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View Structure Prediction Details

Protein: pdk-1
Organism: Caenorhabditis elegans
Length: 636 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pdk-1.

Description E-value Query
Range		 Subject
Range
pdk-1 - protein kinase status:Confirmed UniProt:Q9Y1J3 protein_id:AAK82904.1
 435.0 [0..1] [636..1]

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Predicted Domain #1
Region A:
Residues: [1-380] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDLTPTNTS LDTTTTNNDT TSDREAAPTT LNLTPTASES ENSLSPVTAE DLIAKSIKEG  60
   61 CPKRTSNDFM FLQSMGEGAY SQVFRCREVA TDAMFAVKVL QKSYLNRHQK MDAIIREKNI 120
  121 LTYLSQECGG HPFVTQLYTH FHDQARIYFV IGLVENGDLG ESLCHFGSFD MLTSKFFASE 180
  181 ILTGLQFLHD NKIVHRDMKP DNVLIQKDGH ILITDFGSAQ AFGGLQLSQE GFTDANQASS 240
  241 RSSDSGSPPP TRFYSDEEVP EENTARRTTF VGTALYVSPE MLADGDVGPQ TDIWGLGCIL 300
  301 FQCLAGQPPF RAVNQYHLLK RIQELDFSFP EGFPEEASEI IAKILVRDPS TRITSQELMA 360
  361 HKFFENVDWV NIANIKPPVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 66.09691
Match: 1okyA
Description: Structure of human PDK1 kinase domain in complex with staurosporine
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 4.31938467136214 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
acetylcholine receptor activator activity 1.83545227594542 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.82515074380651 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
telethonin binding 1.04264263421201 bayes_pls_golite062009
ErbB-2 class receptor binding 1.02996109010965 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.99838484913572 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
growth factor binding 0.86076618871384 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
alpha-actinin binding 0.181804774839734 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
collagen binding 0.126438719981406 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [381-559] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HAYIPATFGE PEYYSNIGPV EPGLDDRALF RLMNLGNDAS ASQPSTFRPS NVEHRGDPFV  60
   61 SEIAPRANSE AEKNRAARAQ KLEEQRVKNP FHIFTNNSLI LKQGYLEKKR GLFARRRMFL 120
  121 LTEGPHLLYI DVPNLVLKGE VPWTPCMQVE LKNSGTFFIH TPNRVYYLFD LEKKADEWC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.30103
Match: 1w1dA
Description: Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to Inositol (1,3,4,5)-tetrakisphosphate
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 3.72754591832642 bayes_pls_golite062009
cytoskeletal protein binding 3.48744511411671 bayes_pls_golite062009
binding 3.29080729281876 bayes_pls_golite062009
protein binding 3.17213698546013 bayes_pls_golite062009
insulin receptor binding 2.87341016128079 bayes_pls_golite062009
transcription regulator activity 2.10584700564436 bayes_pls_golite062009
actin filament binding 2.03444575838575 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.87491821448967 bayes_pls_golite062009
nucleic acid binding 1.85794418941003 bayes_pls_golite062009
DNA binding 1.77960272183811 bayes_pls_golite062009
GTPase regulator activity 1.66986263418539 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.64990514605397 bayes_pls_golite062009
molecular transducer activity 1.55319485371003 bayes_pls_golite062009
signal transducer activity 1.55319485371003 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.53043443218632 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.51433521241924 bayes_pls_golite062009
kinase activity 1.49733072352288 bayes_pls_golite062009
SH2 domain binding 1.41526564231882 bayes_pls_golite062009
cell adhesion molecule binding 1.3855488465667 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.36365892826676 bayes_pls_golite062009
protein kinase activity 1.34246406302496 bayes_pls_golite062009
transporter activity 1.28986800087234 bayes_pls_golite062009
small GTPase regulator activity 1.2550809703725 bayes_pls_golite062009
enzyme regulator activity 1.25381967078645 bayes_pls_golite062009
insulin-like growth factor receptor binding 1.19081327922916 bayes_pls_golite062009
receptor activity 1.1755016270537 bayes_pls_golite062009
enzyme binding 1.17212675145623 bayes_pls_golite062009
transmembrane receptor activity 1.1152029796159 bayes_pls_golite062009
phospholipid binding 1.09683218092034 bayes_pls_golite062009
Ran GTPase binding 1.07023555877478 bayes_pls_golite062009
transferase activity 1.05502123133116 bayes_pls_golite062009
receptor binding 1.00859318603128 bayes_pls_golite062009
receptor signaling protein activity 1.00400540041137 bayes_pls_golite062009
oxidoreductase activity 0.965872107791437 bayes_pls_golite062009
kinase binding 0.961706066143 bayes_pls_golite062009
protein domain specific binding 0.90578029954417 bayes_pls_golite062009
small GTPase binding 0.8507658747425 bayes_pls_golite062009
GTPase binding 0.82889812790119 bayes_pls_golite062009
substrate-specific transporter activity 0.79883446648737 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.745321902095093 bayes_pls_golite062009
phosphoinositide binding 0.71817045430443 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.704949129344961 bayes_pls_golite062009
protein kinase binding 0.67284191028382 bayes_pls_golite062009
protein serine/threonine kinase activity 0.611829373978789 bayes_pls_golite062009
protein complex binding 0.55916857709427 bayes_pls_golite062009
histone binding 0.359498460253937 bayes_pls_golite062009
structural constituent of cytoskeleton 0.35466574267734 bayes_pls_golite062009
structural molecule activity 0.320527491838187 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity 0.28468123649303 bayes_pls_golite062009
profilin binding 0.21255426011209 bayes_pls_golite062009
G-protein-coupled receptor binding 0.12466518799375 bayes_pls_golite062009
pyrophosphatase activity 0.0611639610381174 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0524559849408587 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0498422520006935 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [560-636] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAINDVRKRY SVTIEKTFNS AMRDGTFGSI YGKKKSRKEM MREQKALRRK QEKEEKKALK  60
   61 AEQVSKKLSM QMDKKSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle