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View Structure Prediction Details

Protein: gi|6579197, gi|1...
Organism: Arabidopsis thaliana
Length: 2271 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|6579197, gi|1....

Description E-value Query
Range
Subject
Range
POLE - polymerase (DNA directed), epsilon
2241.0 [0..2] [2269..19]

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Predicted Domain #1
Region A:
Residues: [1-62]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGDNRRRDR KDTRWSKKPK VVNTAEDELE SKLGFGLFSE GETRLGWLLT FSSSSWEDRD  60
   61 TG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 123.0
Match: 2gv9A
Description: No description for 2gv9A was found.

Predicted Domain #2
Region A:
Residues: [63-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVYSCVDLYF VTQDGFSFKT KYKFRPYFYA ATKDKMELEL EAYLRRRYER QVADIEIVEK  60
   61 EDLDLKNHLS GLQKKYLKIS FDTV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 105.0
Match: 1qhtA
Description: Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [147-1131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQLMEVKRDL LHIVERNQAK FDALEAYESI LAGKREQRPQ DCLDSIVDLR EYDVPYHVRF  60
   61 AIDNDVRSGQ WYNVSISSTD VILEKRTDLL QRAEVRVCAF DIETTKLPLK FPDAEYDQIM 120
  121 MISYMVDGQG FLIINREVTA CVGEDVEDLE YTPKPEFEGY FKVTNVKNEV ELLQRWFYHM 180
  181 QELKPGIYVT YNGDFFDWPF IERRASHHGI KMNEELGFRC DQNQGECRAK FACHLDCFAW 240
  241 VKRDSYLPQG SHGLKAVTKA KLGYDPLEVN PEDMVRFAME KPQTMASYSV SDAVATYYLY 300
  301 MTYVNPFIFS LATIIPMVPD EVLRKGSGTL CEMLLMVEVS TYLPQAQAYK ANVVCPNKNQ 360
  361 ADPEKFYQNQ LLESETYIGG HVECLESGQL IDNLGRDLEY AITVEGKMRM DSISNYDEVK 420
  421 DEIKEKLEKL RDDPIREEGP LIYHLDVAAM YPNIILTNRL QVHLISPPSI VTDEICTACD 480
  481 FNRPGKTCLR KLEWVWRGVT FMGKKSDYYH LKKQIESEFV DAGANIMSSK SFLDLPKVDQ 540
  541 QSKLKERLKK YCQKAYKRVL DKPITEVREA GICMRENPFY VDTVRSFRDR RYEYKTLNKV 600
  601 WKGKLSEAKA SGNSIKIQEA QDMVVVYDSL QLAHKCILNS FYGYVMRKGA RWYSMEMAGV 660
  661 VTYTGAKIIQ NARLLIERIG KPLELDTDGI WCCLPGSFPE NFTFKTIDMK KLTISYPCVM 720
  721 LNVDVAKNNT NDQYQTLVDP VRKTYKSHSE CSIEFEVDGP YKAMIIPASK EEGILIKKRY 780
  781 AVFNHDGTLA ELKGFEIKRR GELKLIKVFQ AELFDKFLHG STLEECYSAV AAVADRWLDL 840
  841 LDVCEISCFF WVIYLIGFLS HFLQNQGKDI ADSELLDYIS ESSTMSKSLA DYGEQKSCAV 900
  901 TTAKRLAEFL GVTMVKDKGL RCQYIVACEP KGTPVSERAV PVAIFTTNPE VMKFHLRKWC 960
  961 KTSSDVGIRL IIDWSYYKQR LSSAI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.0
Match: 1q9yA
Description: CRYSTAL STRUCTURE OF ENTEROBACTERIA PHAGE RB69 GP43 DNA POLYMERASE COMPLEXED WITH 8-OXOGUANOSINE CONTAINING DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA-directed DNA polymerase activity 11.2781960093187 bayes_pls_golite062009
DNA polymerase activity 11.2285838712952 bayes_pls_golite062009
nucleotidyltransferase activity 8.85826259809475 bayes_pls_golite062009
DNA primase activity 7.3506495327575 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.79232184185512 bayes_pls_golite062009
endonuclease activity 4.4589129578563 bayes_pls_golite062009
endodeoxyribonuclease activity 4.26114862034453 bayes_pls_golite062009
transferase activity 4.02382113115178 bayes_pls_golite062009
deoxyribonuclease activity 2.58611070700103 bayes_pls_golite062009
RNA polymerase activity 2.29514625858236 bayes_pls_golite062009
DNA-directed RNA polymerase activity 2.29514625858236 bayes_pls_golite062009
ribonuclease activity 2.10426652514018 bayes_pls_golite062009
exonuclease activity 1.68989335095363 bayes_pls_golite062009
binding 1.63261093703427 bayes_pls_golite062009
nucleic acid binding 1.62213678119562 bayes_pls_golite062009
DNA binding 1.55767764828811 bayes_pls_golite062009
damaged DNA binding 1.08077297289305 bayes_pls_golite062009
catalytic activity 1.04899053677564 bayes_pls_golite062009
transcription regulator activity 0.863544378011356 bayes_pls_golite062009
exoribonuclease activity 0.85780161294346 bayes_pls_golite062009
3'-5' exonuclease activity 0.78558451404229 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.78013028675591 bayes_pls_golite062009
structure-specific DNA binding 0.433956339585542 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.43313823287883 bayes_pls_golite062009
chromatin binding 0.382725239240319 bayes_pls_golite062009
nuclease activity 0.332024848299731 bayes_pls_golite062009
DNA helicase activity 0.283883977748512 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.262305398570872 bayes_pls_golite062009
protein binding 0.254364110020667 bayes_pls_golite062009
single-stranded DNA binding 0.206750180223289 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 0.19596408995795 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.193854882336037 bayes_pls_golite062009
5'-3' exonuclease activity 0.154583332107704 bayes_pls_golite062009
transcription factor activity 0.093362945686819 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [1132-1242]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKVITIPAAM QKVANPVPRV LHPDWLHKKV REKDDKFRQR KLVDMFSSAN KDVVLDTDLP  60
   61 VTKDNVEDIE DFCKENRPSV KGPKPIARSY EVNKKQSECE QQESWDTEFH D

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1243-2096]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISFQNIDKSV NYQGWLELKK RKWKVTLEKK KKRRLGDLRS SNQVDTHEIN QKVGQGRGGV  60
   61 GSYFRRPEEA LTSSHWQVCT IIQLVPSPQS GQFFAWVVVE GLMLKIPLSI PRVFYINSKV 120
  121 PIDEYFQGKC VNKILPHGRP CYSLTEACVK IQEDQFKKES KKRAALLADP GVEGIYETKV 180
  181 PLEFSAICQI GCVCKIDNKA KHRNTQDGWE VGELHMKTTT ECHYLKRSIP LVYLYNSTST 240
  241 GRAIYVLYCH VSKLMSAVVV DPFNGNELLP SALERQFRDS CLELSLDSLS WDGIRFQVHY 300
  301 VDHPEAAKKI IQRAISEYRE ENCGPTVAVI ECPDFTFMKE GIKALDDFPC VRIPFNDDDN 360
  361 SYQPVSWQRP AAKIAMFRCA AAFQWLDRRI TQSRYAHVPL GNFGLDWLTF TIDIFLSRAL 420
  421 RDQQQVLWVS DNGVPDLGGI NNEEAFFADE VQQTSLVFPG AYRKVSVELK IHNLAVNALL 480
  481 KSNLVNEMEG GGFMGFEQDV NPRGINSNDN TSFDETTGCA QAFRVLKQLI HSCLTDVRKS 540
  541 KNIYADSILQ RLSWWLCSPS SKLHDPALHL MLHKVMQKVF ALLLTDLRRL GAIIIYADFS 600
  601 KVIIDTVKFD LSAAKAYCES LLSTVRNRLV SSLLDIHVYD LKSHGLHSFS CHDFCASPLT 660
  661 YNYAGIRADD EISLDEVTIE PKWSVARHLP EYIEVWRQNP HSNQCSFSEN KKHVATHGPF 720
  721 FLDTDAFHLS WQRDFIIIIA KFIFDPWKFA IENKKGSSES LEAQMIEYLR EQIGSTFINM 780
  781 LVKKVDDIMS HMKEINVSDA SRVSGQAPKG DYSLEFIQVI SAVLALDQNV QQDVLLKTLF 840
  841 ITDFIHKSNL ISGN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.7
Match: 1q8iA
Description: Crystal structure of ESCHERICHIA coli DNA Polymerase II
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA-directed DNA polymerase activity 10.6911520838834 bayes_pls_golite062009
DNA polymerase activity 10.645713605123 bayes_pls_golite062009
nucleotidyltransferase activity 8.39147983801981 bayes_pls_golite062009
DNA primase activity 6.94341770434315 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.49699229430126 bayes_pls_golite062009
endonuclease activity 4.05835176777658 bayes_pls_golite062009
endodeoxyribonuclease activity 4.04079853250282 bayes_pls_golite062009
transferase activity 3.80228208941612 bayes_pls_golite062009
deoxyribonuclease activity 2.53877834217178 bayes_pls_golite062009
RNA polymerase activity 1.98947494839394 bayes_pls_golite062009
DNA-directed RNA polymerase activity 1.98947494839394 bayes_pls_golite062009
ribonuclease activity 1.65398017104387 bayes_pls_golite062009
binding 1.65023283997779 bayes_pls_golite062009
nucleic acid binding 1.58132518850155 bayes_pls_golite062009
DNA binding 1.49092185389589 bayes_pls_golite062009
exonuclease activity 1.38951646742998 bayes_pls_golite062009
catalytic activity 0.985794797454925 bayes_pls_golite062009
damaged DNA binding 0.903519456111979 bayes_pls_golite062009
transcription regulator activity 0.883308266169681 bayes_pls_golite062009
structure-specific DNA binding 0.431057665208185 bayes_pls_golite062009
exoribonuclease activity 0.430099678408149 bayes_pls_golite062009
3'-5' exonuclease activity 0.427833022898625 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.35941349369351 bayes_pls_golite062009
DNA helicase activity 0.280008381637593 bayes_pls_golite062009
protein binding 0.267061490746095 bayes_pls_golite062009
single-stranded DNA binding 0.170862363182338 bayes_pls_golite062009
chromatin binding 0.154937729400031 bayes_pls_golite062009
nuclease activity 0.126991239633667 bayes_pls_golite062009
transcription factor activity 0.104696021012086 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.0394470752191727 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 0.024241485627603 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [2097-2271]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VVLETMFTNR AGFFFEWVMR KSLLKYIKVK ECAAEAEFLD PGPSFILPNV ACSNCDAYRD  60
   61 LDICRDPALL TEKEWSCADT QCGKIYDREQ MESSLLEMVR QRERMYHMQD VVCIRCNQVK 120
  121 AAHLTEQCEC SGSFRCKESG SEFSKRMEIF MDIAKRQKFR LLEEYISWII YGPSY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle