YRC Public Data Repository - Protein Structure Prediction

Protein:	ENTE_ECOLI
Organism:	Escherichia coli
Length:	536 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ENTE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77996178, gi\|... - gi\|78044063\|ref\|YP_360551.1\| long-chain-fatty-acid--CoA ligase [Carboxydothermus hydrogenoformans Z-...	532.0	[0..5]	[535..7]
gi\|56419203, gi\|... - gi\|56419203\|ref\|YP_146521.1\| acyl-CoA synthetase [Geobacillus kaustophilus HTA426], gi\|56379045\|dbj\|...	524.0	[0..37]	[532..15]
gi\|55981432, gi\|... - gi\|55981432\|ref\|YP_144729.1\| long-chain-fatty-acid--CoA ligase [Thermus thermophilus HB8], gi\|557728...	522.0	[0..5]	[533..6]
gi\|46197026, gi\|... - gi\|46199401\|ref\|YP_005068.1\| long-chain-fatty-acid-CoA ligase [Thermus thermophilus HB27], gi\|461970...	518.0	[0..5]	[533..6]
gi\|52079510, gi\|... - gi\|52784875\|ref\|YP_090704.1\| acyl-CoA synthetase [Bacillus licheniformis ATCC 14580], gi\|52347377\|gb...	507.0	[0..33]	[534..11]
gi\|53763480, gi\|... - gi\|75910191\|ref\|YP_324487.1\| AMP-dependent synthetase and ligase [Anabaena variabilis ATCC 29413], g...	501.0	[0..25]	[535..1]
gi\|110641922, gi... - gi\|110641922\|ref\|YP_669652.1\| long-chain-fatty-acid--CoA ligase [Escherichia coli 536], gi\|110343514... gi\|75513698 - gi\|75513698\|ref\|ZP_00736074.1\| COG0318: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Esch... gi\|75255568 - gi\|75255568\|ref\|ZP_00727355.1\| COG0318: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Esch... gi\|75241326 - gi\|75241326\|ref\|ZP_00725177.1\| COG0318: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Esch... gi\|75227933 - gi\|75227933\|ref\|ZP_00714633.1\| COG0318: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Esch... gi\|75215166 - gi\|75215166\|ref\|ZP_00713611.1\| COG0318: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Esch... gi\|75208737 - gi\|75208737\|ref\|ZP_00709029.1\| COG0318: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Esch... gi\|124531917, gi... - gi\|124531917\|ref\|ZP_01702000.1\| AMP-dependent synthetase and ligase [Escherichia coli B], gi\|1244982... gi\|75195871 - gi\|75195871\|ref\|ZP_00705941.1\| COG0318: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Esch... tr\|A0A109ZPL0\|A0... - Long-chain fatty acid--CoA ligase OS=Escherichia coli (strain K12) GN=C3026_10285 PE=4 SV=1 gi\|75190835 - gi\|75190835\|ref\|ZP_00704102.1\| COG0318: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Esch... gi\|83584990 - gi\|83584990\|ref\|ZP_00923645.1\| COG0318: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Esch...	501.0	[0..2]	[535..14]

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Predicted Domain #1

Region A:
Residues: [1-536]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIPFTRWPE EFARRYREKG YWQDLPLTDI LTRHAASDSI AVIDGERQLS YRELNQAADN  60
   61 LACSLRRQGI KPGETALVQL GNVAELYITF FALLKLGVAP VLALFSHQRS ELNAYASQIE 120
  121 PALLIADRQH ALFSGDDFLN TFVTEHSSIR VVQLLNDSGE HNLQDAINHP AEDFTATPSP 180
  181 ADEVAYFQLS GGTTGTPKLI PRTHNDYYYS VRRSVEICQF TQQTRYLCAI PAAHNYAMSS 240
  241 PGSLGVFLAG GTVVLAADPS ATLCFPLIEK HQVNVTALVP PAVSLWLQAL IEGESRAQLA 300
  301 SLKLLQVGGA RLSATLAARI PAEIGCQLQQ VFGMAEGLVN YTRLDDSAEK IIHTQGYPMC 360
  361 PDDEVWVADA EGNPLPQGEV GRLMTRGPYT FRGYYKSPQH NASAFDANGF YCSGDLISID 420
  421 PEGYITVQGR EKDQINRGGE KIAAEEIENL LLRHPAVIYA ALVSMEDELM GEKSCAYLVV 480
  481 KEPLRAVQVR RFLREQGIAE FKLPDRVECV DSLPLTAVGK VDKKQLRQWL ASRASA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	129.0
Match:	1md9A
Description:	Dihydroxybenzoate-AMP ligase DhbE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming carbon-sulfur bonds	5.10123876514454	bayes_pls_golite062009
fatty acid ligase activity	4.83067429373059	bayes_pls_golite062009
long-chain fatty acid-CoA ligase activity	4.72692389032116	bayes_pls_golite062009
acetate-CoA ligase activity	4.48129067128523	bayes_pls_golite062009
acid-thiol ligase activity	4.28278725989432	bayes_pls_golite062009
CoA-ligase activity	4.12850865352867	bayes_pls_golite062009
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	2.74744781333102	bayes_pls_golite062009
Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity	2.74744781333102	bayes_pls_golite062009
luciferin monooxygenase activity	2.67396462766343	bayes_pls_golite062009
ligase activity	2.49556073715112	bayes_pls_golite062009
transcription regulator activity	2.31193176808353	bayes_pls_golite062009
catalytic activity	1.83545185797733	bayes_pls_golite062009
binding	1.5312519256537	bayes_pls_golite062009
transcription repressor activity	1.2638869228049	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.464663038956639	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: