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View Structure Prediction Details

Protein: PMS1
Organism: Saccharomyces cerevisiae
Length: 873 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PMS1.

Description E-value Query
Range
Subject
Range
PMS1_YEAST - DNA mismatch repair protein PMS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PMS1 PE...
gi|190409071 - gi|190409071|gb|EDV12336.1| DNA mismatch repair protein PMS1 [Saccharomyces cerevisiae RM11-1a]
PMS1 - ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer ...
gi|151944452 - gi|151944452|gb|EDN62730.1| postmeiotic segregation protein [Saccharomyces cerevisiae YJM789]
0.0 [1..873] [1..873]
gi|21619309 - gi|21619309|gb|AAH31832.1| PMS2 protein [Homo sapiens]
0.0 [4..861] [32..873]

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Predicted Domain #1
Region A:
Residues: [1-403]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQIHQINDI DVHRITSGQV ITDLTTAVKE LVDNSIDANA NQIEIIFKDY GLESIECSDN  60
   61 GDGIDPSNYE FLALKHYTSK IAKFQDVAKV QTLGFRGEAL SSLCGIAKLS VITTTSPPKA 120
  121 DKLEYDMVGH ITSKTTTSRN KGTTVLVSQL FHNLPVRQKE FSKTFKRQFT KCLTVIQGYA 180
  181 IINAAIKFSV WNITPKGKKN LILSTMRNSS MRKNISSVFG AGGMRGLEEV DLVLDLNPFK 240
  241 NRMLGKYTDD PDFLDLDYKI RVKGYISQNS FGCGRNSKDR QFIYVNKRPV EYSTLLKCCN 300
  301 EVYKTFNNVQ FPAVFLNLEL PMSLIDVNVT PDKRVILLHN ERAVIDIFKT TLSDYYNRQE 360
  361 LALPKRMCSQ SEQQAQKRLK TEVFDDRSTT HESDNENYHT ARS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.39794
Match: 1ea6A_
Description: DNA mismatch repair protein PMS2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mismatched DNA binding 8.69038541722775 bayes_pls_golite062009
DNA insertion or deletion binding 7.03361327424191 bayes_pls_golite062009
6.04882684441736 bayes_pls_golite062009
guanine/thymine mispair binding 5.8954303695758 bayes_pls_golite062009
mismatch repair complex binding 5.63566878749852 bayes_pls_golite062009
single base insertion or deletion binding 5.36719395837475 bayes_pls_golite062009
dinucleotide insertion or deletion binding 4.91072939712457 bayes_pls_golite062009
loop DNA binding 4.26052361441101 bayes_pls_golite062009
DNA topoisomerase (ATP-hydrolyzing) activity 2.66323092512867 bayes_pls_golite062009
DNA topoisomerase activity 2.35776058207527 bayes_pls_golite062009
protein kinase activity 2.13536672517084 bayes_pls_golite062009
catalytic activity 2.10890475146569 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.77725015786603 bayes_pls_golite062009
kinase activity 1.68443268281997 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.64025200399404 bayes_pls_golite062009
transcription regulator activity 1.37978051130887 bayes_pls_golite062009
DNA binding 1.31521246060081 bayes_pls_golite062009
structure-specific DNA binding 1.22640171545155 bayes_pls_golite062009
nucleic acid binding 1.22084067619837 bayes_pls_golite062009
transferase activity 1.09369139087478 bayes_pls_golite062009
exonuclease activity 1.02947145936572 bayes_pls_golite062009
molecular transducer activity 0.996368427522977 bayes_pls_golite062009
signal transducer activity 0.996368427522977 bayes_pls_golite062009
double-stranded DNA binding 0.91402301750067 bayes_pls_golite062009
binding 0.908938377164829 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.86218415868631 bayes_pls_golite062009
MutSalpha complex binding 0.8423412194292 bayes_pls_golite062009
single-stranded DNA binding 0.839521076707668 bayes_pls_golite062009
ribonuclease activity 0.75307991342421 bayes_pls_golite062009
structural constituent of ribosome 0.71251019785001 bayes_pls_golite062009
nuclease activity 0.69721312877891 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.48105441429954 bayes_pls_golite062009
3'-5' exonuclease activity 0.477960254167 bayes_pls_golite062009
structural molecule activity 0.41673693977319 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.36703663415044 bayes_pls_golite062009
exoribonuclease activity 0.350394896843651 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [404-590]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESNQSNHAHF NSTTGVIDKS NGTELTSVMD GNYTNVTDVI GSECEVSVDS SVVLDEGNSS  60
   61 TPTKKLPSIK TDSQNLSDLN LNNFSNPEFQ NITSPDKARS LEKVVEEPVY FDIDGEKFQE 120
  121 KAVLSQADGL VFVDNECHEH TNDCCHQERR GSTDTEQDDE ADSIYAEIEP VEINVRTPLK 180
  181 NSRKSIS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [591-733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDNYRSLSDG LTHRKFEDEI LEYNLSTKNF KEISKNGKQM SSIISKRKSE AQENIIKNKD  60
   61 ELEDFEQGEK YLTLTVSKND FKKMEVVGQF NLGFIIVTRK VDNKYDLFIV DQHASDEKYN 120
  121 FETLQAVTVF KSQKLIIPQP VEL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [734-826]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVIDELVVLD NLPVFEKNGF KLKIDEEEEF GSRVKLLSLP TSKQTLFDLG DFNELIHLIK  60
   61 EDGGLRRDNI RCSKIRSMFA MRACRSSIMI GKP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [827-873]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNKKTMTRVV HNLSELDKPW NCPHGRPTMR HLMELRDWSS FSKDYEI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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