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View Structure Prediction Details

Protein: PABP3_ARATH
Organism: Arabidopsis thaliana
Length: 660 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PABP3_ARATH.

Description E-value Query
Range
Subject
Range
gi|9930616 - gi|9930616|gb|AAG02117.1|AF293840_1 poly(A) binding protein [Arabidopsis thaliana]
535.0 [0..1] [660..1]

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Predicted Domain #1
Region A:
Residues: [1-223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAVATGVA PATMVDQVPS PTAQTSVQVP VSIPLPSPVV VADQTHPNSS LYAGDLDPKV  60
   61 TEAHLFDLFK HVANVVSVRV CRDQNRRSLG YAYINFSNPN DAYRAMEALN YTPLFDRPIR 120
  121 IMLSNRDPST RLSGKGNIFI KNLDASIDNK ALFETFSSFG TILSCKVAMD VTGRSKGYGF 180
  181 VQFEKEESAQ AAIDKLNGML MNDKQVFVGH FIRRQERARD ENT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.221849
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.60920363363072 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
poly-pyrimidine tract binding 1.36691748240059 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
transcription repressor activity 1.06887262556449 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 0.597542453741953 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
structural molecule activity 0.352069985295889 bayes_pls_golite062009
hydrolase activity 0.153089401492248 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [224-316]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTPRFTNVYV KNLPKEIGED ELRKTFGKFG VISSAVVMRD QSGNSRCFGF VNFECTEAAA  60
   61 SAVEKMNGIS LGDDVLYVGR AQKKSEREEE LRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 1wf0A
Description: Solution structure of RRM domain in TAR DNA-binding protein-43
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.60920363363072 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
poly-pyrimidine tract binding 1.36691748240059 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
transcription repressor activity 1.06887262556449 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 0.597542453741953 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
structural molecule activity 0.352069985295889 bayes_pls_golite062009
hydrolase activity 0.153089401492248 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [317-415]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFEQERINRF EKSQGANLYL KNLDDSVDDE KLKEMFSEYG NVTSSKVMLN PQGMSRGFGF  60
   61 VAYSNPEEAL RALSEMNGKM IGRKPLYIAL AQRKEDRRA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.46
Match: 2f3jA
Description: No description for 2f3jA was found.

Predicted Domain #4
Region A:
Residues: [416-524]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLQALFSQIR APGPMSGFHH PPGGPMPGPP QHMYVGQNGA SMVPSQPIGY GFQPQFMPGM  60
   61 RPGSGPGNFI VPYPLQRQPQ TGPRMGFRRG ATNVQQHIQQ QQLMHRNPS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [525-660]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGMRYMNGAS NGRNGMDSSV PQGILPPIIP LPIDASSISH QKAPLLPISK LTSSLASASP  60
   61 ADRTRMLGEQ LYPLVERHEP LHVAKVTGML LEMDQAEILH LMESPEALKS KVSEALDVLR 120
  121 LSVDPTDHDL GFSTTD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.39794
Match: 1g9lA
Description: poly(A) binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
eukaryotic initiation factor 4G binding 5.42285329968544 bayes_pls_golite062009
RNA binding 4.11788426448287 bayes_pls_golite062009
mRNA binding 4.06818972936809 bayes_pls_golite062009
nucleic acid binding 3.78909647605682 bayes_pls_golite062009
single-stranded RNA binding 3.03728178586535 bayes_pls_golite062009
binding 2.76167454154417 bayes_pls_golite062009
poly(A) RNA binding 2.66269581586161 bayes_pls_golite062009
poly-purine tract binding 2.20136693536924 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.71649379151573 bayes_pls_golite062009
protein binding 0.856075580719879 bayes_pls_golite062009
acid-amino acid ligase activity 0.773419219495254 bayes_pls_golite062009
small conjugating protein ligase activity 0.4868428387769 bayes_pls_golite062009
ligase activity 0.38737123012383 bayes_pls_golite062009
catalytic activity 0.287695754348243 bayes_pls_golite062009
translation initiation factor binding 0.06484451210501 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle