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View Structure Prediction Details

Protein: PABP3_ARATH
Organism: Arabidopsis thaliana
Length: 660 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PABP3_ARATH.

Description E-value Query
Range
Subject
Range
gi|9930616 - gi|9930616|gb|AAG02117.1|AF293840_1 poly(A) binding protein [Arabidopsis thaliana]
535.0 [0..1] [660..1]

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Predicted Domain #1
Region A:
Residues: [1-223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAVATGVA PATMVDQVPS PTAQTSVQVP VSIPLPSPVV VADQTHPNSS LYAGDLDPKV  60
   61 TEAHLFDLFK HVANVVSVRV CRDQNRRSLG YAYINFSNPN DAYRAMEALN YTPLFDRPIR 120
  121 IMLSNRDPST RLSGKGNIFI KNLDASIDNK ALFETFSSFG TILSCKVAMD VTGRSKGYGF 180
  181 VQFEKEESAQ AAIDKLNGML MNDKQVFVGH FIRRQERARD ENT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.221849
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.60920363363072 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
poly-pyrimidine tract binding 1.36691748240059 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
transcription repressor activity 1.06887262556449 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 0.597542453741953 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
structural molecule activity 0.352069985295889 bayes_pls_golite062009
hydrolase activity 0.153089401492248 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [224-316]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTPRFTNVYV KNLPKEIGED ELRKTFGKFG VISSAVVMRD QSGNSRCFGF VNFECTEAAA  60
   61 SAVEKMNGIS LGDDVLYVGR AQKKSEREEE LRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 1wf0A
Description: Solution structure of RRM domain in TAR DNA-binding protein-43
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.60920363363072 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
poly-pyrimidine tract binding 1.36691748240059 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
transcription repressor activity 1.06887262556449 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 0.597542453741953 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
structural molecule activity 0.352069985295889 bayes_pls_golite062009
hydrolase activity 0.153089401492248 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [317-415]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFEQERINRF EKSQGANLYL KNLDDSVDDE KLKEMFSEYG NVTSSKVMLN PQGMSRGFGF  60
   61 VAYSNPEEAL RALSEMNGKM IGRKPLYIAL AQRKEDRRA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.46
Match: 2f3jA
Description: No description for 2f3jA was found.

Predicted Domain #4
Region A:
Residues: [416-524]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLQALFSQIR APGPMSGFHH PPGGPMPGPP QHMYVGQNGA SMVPSQPIGY GFQPQFMPGM  60
   61 RPGSGPGNFI VPYPLQRQPQ TGPRMGFRRG ATNVQQHIQQ QQLMHRNPS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [525-660]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGMRYMNGAS NGRNGMDSSV PQGILPPIIP LPIDASSISH QKAPLLPISK LTSSLASASP  60
   61 ADRTRMLGEQ LYPLVERHEP LHVAKVTGML LEMDQAEILH LMESPEALKS KVSEALDVLR 120
  121 LSVDPTDHDL GFSTTD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.39794
Match: 1g9lA
Description: poly(A) binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
eukaryotic initiation factor 4G binding 5.42285329968544 bayes_pls_golite062009
RNA binding 4.11788426448287 bayes_pls_golite062009
mRNA binding 4.06818972936809 bayes_pls_golite062009
nucleic acid binding 3.78909647605682 bayes_pls_golite062009
single-stranded RNA binding 3.03728178586535 bayes_pls_golite062009
binding 2.76167454154417 bayes_pls_golite062009
poly(A) RNA binding 2.66269581586161 bayes_pls_golite062009
poly-purine tract binding 2.20136693536924 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.71649379151573 bayes_pls_golite062009
protein binding 0.856075580719879 bayes_pls_golite062009
acid-amino acid ligase activity 0.773419219495254 bayes_pls_golite062009
small conjugating protein ligase activity 0.4868428387769 bayes_pls_golite062009
ligase activity 0.38737123012383 bayes_pls_golite062009
catalytic activity 0.287695754348243 bayes_pls_golite062009
translation initiation factor binding 0.06484451210501 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle