YRC Public Data Repository - Protein Structure Prediction

Protein:	3MG2_ECOLI
Organism:	Escherichia coli
Length:	282 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for 3MG2_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|74312593, gi\|... - gi\|74312593\|ref\|YP_311012.1\| 3-methyl-adenine DNA glycosylase II [Shigella sonnei Ss046], gi\|7385607...	254.0	[0..1]	[282..1]
gi\|82543443, gi\|... - gi\|82543443\|ref\|YP_407390.1\| 3-methyl-adenine DNA glycosylase II [Shigella boydii Sb227], gi\|8124485...	253.0	[0..1]	[280..1]
gi\|208820921, gi... - gi\|208820921\|ref\|ZP_03261241.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC4... gi\|208817208, gi... - gi\|208817208\|ref\|ZP_03258300.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC4... gi\|208807527, gi... - gi\|208807527\|ref\|ZP_03249864.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC4... gi\|195938262 - gi\|195938262\|ref\|ZP_03083644.1\| 3-methyl-adenine DNA glycosylase II [Escherichia coli O157:H7 str. E... gi\|217317319, gi... - gi\|217329551\|ref\|ZP_03445630.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. TW1... gi\|209400907, gi... - gi\|209400907\|ref\|YP_002271312.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC... gi\|189361278, gi... - gi\|189361278\|gb\|EDU79697.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC4486]... gi\|189367828, gi... - gi\|189367828\|gb\|EDU86244.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC4501]... gi\|168757969, gi... - gi\|189355123\|gb\|EDU73542.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC4401]... gi\|188015389, gi... - gi\|188015389\|gb\|EDU53511.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC4113]... gi\|15832131, gi\|... - gi\|15832131\|ref\|NP_310904.1\| 3-methyl-adenine DNA glycosylase II [Escherichia coli O157:H7], gi\|1336... gi\|168799047, gi... - gi\|189378476\|gb\|EDU96892.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC508],... gi\|209747990, gi... - pir\|\|G85833 3-methyl-adenine DNA glycosylase II, inducible [imported] - Escherichia coli (strain O15... gi\|168788740, gi... - gi\|189371536\|gb\|EDU89952.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC869],... gi\|189000174, gi... - gi\|189000174\|gb\|EDU69160.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC4076]... gi\|15802549, gi\|... - gi\|15802549\|ref\|NP_288576.1\| 3-methyl-adenine DNA glycosylase II [Escherichia coli O157:H7 EDL933], ... gi\|187768916, gi... - gi\|187768916\|gb\|EDU32760.1\| DNA-3-methyladenine glycosylase 2 [Escherichia coli O157:H7 str. EC4196]... gi\|254793853, gi... - gi\|254793853\|ref\|YP_003078690.1\| 3-methyl-adenine DNA glycosylase II [Escherichia coli O157:H7 str. ... gi\|15832131, gi\|... - gi\|15832131\|ref\|NP_310904.1\| 3-methyl-adenine DNA glycosylase II [Escherichia coli O157:H7 str. Saka...	253.0	[0..1]	[282..1]
gi\|75259206, gi\|... - gi\|75259206\|ref\|ZP_00730554.1\| COG0122: 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase...	253.0	[0..1]	[280..1]
gi\|81241570, gi\|... - gi\|82777422\|ref\|YP_403771.1\| 3-methyl-adenine DNA glycosylase II [Shigella dysenteriae Sd197], gi\|81...	252.0	[0..1]	[282..1]
gi\|193069296, gi... - gi\|75236264\|ref\|ZP_00720373.1\| COG0122: 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase... gi\|75227907, gi\|... - gi\|75227907\|ref\|ZP_00714611.1\| COG0122: 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase... gi\|194413218, gi... - gi\|75210002\|ref\|ZP_00710185.1\| COG0122: 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase... gi\|157079966, gi... - gi\|75186866\|ref\|ZP_00700133.1\| COG0122: 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase...	252.0	[0..1]	[280..1]
gi\|188487029, gi... - gi\|75514100\|ref\|ZP_00736430.1\| COG0122: 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase...	252.0	[0..1]	[282..1]
gi\|194431395, gi... - gi\|83571204\|ref\|ZP_00922645.1\| COG0122: 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase...	251.0	[0..1]	[280..1]
gi\|157161558, gi... - gi\|75196123\|ref\|ZP_00706193.1\| COG0122: 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase...	251.0	[0..1]	[282..1]
gi\|26108848, gi\|... - gi\|26248443\|ref\|NP_754483.1\| 3-methyl-adenine DNA glycosylase II [Escherichia coli CFT073], gi\|26108...	249.0	[0..1]	[282..1]

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Predicted Domain #1

Region A:
Residues: [1-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYTLNWQPPY DWSWMLGFLA ARAVSSVETV ADSYYARSLA VGEYRGVVTA IPDIARHTLH  60
   61 INLSAGLEPV AAECLAKMSR LFDLQCNPQI VNGALGRLGA ARPGLRLPGC VDAFEQGVRA 120
  121 ILGQLVSVAM AAKLTARVAQ LYGERLDDFP EYICFPTPQR LAAADPQALK ALGMPLKRAE 180
  181 ALIHLANAAL EGTLPMTIPG DVEQAMKTLQ TFPGIGRWTA NYFALRGWQA KDVFLPDDYL 240
  241 IKQRFPGMTP AQIRRYAERW KPWRSYALLH IWYTEGWQPD EA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.154902
Match:	1dizA
Description:	3-Methyladenine DNA glycosylase II (gene alkA or aidA)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA N-glycosylase activity	4.08559331236111	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	3.73234184319832	bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity	3.12421941323765	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	2.54759386266723	bayes_pls_golite062009
catalytic activity	2.50389926428623	bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity	1.80199518353554	bayes_pls_golite062009
alkylbase DNA N-glycosylase activity	1.75218522602775	bayes_pls_golite062009
hydrolase activity	1.39000450534744	bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity	1.14337995879633	bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity	0.473206156100251	bayes_pls_golite062009
uracil DNA N-glycosylase activity	0.29478804124408	bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity	0.253198605718519	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.0593430405945699	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.0274101501785404	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: