YRC Public Data Repository - Protein Structure Prediction

Protein:	CYSP_ECOLI
Organism:	Escherichia coli
Length:	338 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYSP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91774975, gi\|... - gi\|91774975\|ref\|YP_544731.1\| thiosulphate-binding protein [Methylobacillus flagellatus KT], gi\|91708...	284.0	[0..1]	[335..1]
gi\|30248596, gi\|... - gi\|30248596\|ref\|NP_840666.1\| sulfate-/thiosulfate-binding protein [Nitrosomonas europaea ATCC 19718]...	284.0	[0..1]	[333..1]
gi\|78223113, gi\|... - gi\|78223113\|ref\|YP_384860.1\| thiosulphate-binding protein [Geobacter metallireducens GS-15], gi\|7819...	281.0	[0..25]	[337..26]
gi\|67873777, gi\|... - gi\|67873777\|ref\|ZP_00503764.1\| extracellular solute-binding protein, family 1 [Clostridium thermocel...	280.0	[0..9]	[336..1]
gi\|91687303, gi\|... - gi\|91783349\|ref\|YP_558555.1\| ABC sulfate/thiosulfate transporter, periplasmic ligand binding protein...	278.0	[0..18]	[336..30]
gi\|88937956, gi\|... - gi\|88937956\|ref\|ZP_01143481.1\| Thiosulphate-binding protein [Geobacter uraniumreducens Rf4], gi\|8891...	278.0	[0..3]	[337..4]
gi\|71549954, gi\|... - gi\|71549954\|ref\|ZP_00670114.1\| extracellular solute-binding protein, family 1 [Nitrosomonas eutropha...	275.0	[0..1]	[333..1]
gi\|188522864, gi... - gi\|188578412\|ref\|YP_001915341.1\| ABC transporter sulfate binding protein [Xanthomonas oryzae pv. ory... gi\|58583313, gi\|... - gi\|58583313\|ref\|YP_202329.1\| ABC transporter sulfate binding protein [Xanthomonas oryzae pv. oryzae ... gi\|84625142, gi\|... - gi\|84625142\|ref\|YP_452514.1\| ABC transporter sulfate binding protein [Xanthomonas oryzae pv. oryzae ...	275.0	[0..4]	[336..32]
gi\|89335152, gi\|... - gi\|89895704\|ref\|YP_519191.1\| hypothetical protein DSY2958 [Desulfitobacterium hafniense Y51], gi\|893...	275.0	[0..18]	[336..17]

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Predicted Domain #1

Region A:
Residues: [1-338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVNLLKKNS LALVASLLLA GHVQATELLN SSYDVSRELF AALNPPFEQQ WAKDNGGDKL  60
   61 TIKQSHAGSS KQALAILQGL KADVVTYNQV TDVQILHDKG KLIPADWQSR LPNNSSPFYS 120
  121 TMGFLVRKGN PKNIHDWNDL VRSDVKLIFP NPKTSGNARY TYLAAWGAAD KADGGDKGKT 180
  181 EQFMTQFLKN VEVFDTGGRG ATTTFAERGL GDVLISFESE VNNIRKQYEA QGFEVVIPKT 240
  241 NILAEFPVAW VDKNVQANGT EKAAKAYLNW LYSPQAQTII TDYYYRVNNP EVMDKLKDKF 300
  301 PQTELFRVED KFGSWPEVMK THFTSGGELD KLLAAGRN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.0
Match:	1sbpA
Description:	1.7 ANGSTROMS REFINED STRUCTURE OF SULFATE-BINDING PROTEIN INVOLVED IN ACTIVE TRANSPORT AND NOVEL MODE OF SULFATE BINDING
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
sulfate transmembrane transporter activity	9.92004408243522	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	7.48200101527962	bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity	7.45486761585167	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	7.32513858490159	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	7.32461921873446	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	7.32461921873446	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	7.30967709770689	bayes_pls_golite062009
primary active transmembrane transporter activity	7.29915074349679	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	7.26077080183261	bayes_pls_golite062009
active transmembrane transporter activity	7.22701734359888	bayes_pls_golite062009
ATPase activity, coupled	6.6184830833742	bayes_pls_golite062009
molybdate ion transmembrane transporter activity	6.34546911558439	bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity	6.34546911558439	bayes_pls_golite062009
ATPase activity	6.25872881857398	bayes_pls_golite062009
nucleoside-triphosphatase activity	5.90322606085411	bayes_pls_golite062009
pyrophosphatase activity	5.82359353784758	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	5.80191380928519	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	5.80159621701122	bayes_pls_golite062009
anion transmembrane transporter activity	4.89460549572351	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.68307627076676	bayes_pls_golite062009
sulfate binding	4.65876779710695	bayes_pls_golite062009
ion transmembrane transporter activity	4.22641590829276	bayes_pls_golite062009
hydrolase activity	4.03317966718526	bayes_pls_golite062009
transporter activity	3.92658561501282	bayes_pls_golite062009
transmembrane transporter activity	3.71430307970333	bayes_pls_golite062009
substrate-specific transporter activity	3.34421502810243	bayes_pls_golite062009
molybdate ion binding	3.13132983078262	bayes_pls_golite062009
peptide transporter activity	3.10283389778901	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	2.62312131886704	bayes_pls_golite062009
cation transmembrane transporter activity	2.43161220346794	bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity	2.21967608673197	bayes_pls_golite062009
phosphate transmembrane transporter activity	1.98762819035198	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.91835671279657	bayes_pls_golite062009
oligopeptide transporter activity	1.91036692266394	bayes_pls_golite062009
iron ion transmembrane transporter activity	1.89277079721748	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.86547682033752	bayes_pls_golite062009
peptide-transporting ATPase activity	1.6237462710009	bayes_pls_golite062009
binding	1.54172013140566	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.87250689444675	bayes_pls_golite062009
polyamine transmembrane transporter activity	0.74959887541426	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	0.413290267914678	bayes_pls_golite062009
molybdenum ion binding	0.391548805174721	bayes_pls_golite062009
amine transmembrane transporter activity	0.372828805396439	bayes_pls_golite062009
amine-transporting ATPase activity	0.22884273975653	bayes_pls_golite062009
polyamine-transporting ATPase activity	0.0497853931936705	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: