:H7 str. EC4113], gi\|168748434\|ref\|ZP... gi\|189356551, gi... - gi\|189356551\|gb\|EDU74970.1\| GMP synthase [Escherichia coli O157:H7 str. EC4401], gi\|168756279\|ref\|ZP... gi\|194414657, gi... - gi\|75211473\|ref\|ZP_00711563.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli B17... gi\|190902261, gi... - gi\|75229161\|ref\|ZP_00715733.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli B7A... gi\|75237747, gi\|... - gi\|75237747\|ref\|ZP_00721763.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli E11... gi\|190906762, gi... - gi\|75240144\|ref\|ZP_00724103.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli F11... gi\|75257314, gi\|... - gi\|75257314\|ref\|ZP_00728838.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli E22... gi\|188491634, gi... - gi\|75515847\|ref\|ZP_00737982.1\| COG0519: GMP synthase, PP-ATPase domain/subunit [Escherichia coli 536... GUAA_ECOK1 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O1:K1 / APEC GN=guaA PE=3 SV=1 gi\|124498700, gi... - gi\|124531254\|ref\|ZP_01701596.1\| GMP synthase, large subunit [Escherichia coli B], gi\|124498700\|gb\|EA...	660.0	[0..1]	[525..1]
GUAA_SHISS - GMP synthase [glutamine-hydrolyzing] OS=Shigella sonnei (strain Ss046) GN=guaA PE=3 SV=1	660.0	[0..1]	[525..1]
gi\|24113836, gi\|... - gi\|24113836\|ref\|NP_708346.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Shigella ... gi\|30042154, gi\|... - gi\|30063899\|ref\|NP_838070.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Shigella ... GUAA_SHIFL - GMP synthase [glutamine-hydrolyzing] OS=Shigella flexneri GN=guaA PE=3 SV=1	660.0	[0..1]	[525..1]
GUAA_SHIBS - GMP synthase [glutamine-hydrolyzing] OS=Shigella boydii serotype 4 (strain Sb227) GN=guaA PE=3 SV=1	660.0	[0..1]	[525..1]
GUAA_SHIB3 - GMP synthase [glutamine-hydrolyzing] OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=...	659.0	[0..1]	[525..1]
GUAA_PHOLL - GMP synthase [glutamine-hydrolyzing] OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 ... GUAA_PHOLL - GMP synthase [glutamine-hydrolyzing] OS=Photorhabdus luminescens subsp. laumondii GN=guaA PE=3 SV=1	659.0	[0..1]	[525..1]

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Predicted Domain #1

Region A:
Residues: [1-525]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTENIHKHRI LILDFGSQYT QLVARRVREL GVYCELWAWD VTEAQIRDFN PSGIILSGGP  60
   61 ESTTEENSPR APQYVFEAGV PVFGVCYGMQ TMAMQLGGHV EASNEREFGY AQVEVVNDSA 120
  121 LVRGIEDALT ADGKPLLDVW MSHGDKVTAI PSDFITVAST ESCPFAIMAN EEKRFYGVQF 180
  181 HPEVTHTRQG MRMLERFVRD ICQCEALWTP AKIIDDAVAR IREQVGDDKV ILGLSGGVDS 240
  241 SVTAMLLHRA IGKNLTCVFV DNGLLRLNEA EQVLDMFGDH FGLNIVHVPA EDRFLSALAG 300
  301 ENDPEAKRKI IGRVFVEVFD EEALKLEDVK WLAQGTIYPD VIESAASATG KAHVIKSHHN 360
  361 VGGLPKEMKM GLVEPLKELF KDEVRKIGLE LGLPYDMLYR HPFPGPGLGV RVLGEVKKEY 420
  421 CDLLRRADAI FIEELRKADL YDKVSQAFTV FLPVRSVGVM GDGRKYDWVV SLRAVETIDF 480
  481 MTAHWAHLPY DFLGRVSNRI INEVNGISRV VYDISGKPPA TIEWE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1gpmA
Description:	GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
anthranilate synthase activity	2.51214170411838	bayes_pls_golite062009
GMP synthase activity	2.47512732878183	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.4336980737244	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	2.18904295741925	bayes_pls_golite062009
phosphoribosylformylglycinamidine synthase activity	1.83575136996743	bayes_pls_golite062009
GMP synthase (glutamine-hydrolyzing) activity	1.81483405404572	bayes_pls_golite062009
ligase activity	1.7997907410336	bayes_pls_golite062009
carbamoyl-phosphate synthase activity	1.74828881793189	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	1.74029540439985	bayes_pls_golite062009
oxo-acid-lyase activity	1.35896725827905	bayes_pls_golite062009
catalytic activity	0.828867994386867	bayes_pls_golite062009
asparagine synthase (glutamine-hydrolyzing) activity	0.3673193848392	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.270391651600004	bayes_pls_golite062009
carbon-carbon lyase activity	0.0769356405014503	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: